β受体阻滞剂分别联合血管紧张素受体拮抗剂和钙离子拮抗剂治疗江门地区中青年高血压的临床效果观察
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摘要
目的:比较β受体阻滞剂分别联合血管紧张素受体拮抗剂(ARB)和钙离子拮抗剂(CCB)治疗江门地区中青年高血压的治疗效果。方法:选取2012年12月-2014年12月收治的江门地区中青年高血压患者300例,随机数字表法分为观察组和对照组各150例。观察组患者给予ARB联合β受体阻滞剂治疗,对照组给予CCB联合β受体阻滞剂治疗,观察两组治疗前后的血压、心率变化情况以及降压疗效和症状改变情况。结果:治疗8周后两组患者的血压、心率均较治疗前下降(P<0.05);观察组血压下降与对照组比较差异无统计学意义(P>0.05),观察组心率下降较对照组明显,差异有统计学意义(P<0.05)。在降压疗效方面,观察组总有效率为94.67%,高于对照组的82.00%,差异有统计学意义(P<0.05)。在症状改善方面,观察组总有效率为96.67%,高于对照组的84.67%,差异有统计学意义(P<0.05)。结论:β受体阻滞剂联合ARB能有效降低患者的舒张压和收缩压,减慢心率,且降压效果和症状改善显著,临床上值得推广使用。
Objective:To compare treatment effect of beta-blockers respectively joint angiotensin receptor blockers(ARB) and calcium channel blockers(CCB) in the treatment of middle-aged and young high blood pressure in Jiangmen.Method:300 young and middle-aged patients with high blood pressure from December 2012 to December 2014 were selected,according to random number table method was divided into observation group and control group,each for 150 patients.Observation group patients were given ARB joint beta blockers,the control group were given CCB joint beta-blockers,before and after treatment of blood pressure,heart rate,and antihypertensive effects and the changes of symptoms,change the situation of two groups were observed.Result:Two groups of patients' blood pressure,heart after 8 weeks rate down significantly compared with before treatment(P<0.05); blood pressure drop in treatment group and control group,there was no statistically significant difference(P>0.05),heart rate decline in treatment group and control group,the difference was statistically significant(P<0.05).In terms of hypertension treatment,observation group total effective rate was 94.67%,control group total effective rate was 82.00%,total effective rate of observation group was obviously higher than that of control group,the difference was statistically significant(P<0.05).In terms of symptom improvement,observation group total effective rate was 96.67%,control group total effective rate was 84.67%,total effective observation group was obviously higher than that of control group,the difference was statistically significant(P<0.05).Conclusion:The application of combined beta-blockers ARB can significantly reduce the diastolic and systolic blood pressure of patients,slow heart rate,and in terms of antihypertensive effects and symptoms improve curative effect is good,worthy of clinical promotion.
Objective:To compare treatment effect of beta-blockers respectively joint angiotensin receptor blockers(ARB) and calcium channel blockers(CCB) in the treatment of middle-aged and young high blood pressure in Jiangmen.Method:300 young and middle-aged patients with high blood pressure from December 2012 to December 2014 were selected,according to random number table method was divided into observation group and control group,each for 150 patients.Observation group patients were given ARB joint beta blockers,the control group were given CCB joint beta-blockers,before and after treatment of blood pressure,heart rate,and antihypertensive effects and the changes of symptoms,change the situation of two groups were observed.Result:Two groups of patients' blood pressure,heart after 8 weeks rate down significantly compared with before treatment(P<0.05); blood pressure drop in treatment group and control group,there was no statistically significant difference(P>0.05),heart rate decline in treatment group and control group,the difference was statistically significant(P<0.05).In terms of hypertension treatment,observation group total effective rate was 94.67%,control group total effective rate was 82.00%,total effective rate of observation group was obviously higher than that of control group,the difference was statistically significant(P<0.05).In terms of symptom improvement,observation group total effective rate was 96.67%,control group total effective rate was 84.67%,total effective observation group was obviously higher than that of control group,the difference was statistically significant(P<0.05).Conclusion:The application of combined beta-blockers ARB can significantly reduce the diastolic and systolic blood pressure of patients,slow heart rate,and in terms of antihypertensive effects and symptoms improve curative effect is good,worthy of clinical promotion.
引文
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[12]薛三龙,李娜,范春雨,等.小剂量阿罗洛尔联合左旋氨氯地平对中青年高血压的降压疗效观察[J].中国现代药物应用,2013,7(4):64-65.
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[14]杜映荣,李红娟,李杰,等.替米沙坦联合比索洛尔治疗中青年舒张期高血压的疗效观察[J].中外医学研究,2014,12(10):22-23.
[15]赵海鹰,王浩.β受体阻滞剂在中青年高血压中的应用[J].中华高血压杂志,2014,22(3):222-223.
[2]张振.抗高血压药物用药合理性调查分析[J].中国医学创新,2012,9(29):140-141.
[3]凌受毅,朱正芳,张卫国.钙拮抗剂联合β受体阻滞剂治疗中青年高血压的疗效分析[J].中西医结合心脑血管病杂志,2012,10(9):1049-1050.
[4]党爱民,刘国仗,蔡廼绳.盐酸阿罗洛尔对中青年高血压的降压疗效[J].中华高血压杂志,2011,19(2):163-166.
[5]陆再英,钟南山.内科学[M].北京:人民卫生出版社,2008:251-263.
[6]刘国仗,胡大一,陶萍,等.心血管药物临床试验评价方法的建议[J].中华心血管病杂志,1998,16(26):5-11.
[7]杨秀芹.社区中青年高血压管理体会[J].中外医学研究,2011,9(30):30-31.
[8]全国血压抽样调查协作组.中国人群高血压患病率以及变化趋势[J].高血压杂志,1995,4(增刊):7-13.
[9]赵春华,陈月华,姚成,等.部队青年高血压患病率调查及相关因素分析[J].中国心血管杂志,2001,6(2):66-68.
[10]綦瑞霞.青年人高血压影响因素分析及对策[J].中国医学创新,2012,9(5):136-137.
[11]李嵘.拜新同联合应用小剂量倍他乐克治疗青中年高血压的临床分析[J].航空航天医学杂志,2014,25(7):900-901.
[12]薛三龙,李娜,范春雨,等.小剂量阿罗洛尔联合左旋氨氯地平对中青年高血压的降压疗效观察[J].中国现代药物应用,2013,7(4):64-65.
[13]刘静.拜新同联合倍他乐克治疗中青年高血压疗效观察[J].现代中西医结合杂志,2013,22(25):2833-2834.
[14]杜映荣,李红娟,李杰,等.替米沙坦联合比索洛尔治疗中青年舒张期高血压的疗效观察[J].中外医学研究,2014,12(10):22-23.
[15]赵海鹰,王浩.β受体阻滞剂在中青年高血压中的应用[J].中华高血压杂志,2014,22(3):222-223.