血府逐瘀汤与阿托伐他汀钙联合治疗对老年高血压患者同型半胱氨酸的影响
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摘要
目的探讨血府逐瘀汤与阿托伐他汀钙联合治疗对老年高血压患者同型半胱氨酸的影响,从而减少心脑血管事件发生。方法研究对象为2009年11月~2013年11月期间我院收治的103例老年高血压患者,按照入院的先后顺序分为两组,对照组51例采用阿托伐他汀钙治疗,研究组52例采用血府逐瘀汤与阿托伐他汀钙联合治疗,比较两组有效降压率、24h SBP、24h DBP及血浆Hcy水平的变化。结果 1对照组有效降压率(72.55%)与研究组(76.92%)比较差异无统计学意义(P>0.05)。2对照组及研究组治疗后24h SBP、24h DBP均明显低于治疗前,治疗前后比较差异有统计学意义(P<0.05)。治疗后研究组24h SBP、24h DBP与对照组治疗后比较差异无统计学意义(P>0.05)。3对照组及研究组Hcy水平均低于治疗前,研究组治疗前后差异有统计学意义(P<0.05),研究组治疗后Hcy水平明显低于对照组治疗后,两组差异有统计学意义(P<0.05)。结论采用血府逐瘀汤与阿托伐他汀钙联合治疗老年高血压患者可明显降低患者的血压水平,对Hcy的降低程度显著优于单独应用阿托伐他汀钙治疗。
Objective To investigate Xuefuzhuyu soup with atorvastatin calcium combination therapy in elderly patients with hypertension, Hcy level influence,Thereby reducing cardiovascular events. Methods The subjects included 103 cases of elderly patients with hypertension,all of them were selected from November 2009 to November 2013 in our hospital, according to the order of admission were divided into two groups, the control group had 51 cases, they used atorvastatin calcium therapy, the study group had 52 cases, used Xuefuzhuyu soup with atorvastatin calcium combination therapy. Effective antihypertensive rates, 24 h SBP, 24 h DBP degree of change and plasma Hcy levels of two groups were compared. Results(1)The rate of effective blood pressure of the control group(72.55%) compared with the study group(76.92%) had no significant difference(P>0.05).(2)24h SBP, 24 h DBP of the study group and the control group after treatment were significantly lower than before treatment, after treatment and before treatment had significant difference(P<0.05). 24 h SBP, 24 h DBP of the study group after treatment compared with the control group after treatment had no significant difference(P>0.05).(3)Hcy levels of the control group and the study group after treatment were lower than before treatment, the study group before treatment and after treatment had significant difference(P<0.05), Hcy levels of the study group after treatment was significantly lower than the control group, the difference was significant(P<0.05).Conclusion Xuefuzhuyu soup with atorvastatin calcium combination therapy in elderly hypertensive patients can significantly lower the blood pressure levels in patients, reduce the degree of Hcy is significantly better than atorvastatin alone calcium therapy.
Objective To investigate Xuefuzhuyu soup with atorvastatin calcium combination therapy in elderly patients with hypertension, Hcy level influence,Thereby reducing cardiovascular events. Methods The subjects included 103 cases of elderly patients with hypertension,all of them were selected from November 2009 to November 2013 in our hospital, according to the order of admission were divided into two groups, the control group had 51 cases, they used atorvastatin calcium therapy, the study group had 52 cases, used Xuefuzhuyu soup with atorvastatin calcium combination therapy. Effective antihypertensive rates, 24 h SBP, 24 h DBP degree of change and plasma Hcy levels of two groups were compared. Results(1)The rate of effective blood pressure of the control group(72.55%) compared with the study group(76.92%) had no significant difference(P>0.05).(2)24h SBP, 24 h DBP of the study group and the control group after treatment were significantly lower than before treatment, after treatment and before treatment had significant difference(P<0.05). 24 h SBP, 24 h DBP of the study group after treatment compared with the control group after treatment had no significant difference(P>0.05).(3)Hcy levels of the control group and the study group after treatment were lower than before treatment, the study group before treatment and after treatment had significant difference(P<0.05), Hcy levels of the study group after treatment was significantly lower than the control group, the difference was significant(P<0.05).Conclusion Xuefuzhuyu soup with atorvastatin calcium combination therapy in elderly hypertensive patients can significantly lower the blood pressure levels in patients, reduce the degree of Hcy is significantly better than atorvastatin alone calcium therapy.
引文
[1]刘玉梅.血府逐瘀汤加减治疗高血压病临床观察[J].新疆中医药,2014,32(1):10-12.
[2]张绍深.阿托伐他汀钙对顽固性高血压降压疗效影响的临床分析[J].中国医学创新,2011,8(19):14-16.
[3]程艳杰,王桂荣,尹丽萍,等.苯磺酸氨氯地平联合阿托伐他汀治疗老年性高血压病疗效观察[J].中国当代医药,2010,17(5):57-58.
[4]苏华科,吴莹,甄怀蒙,等.阿托伐他汀联合硝苯地平控释片治疗老年高血压的疗效观察[J].临床和实验医学杂志,2012,11(24):1967-1968.
[5]中国高血压防治指南修订委员会,中国高血压防治指南2005年修订版[M].北京:人民卫生出版社,2006:20.
[6]刘力生.中国高血压防治指南2010[J].中华高血压杂志,2011,19(8):701-743.
[7]周勇,孟建国,张恒,等.血府逐瘀汤联合阿托伐他汀对老年高血压患者血管功能状态及心室重塑状态的影响[J].海南医学院学报,2014,20(2):198-201.
[8]薛三龙,范春雨,刘达瑾.依那普利叶酸片对高血压患者血压、血压节律及同型半胱氨酸影响研究[J].长治医学院学报,2013,27(1):32-33.
[9]张成跃.氨氯地平阿托伐他汀钙对高血压合并血脂异常患者血管功能的影响[J].中国卫生产业,2014,11(8):125,127.
[10]谭振宇,廖春燕.阿托伐他汀钙对血脂正常高血压患者的降压作用[J].心血管康复医学杂志,2014,23(1):83-85.
[11]黄淳康.中西医结合治疗原发性高血压临床研究[J].实用中医药杂志,2009,25(3):162-163.
[12]陈晓祥.血府逐瘀汤合并氨氯地平治疗血瘀型高血压的临床研究[J].中国实用医刊,2014,41(10):59-61.
[13]李芳,李霞.半夏白术天麻汤联合血府逐瘀汤佐治高血压病的疗效及对内皮功能的影响[J].广东医学,2014,35(6):936-937.
[14]江宏革.栝蒌薤白半夏汤联合血府逐瘀汤治疗心绞痛合并高脂血症临床疗效观察[J].中国医药导报,2010,7(21):81-82.
[15]黄琼坚,赵伟东.血府逐瘀汤治疗高脂血症的临床分析[J].中国当代医药,2012,19(19):140.
[16]沈元良,许莎莎.血府逐瘀汤联合酚妥拉明治疗肺心病心衰患者的疗效观察[J].中国现代医生,2014,52(21):92-95.
[2]张绍深.阿托伐他汀钙对顽固性高血压降压疗效影响的临床分析[J].中国医学创新,2011,8(19):14-16.
[3]程艳杰,王桂荣,尹丽萍,等.苯磺酸氨氯地平联合阿托伐他汀治疗老年性高血压病疗效观察[J].中国当代医药,2010,17(5):57-58.
[4]苏华科,吴莹,甄怀蒙,等.阿托伐他汀联合硝苯地平控释片治疗老年高血压的疗效观察[J].临床和实验医学杂志,2012,11(24):1967-1968.
[5]中国高血压防治指南修订委员会,中国高血压防治指南2005年修订版[M].北京:人民卫生出版社,2006:20.
[6]刘力生.中国高血压防治指南2010[J].中华高血压杂志,2011,19(8):701-743.
[7]周勇,孟建国,张恒,等.血府逐瘀汤联合阿托伐他汀对老年高血压患者血管功能状态及心室重塑状态的影响[J].海南医学院学报,2014,20(2):198-201.
[8]薛三龙,范春雨,刘达瑾.依那普利叶酸片对高血压患者血压、血压节律及同型半胱氨酸影响研究[J].长治医学院学报,2013,27(1):32-33.
[9]张成跃.氨氯地平阿托伐他汀钙对高血压合并血脂异常患者血管功能的影响[J].中国卫生产业,2014,11(8):125,127.
[10]谭振宇,廖春燕.阿托伐他汀钙对血脂正常高血压患者的降压作用[J].心血管康复医学杂志,2014,23(1):83-85.
[11]黄淳康.中西医结合治疗原发性高血压临床研究[J].实用中医药杂志,2009,25(3):162-163.
[12]陈晓祥.血府逐瘀汤合并氨氯地平治疗血瘀型高血压的临床研究[J].中国实用医刊,2014,41(10):59-61.
[13]李芳,李霞.半夏白术天麻汤联合血府逐瘀汤佐治高血压病的疗效及对内皮功能的影响[J].广东医学,2014,35(6):936-937.
[14]江宏革.栝蒌薤白半夏汤联合血府逐瘀汤治疗心绞痛合并高脂血症临床疗效观察[J].中国医药导报,2010,7(21):81-82.
[15]黄琼坚,赵伟东.血府逐瘀汤治疗高脂血症的临床分析[J].中国当代医药,2012,19(19):140.
[16]沈元良,许莎莎.血府逐瘀汤联合酚妥拉明治疗肺心病心衰患者的疗效观察[J].中国现代医生,2014,52(21):92-95.