氨基末端B型脑钠肽前体和肌钙蛋白Ⅰ联合检测对慢性心力衰竭患者的诊断意义
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摘要
目的探讨联合检测NT-proBNP和cTnⅠ对慢性心力衰竭(CHF)患者的诊断意义。方法以本院2017年6月至2018年9月收治的79例CHF患者作为实验组,同期79例健康体检者作为对照组,比较两组的NT-proBNP和cTnⅠ水平,比较NT-proBNP、 cTnⅠ单独与联合检测的阳性率。结果实验组的血清NT-proBNP和cTnⅠ水平均显著高于对照组(P <0.05)。实验组中, NYHAⅡ级患者的血清NT-proBNP和cTnⅠ水平显著低于NYHAⅢ级患者, NYHAⅢ级患者的血清NT-proBNP和cTnⅠ水平显著低于NYHAⅣ级患者(P <0.05)。NT-proBNP、 cTnⅠ单独检测的阳性率均低于联合检测的阳性率(P <0.05)。结论 NT-proBNP和cTnⅠ均与心功能相关, NT-proBNP和cTnⅠ联合检测对于CHF患者具有较好的诊断效果。
Objective To explore the significance of combined detection of NT-proBNP and cTnⅠ in the diagnosis of patients with chronic heart failure(CHF). Methods From June 2017 to September 2018, 79 cases of CHF patients in our hospital were set as the experimental group, and 79 cases of healthy subjects were selected as the control group. The levels of NT-proBNP and cTnⅠ were compared between two groups, and the positive rates of single detection of NT-proBNP, single detection of cTn Ⅰ, and combined detection of NT-proBNP and cTnⅠ were compared. Results The levels of serum NT-proBNP and cTnⅠ of the experimental group were significantly higher than those of the control group(P <0.05). Among patients in the experimental group, the levels of serum NT-proBNP and cTn Ⅰ of NYHAⅡ degree were significantly lower than those of NYHAⅢ degree, and the serum NT-proBNP and cTnⅠ of NYHAⅢ degree were significantly lower than those of NYHA Ⅳ degree(P <0.05). The positive rate of combined detection of NT-proBNP and cTn Ⅰ was significantly higher than that of single detection of NT-proBNP and single detection of cTnⅠ(P <0.05). Conclusions NT-proBNP and cTnⅠare both related to cardiac function. The combined detection of NT-proBNP and cTnI has a good diagnostic effect on CHF patients.
Objective To explore the significance of combined detection of NT-proBNP and cTnⅠ in the diagnosis of patients with chronic heart failure(CHF). Methods From June 2017 to September 2018, 79 cases of CHF patients in our hospital were set as the experimental group, and 79 cases of healthy subjects were selected as the control group. The levels of NT-proBNP and cTnⅠ were compared between two groups, and the positive rates of single detection of NT-proBNP, single detection of cTn Ⅰ, and combined detection of NT-proBNP and cTnⅠ were compared. Results The levels of serum NT-proBNP and cTnⅠ of the experimental group were significantly higher than those of the control group(P <0.05). Among patients in the experimental group, the levels of serum NT-proBNP and cTn Ⅰ of NYHAⅡ degree were significantly lower than those of NYHAⅢ degree, and the serum NT-proBNP and cTnⅠ of NYHAⅢ degree were significantly lower than those of NYHA Ⅳ degree(P <0.05). The positive rate of combined detection of NT-proBNP and cTn Ⅰ was significantly higher than that of single detection of NT-proBNP and single detection of cTnⅠ(P <0.05). Conclusions NT-proBNP and cTnⅠare both related to cardiac function. The combined detection of NT-proBNP and cTnI has a good diagnostic effect on CHF patients.
引文
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[10]史金伟,岳天霞.慢性心衰患者C-反应蛋白、心肌肌钙蛋白I及糖类抗原CA125的检测结果[J].实用检验医师杂志,2016,8(4):212-214.
[11]薛婉婉.B型脑钠肽在慢性心力衰竭临床诊断、心功能评价及危险分层中的价值[J].临床合理用药杂志,2018,11(3A):125-126.
[12]董艳丽.慢性心力衰竭患者血清学指标的表达及与NYHA分级的相关性分析[J].重庆医学,2018,47(33):4307-4309.
[2]罗威.N末端脑钠肽前体、肌酸激酶同工酶、心肌肌钙蛋白I在老年慢性心力衰竭患者中的检测及意义[J].医疗装备,2018,31(17):76-77.
[3]Ponikowski P,Voors AA,Anker SD,et al.2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure[J].Rev Esp Cardiol(Engl Ed),2016,69(12):1167.
[4]徐亮,杨松,王稳,等.NT-proBNP对慢性心力衰竭患者心功能的评估价值[J].临床和实验医学杂志,2018,17(24):2626-2629.
[5]刘澍昕,李尚林,秦俭,等.脑钠肽在老年心力衰竭诊断及预后评估价值[J].当代医学,2018,24(14):33-35.
[6]刘洪莉,赵玉芬.N末端脑钠肽、心肌肌钙蛋白I与胱抑素C联合检测在慢性心力衰竭患者中的应用[J].实验与检验医学,2017,35(3):425-426,433.
[7]吴辉.慢性心力衰竭患者肌钙蛋白I水平与心功能分级的关系[J].内蒙古医学杂志,2013,45(11):1284-1286.
[8]高枫,韩肖肖,毕云,等.慢性心衰患者血清NT-proBNP和cTnⅠ联合检测及临床意义[J].陕西医学杂志,2017,46(3):325-327.
[9]亢扬,富路.心力衰竭患者血浆B型利钠肽/氨基末端利钠肽原水平正常的研究进展[J].心血管病学进展,2018,39(4):622-624.
[10]史金伟,岳天霞.慢性心衰患者C-反应蛋白、心肌肌钙蛋白I及糖类抗原CA125的检测结果[J].实用检验医师杂志,2016,8(4):212-214.
[11]薛婉婉.B型脑钠肽在慢性心力衰竭临床诊断、心功能评价及危险分层中的价值[J].临床合理用药杂志,2018,11(3A):125-126.
[12]董艳丽.慢性心力衰竭患者血清学指标的表达及与NYHA分级的相关性分析[J].重庆医学,2018,47(33):4307-4309.