H型高血压的研究进展
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摘要
H型高血压是伴有血浆同型半胱氨酸(Hcy)升高的原发性高血压,临床上较常见,高血压与高Hcy共存时可使心脑血管疾病的风险显著增加。笔者主要就H型高血压的发病机制、危害及治疗等方面进行综述。
The essential hypertension with HHCY is defined as H-hypertension. It is very common in clinic. High blood pressure and high homocysteine( HHcy) coexistence can promote a significantly increased risk of heart head blood-vessel disease. In this paper,the pathogenesis,harm and treatment of H-hypertension are summarized.
The essential hypertension with HHCY is defined as H-hypertension. It is very common in clinic. High blood pressure and high homocysteine( HHcy) coexistence can promote a significantly increased risk of heart head blood-vessel disease. In this paper,the pathogenesis,harm and treatment of H-hypertension are summarized.
引文
[1]中国高血压防治指南修订委员会.中国高血压防治指南2010年修订版[J].中国医学前言杂志电子版,2011,3(5):42,91.
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[6]吕纯芳,张涛,李丽玲.H型高血压患者代谢性相关指标及MTHFR基因多态性分析[J].中国热带医学,2014,14(1):86-88.
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[8]李红娟,刘军,郭翔宇,等.中国门诊高血压患者多重危险因素现状[J].中华心血管杂志,2011,5(39):252.
[9]侯丹丹,甄攀攀,王雯.高同型半胱氨血症与内皮祖细胞凋亡[J].生理科学进展,2011,42(2):158-160.
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[12]林小慧,刘开祥,曾爱源,等.高血压患者血浆同型半胱氨酸水平及亚甲基四氢叶酸还原酶因多态性的研究[J].实用心脑肺血管病杂志,2012,20(5):7.
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[14]Thom T,Haase N,Rosamond W,et al.Heart disease and stroke statistics2006 update:A report from the American Heart Association Statistics Committe and Stroke Statistics Subcommittee[J].Circulation,2006,113(6):85,151.
[15]Graham IM,Daly LE,Refsum HM,et al.Plasma homocysteine as a risk factor for vascular disease.The European Concerted Action Project[J].JAMA,2007,277(22):1775-1781.
[16]张岩,翟勇.双管齐下治疗H型高血压[J].中国实用内科杂志.2011.31(10):737-738.
[17]Cotlarciuc I,Andrew T,Dew T,et al.The Basis of Differential Responses to Folic Acid Supplementation[J].J Nutrigenet Nutrigenomics,2011,4:99-109.
[18]霍勇,崔一民,秦献辉,等.基于种族差异个体化的药物设计—复方马来酸依那普利叶酸片研发思路[J].临床药物治疗杂志,2014,12(1):28-32.
[19]薛三龙.依那普利叶酸片对高血压患者血压、血压节律及同型半胱氨酸影响研究[J].长治医学院学报,2013,27(1):32-33.
[20]查滨,魏忠明,郭桂玲.依那普利叶酸片治疗H型高血压疗效观察[J].航空航天医学杂志,2012,6(23):665-667.
[21]Atkinson W,Elmslie J,Lever M,et al.Dielary and supplementary helaine:acute effects on plasma betaine and tame and homocycsteine concentrations under standardand postmethionine load conditions in healthy male subject[J].Am J Clin Nutr,2008,87(3):85,577.
[22]Gao Shangchai,Xia Jiang,Zhong Feini,et al.Betaine attenuates Alzheimer like pathological changes and memory deficits induced by homocysteine.International Society for Neurochemistry[J].Neurochem,2013,124(3):388.
[23]刘振岳,张建中.痰瘀互结证对高血压患者血浆同型半胱氨酸水平的影响[J].中医药信息,2014,31(3):88-90.
[24]李卫丽,景光光,陈孝银.高同型半胱氨酸血症的中医病因病机探讨[J].辽宁中医杂志,2006,33(4):412-413.
[25]Bhandari U,Pathan RA,Kumar V.et al.Ameliorative role of atorvastatin on methionine-induced hyperhomocysteinemia and hematological changes in albino rats[J].Indian J Exp Biol.2011,49:132-139.
[26]程丝,冯娟,王宪,等.高同型半胱氨酸血症治疗研究进展[J].生理科学进展,2011,42(5):329-334.
[2]胡大一,徐希平.有效控制“H型”高血压—预防卒中的新思路[J].中华内科杂志,2008,47(12):976-977.
[3]Sen U,Mishra PK,Tyagi N,et al.Homocysteine to hydrogen sulfide or hypertension[J].Cell Biochem Biophys,2010,57(2/3):49-58.
[4]张明玺,罗俊.H型高血压的病因及发病机制[J].心血管病学进展,2012,33(2):253-256.
[5]Tomaiuolo R,Bellia C,Caruso A,et al.Prothrombotic gene variants as risk factors of acute myocardial infarction in young women[J].Translational Medicine,2012,10:235.
[6]吕纯芳,张涛,李丽玲.H型高血压患者代谢性相关指标及MTHFR基因多态性分析[J].中国热带医学,2014,14(1):86-88.
[7]Refsum H,Smith AD,Ueland PM,et al.Facts and recommendations about total homocysteine determinations:all expert opinion[J].Clin Chem,2004:50:3-32.
[8]李红娟,刘军,郭翔宇,等.中国门诊高血压患者多重危险因素现状[J].中华心血管杂志,2011,5(39):252.
[9]侯丹丹,甄攀攀,王雯.高同型半胱氨血症与内皮祖细胞凋亡[J].生理科学进展,2011,42(2):158-160.
[10]Albu E,Filip C,Zamosteanu N,et al.Hyperhomocysteinemia is an indicator of oxidant stress[J].Med Hypotheses,2012;78(4):554-555.
[11]Hamelet J,Demuth K,Paul JL,et al.Hyperhomocysteinemia due to cystathionine beta synthase deficiency induces dysregulation of genes involved in hepatic lipid homeostasis inmice[J].J Hepatol,2007,46(1):151-159.
[12]林小慧,刘开祥,曾爱源,等.高血压患者血浆同型半胱氨酸水平及亚甲基四氢叶酸还原酶因多态性的研究[J].实用心脑肺血管病杂志,2012,20(5):7.
[13]Refsum it,Nurk E,Snfith AD,et a1.The Hordaland Homocysteine Study:aeommtmity—based study of homocysteine,its determtents and associations withaisease[J].J Nutr,2006,136(6):l731-1740.
[14]Thom T,Haase N,Rosamond W,et al.Heart disease and stroke statistics2006 update:A report from the American Heart Association Statistics Committe and Stroke Statistics Subcommittee[J].Circulation,2006,113(6):85,151.
[15]Graham IM,Daly LE,Refsum HM,et al.Plasma homocysteine as a risk factor for vascular disease.The European Concerted Action Project[J].JAMA,2007,277(22):1775-1781.
[16]张岩,翟勇.双管齐下治疗H型高血压[J].中国实用内科杂志.2011.31(10):737-738.
[17]Cotlarciuc I,Andrew T,Dew T,et al.The Basis of Differential Responses to Folic Acid Supplementation[J].J Nutrigenet Nutrigenomics,2011,4:99-109.
[18]霍勇,崔一民,秦献辉,等.基于种族差异个体化的药物设计—复方马来酸依那普利叶酸片研发思路[J].临床药物治疗杂志,2014,12(1):28-32.
[19]薛三龙.依那普利叶酸片对高血压患者血压、血压节律及同型半胱氨酸影响研究[J].长治医学院学报,2013,27(1):32-33.
[20]查滨,魏忠明,郭桂玲.依那普利叶酸片治疗H型高血压疗效观察[J].航空航天医学杂志,2012,6(23):665-667.
[21]Atkinson W,Elmslie J,Lever M,et al.Dielary and supplementary helaine:acute effects on plasma betaine and tame and homocycsteine concentrations under standardand postmethionine load conditions in healthy male subject[J].Am J Clin Nutr,2008,87(3):85,577.
[22]Gao Shangchai,Xia Jiang,Zhong Feini,et al.Betaine attenuates Alzheimer like pathological changes and memory deficits induced by homocysteine.International Society for Neurochemistry[J].Neurochem,2013,124(3):388.
[23]刘振岳,张建中.痰瘀互结证对高血压患者血浆同型半胱氨酸水平的影响[J].中医药信息,2014,31(3):88-90.
[24]李卫丽,景光光,陈孝银.高同型半胱氨酸血症的中医病因病机探讨[J].辽宁中医杂志,2006,33(4):412-413.
[25]Bhandari U,Pathan RA,Kumar V.et al.Ameliorative role of atorvastatin on methionine-induced hyperhomocysteinemia and hematological changes in albino rats[J].Indian J Exp Biol.2011,49:132-139.
[26]程丝,冯娟,王宪,等.高同型半胱氨酸血症治疗研究进展[J].生理科学进展,2011,42(5):329-334.