补肾益心片联合西药治疗高血压的Meta分析和系统评价
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摘要
目的对补肾益心片联合西药治疗高血压的临床疗效进行Meta分析和系统评价,为补肾益心片联合西药治疗高血压提供循证依据,以为临床治疗高血压的方案提供参考依据。方法收集已公开发表的有关补肾益心片联合西药对高血压的临床疗效的随机对照试验(RCT),按Meta分析的要求对检索到的原始研究进行质量评估,采用RevMan5.3对符合条件的研究进行Meta分析,评价补肾益心片联合对高血压的临床疗效。结果符合纳入标准文献共9篇,总样本量691例。补肾益心片联合西药和单纯西药对收缩压降压疗效比较差异有统计学意义[SMD=-0.31,95%CI(-0.46,-0.15),Z=3.98,P<0.000 1];对舒张压降压疗效比较差异有统计学意义[SMD=-0.18,95%CI(-0.33,-0.03),Z=2.32,P=0.02]。结论补肾益心片联合西药治疗高血压与单纯西药相比较,疗效显著,具有一定的优势。
Objective To evaluate the efficacy of Bushen Yixin tablets(BYT)with western medicine for the treatment of hypertension.Methods The randomized controlled trials(RCTs)for the clinical efficacy of BYT and western medicine for hypertension were collected.The quality of the retrieved original study was evaluated according to the meta-analysis requirements.Meta-analysis of eligible studies was performed using RevMan 5.3.The clinical efficacy of BYT and western medicine for hypertension was evaluated.Results Totally 9 studies including 691 cases were analyzed.Compared with western medicine,BYT and western medicine had lower systolic pressure[SMD=-0.31,95% CI(-0.46,-0.15),Z=3.98,P<0.000 1],and lower diastolic blood pressure[SMD=-0.18,95% CI(-0.33,-0.03),Z=2.32,P=0.02].Conclusion The clinical efficacy of BYT and western medicine for hypertension is better than that of western medicine.
Objective To evaluate the efficacy of Bushen Yixin tablets(BYT)with western medicine for the treatment of hypertension.Methods The randomized controlled trials(RCTs)for the clinical efficacy of BYT and western medicine for hypertension were collected.The quality of the retrieved original study was evaluated according to the meta-analysis requirements.Meta-analysis of eligible studies was performed using RevMan 5.3.The clinical efficacy of BYT and western medicine for hypertension was evaluated.Results Totally 9 studies including 691 cases were analyzed.Compared with western medicine,BYT and western medicine had lower systolic pressure[SMD=-0.31,95% CI(-0.46,-0.15),Z=3.98,P<0.000 1],and lower diastolic blood pressure[SMD=-0.18,95% CI(-0.33,-0.03),Z=2.32,P=0.02].Conclusion The clinical efficacy of BYT and western medicine for hypertension is better than that of western medicine.
引文
[1]刘力生.中国高血压防治指南2010[J].中华高血压杂志,2011(8):701.
[2]孙益群.补肾益心片有效部位筛查[J].今日药学,2012,22(11):645-648.
[3]卿立金.补肾益心片对高血压伴勃起功能障碍患者及其血管内皮功能影响的临床观察[J].上海中医药杂志,2016,50(12):41-43.
[4]古强华.补肾法治疗肾虚型高血压患者中医症候及生活质量的临床观察[D].广州:广州中医药大学,2016:1-32.
[5]吴伟.补肾益心片对高血压病患者生活质量的影响[J].新中医,2002,34(8):32-33.
[6]杨德军.补肾益心片对原发性高血压患者的治疗作用及其机制研究[D].广州:广州中医药大学,2012:1-42.
[7]梁可晖.淫羊藿配伍车前子治疗原发性高血压早期肾损害的疗效观察[D].广州:广州中医药大学,2015:1-34.
[8]王芸素.补肾益心片改善高血压患者胰岛素抵抗的临床研究[D].广州:广州中医药大学,2002:1-45.
[9]罗朝湖.淫羊藿配伍车前子治疗H型高血压病的临床观察[D].广州:广州中医药大学,2014:1-41.
[10]郭立恒.补肾益心片改善高血压病人生活质量的临床和实验研究[D].广州:广州中医药大学,2000:1-63.
[11]黄火剑.补肾益心片对原发性高血压患者的治疗作用及其机制研究[D].广州:广州中医药大学,2011:1-43.
[12]丁爱国.肾虚血瘀与高血压病[J].实用中西医结合杂志,1995,11(4):211-212.
[13]方企扬.补肾活血方治疗高血压病80例[J].江苏中医,1998,19(11):22-23.
[14]上海国家中医药管理局《中华本草》编委会.中华本草(精选)[M].上海:上海科学技术出版社,1998:1787-1789.
[2]孙益群.补肾益心片有效部位筛查[J].今日药学,2012,22(11):645-648.
[3]卿立金.补肾益心片对高血压伴勃起功能障碍患者及其血管内皮功能影响的临床观察[J].上海中医药杂志,2016,50(12):41-43.
[4]古强华.补肾法治疗肾虚型高血压患者中医症候及生活质量的临床观察[D].广州:广州中医药大学,2016:1-32.
[5]吴伟.补肾益心片对高血压病患者生活质量的影响[J].新中医,2002,34(8):32-33.
[6]杨德军.补肾益心片对原发性高血压患者的治疗作用及其机制研究[D].广州:广州中医药大学,2012:1-42.
[7]梁可晖.淫羊藿配伍车前子治疗原发性高血压早期肾损害的疗效观察[D].广州:广州中医药大学,2015:1-34.
[8]王芸素.补肾益心片改善高血压患者胰岛素抵抗的临床研究[D].广州:广州中医药大学,2002:1-45.
[9]罗朝湖.淫羊藿配伍车前子治疗H型高血压病的临床观察[D].广州:广州中医药大学,2014:1-41.
[10]郭立恒.补肾益心片改善高血压病人生活质量的临床和实验研究[D].广州:广州中医药大学,2000:1-63.
[11]黄火剑.补肾益心片对原发性高血压患者的治疗作用及其机制研究[D].广州:广州中医药大学,2011:1-43.
[12]丁爱国.肾虚血瘀与高血压病[J].实用中西医结合杂志,1995,11(4):211-212.
[13]方企扬.补肾活血方治疗高血压病80例[J].江苏中医,1998,19(11):22-23.
[14]上海国家中医药管理局《中华本草》编委会.中华本草(精选)[M].上海:上海科学技术出版社,1998:1787-1789.