肝肾阴虚型高血压采用杞菊地黄丸与硝苯地平缓释片联合治疗临床疗效观察
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摘要
目的 :探讨肝肾阴虚型高血压采用杞菊地黄丸与硝苯地平缓释片联合治疗的临床疗效。方法 :选择2016年7月—2017年2月在大连市中医医院心内科病房诊断的肝肾阴虚型高血压患者60例为研究对象,随机分为研究组与对照组各30例。对照组采用硝苯地平缓释片治疗,研究组在此基础上加用杞菊地黄丸治疗,比较两组治疗后收缩压、舒张压水平以及临床疗效。结果 :研究组治疗后收缩压(125.2±6.0)mmHg,舒张压(80.3±2.6)mmHg;对照组治疗后收缩压(133.4±5.8)mmHg,舒张压(88.1±3.5)mmHg。治疗后,两组收缩压与舒张压均显著低于治疗前,差异有统计学意义(P<0.05);治疗后,研究组收缩压与舒张压显著低于对照组,差异有统计学意义(P<0.05)。研究组总有效率96.7%,显著高于对照组的73.3%,差异有统计学意义(P<0.05)。结论 :肝肾阴虚型高血压患者采用杞菊地黄丸与硝苯地平缓释片联合治疗能够显著提高临床疗效,有效降低收缩压与舒张压。
Objective :To investigate the clinical effect of Qiju Dihuang Pill combined with sustainedrelease nifedipine on hypertension of liver-kidney Yin deficiency type. Methods :60 cases of hypertensive patients with liver-kidney Yin deficiency type,which diagnosed in department of cardiology of Dalian hospital of traditional Chinese medicine from July 2016 to February 2017 were randomly divided into study group and control group,30 cases in each group. The control group was treated with sustainedrelease nifedipine,and the study group was treated with Qiju Dihuang Pill. The systolic blood pressure,diastolic blood pressure and clinical efficacy of the two groups were compared. Results :The study group received post-treatment systolic blood pressure was(125.2±6.0)mmHg,diastolic blood pressure was(80.3±2.6)mmHg;control group systolic blood pressure was(133.4±5.8) mmHg,diastolic blood pressure was(88.1±3.5)mmHg. After treatment,the systolic and diastolic blood pressures of the two groups were significantly lower than those before treatment(P<0.05). After treatment,the systolic and diastolic blood pressure of the study group was significantly lower than that of the control group,and the difference was statistically significant(P<0.05). The total effective rate of the study group was 96.7%,which was significantly higher than that of the control group(73.3%). The difference was statistically significant(P<0.05). Conclusion :The combination of Qiju Dihuang Pill and sustained-release nifedipine can significantly improve the clinical efficacy and effectively reduce systolic and diastolic blood pressure on liver-kidney Yin deficiency type hypertensive patients.
Objective :To investigate the clinical effect of Qiju Dihuang Pill combined with sustainedrelease nifedipine on hypertension of liver-kidney Yin deficiency type. Methods :60 cases of hypertensive patients with liver-kidney Yin deficiency type,which diagnosed in department of cardiology of Dalian hospital of traditional Chinese medicine from July 2016 to February 2017 were randomly divided into study group and control group,30 cases in each group. The control group was treated with sustainedrelease nifedipine,and the study group was treated with Qiju Dihuang Pill. The systolic blood pressure,diastolic blood pressure and clinical efficacy of the two groups were compared. Results :The study group received post-treatment systolic blood pressure was(125.2±6.0)mmHg,diastolic blood pressure was(80.3±2.6)mmHg;control group systolic blood pressure was(133.4±5.8) mmHg,diastolic blood pressure was(88.1±3.5)mmHg. After treatment,the systolic and diastolic blood pressures of the two groups were significantly lower than those before treatment(P<0.05). After treatment,the systolic and diastolic blood pressure of the study group was significantly lower than that of the control group,and the difference was statistically significant(P<0.05). The total effective rate of the study group was 96.7%,which was significantly higher than that of the control group(73.3%). The difference was statistically significant(P<0.05). Conclusion :The combination of Qiju Dihuang Pill and sustained-release nifedipine can significantly improve the clinical efficacy and effectively reduce systolic and diastolic blood pressure on liver-kidney Yin deficiency type hypertensive patients.
引文
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[18]黄月芳,楼招欢,陈坚翱.天麻钩藤饮对肝阳上亢证急性脑梗死患者同型半胱氨酸的影响及临床疗效观察[J].中华中医药学刊,2014,32(2):352-354.
[19]黄再峰,陈梅芳,成坚.天麻钩藤饮联合厄贝沙坦治疗肝阳上亢型高血压的效果分析[J].中医临床研究,2018,10(17):25-27.
[20]付晓乐.天麻钩藤饮联合硝苯地平治疗高血压(肝阳上亢)随机平行对照研究[J].实用中医内科杂志,2018,32(5):40-42.
[21]曾艳红.六味地黄丸的药理分析及临床应用[J].基层医学论坛,2017,21(26):3579-3580.
[22]王桃梅,赵俊香,陈琨,等.枸杞蛋白酶解液对ACE活性的抑制作用及其对高血压大鼠的降压效果研究[J].宁夏医科大学学报,2018,40(1):11-16.
[23]孙锦贤,余静珠.珍菊降压片早、中二次投药的降压效果[J].临床合理用药杂志,2009,2(14):5-7.
[2]梁君昭,董秋芬,苏建,等.高血压病中医证素分布研究[J].河南中医,2018,38(2):241-243.
[3]苏庆侦.杞菊地黄丸治疗老年单纯收缩期高血压疗效观察[J].临床合理用药杂志,2018,11(13):17-18.
[4]中国高血压防治指南修订委员会.中国高血压防治指南2010[J].中华心血管病杂志,2011,39(7):579-616.
[5]郑筱萸.中药新药治疗高血压病的临床研究指导原则(摘编之一)[J].中医药临床杂志,2007(2):118-119.
[6]张颖捷,杜万红.高血压治疗新进展[J].中国老年学杂志,2015,35(14):4084-4087.
[7]葛均波,徐永健,王辰.内科学[M].北京:人民卫生出版社,2018:248-249.
[8]张继烈,鞠鲤亦.补脾益气法治疗高血压[J].内蒙古中医药,2012,31(5):39-40.
[9]高启秀,邓乃哲,刘锦,等.五积散合四逆汤治疗高血压病验案分析[J].中国中医急症,2012,21(11):1789-1805.
[10]宁培云,赵洪勇,赵志超,等.丹红注射液对实验性脑出血大鼠脑水肿及血浆MMP-9、TIMP-1、NF-κB水平的影响[J].疑难病杂志,2017,16(8):821-824.
[11]蓝琳友,洪溪屏,蔡元晖.NF-κB和AQP-4在亚低温治疗大鼠脑出血中的作用[J].医学研究杂志,2014,43(8):114-117.
[12]王恒,邵恩得,张金荣.高血压性大鼠脑出血后核因子-κB表达的变化[J].实用临床医药杂志,2013,17(7):5-7,19.
[13]张静轩,邵恩得,田世文.高血压性大鼠脑出血血肿量对NF-κB表达的影响[J].河北医药,2009,31(14):1732-1734.
[14]王家艳,康宁,黄宏敏.中医药治疗出血性中风急性期研究现状[J].海南医学,2015,26(4):550-554.
[15]彭伟献,陈远园.从脑出血的病理变化过程探讨活血化瘀法在出血性中风中的应用[J].中华全科医学,2015,13(5):831-833,844.
[16]周燕,李正欢,廖慧玲.天麻钩藤饮加风药治疗高血压(肝阳上亢证)大鼠风药增效性研究[J].亚太传统医药,2018,14(3):26-29.
[17]张帆.天麻钩藤饮在肝阳上亢型高血压治疗中的应用[J].河北北方学院学报(自然科学版),2017,33(12):37-38.
[18]黄月芳,楼招欢,陈坚翱.天麻钩藤饮对肝阳上亢证急性脑梗死患者同型半胱氨酸的影响及临床疗效观察[J].中华中医药学刊,2014,32(2):352-354.
[19]黄再峰,陈梅芳,成坚.天麻钩藤饮联合厄贝沙坦治疗肝阳上亢型高血压的效果分析[J].中医临床研究,2018,10(17):25-27.
[20]付晓乐.天麻钩藤饮联合硝苯地平治疗高血压(肝阳上亢)随机平行对照研究[J].实用中医内科杂志,2018,32(5):40-42.
[21]曾艳红.六味地黄丸的药理分析及临床应用[J].基层医学论坛,2017,21(26):3579-3580.
[22]王桃梅,赵俊香,陈琨,等.枸杞蛋白酶解液对ACE活性的抑制作用及其对高血压大鼠的降压效果研究[J].宁夏医科大学学报,2018,40(1):11-16.
[23]孙锦贤,余静珠.珍菊降压片早、中二次投药的降压效果[J].临床合理用药杂志,2009,2(14):5-7.