氨氯地平联合美托洛尔治疗青年高血压病的疗效观察
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摘要
目的:探讨氨氯地平联合美托洛尔治疗青年高血压病的临床疗效。方法:选取2014年9月—2015年3月北京军区原北戴河疗养院收治的150例青年高血压病患者作为研究对象,按随机数字表法将患者分为对照1组、对照2组和观察组,每组各50例。对照1组患者单用氨氯地平治疗,对照2组患者单用美托洛尔治疗,观察组患者采用氯胺地平+美托洛尔联合治疗。观察3组患者的疗效、血压及心率变化、不良反应发生情况。结果:观察组患者治疗总有效率为96.00%(48/50),明显高于对照1组的86.00(43/50)、对照2组的84.00%(42/50),且不良反应发生率明显低于对照1组、对照2组,差异均有统计学意义(P<0.05)。结论:氨氯地平联合美托洛尔治疗青年高血压病疗效显著,副作用少,且对患者心率无不良影响,值得临床推广。
OBJECTIVE: To probe into the clinical efficacy of amlodipine combined with metoprolol in treatment of young hypertension. METHODS: 150 cases of young hypertension admitted into Beijing Military Region of Beidaihe Nursing Home from Sept. 2014 to Mar. 2015 were selected to be divided into control group one,control group two and observation group via the random number table,with 50 cases in each. The control group one were given ammonia amlodipine,the control group two were treated with metoprolol and the observation group received ammonia amlodipine combined with metoprolol. The efficacy,changes of blood pressure and heart rate and incidence of side reactions were observed in three group of patients. RESULTS: The total effective rate of observation group was 96. 00%( 48 /50),which was significantly higher than that of control group one [86. 00%( 43 /50) ] and control group two [84. 00%( 42 /50) ],the incidence of side reactions was significantly lower than that of the control group one and control group two,the difference was statistically significant( P < 0. 05). CONCLUSIONS: The efficacy of amlodipine combined with metoprolol in treatment of young hypertension is significant,with few side reactions,and has no bad effects on patients.It is worthy of promotion and application.
OBJECTIVE: To probe into the clinical efficacy of amlodipine combined with metoprolol in treatment of young hypertension. METHODS: 150 cases of young hypertension admitted into Beijing Military Region of Beidaihe Nursing Home from Sept. 2014 to Mar. 2015 were selected to be divided into control group one,control group two and observation group via the random number table,with 50 cases in each. The control group one were given ammonia amlodipine,the control group two were treated with metoprolol and the observation group received ammonia amlodipine combined with metoprolol. The efficacy,changes of blood pressure and heart rate and incidence of side reactions were observed in three group of patients. RESULTS: The total effective rate of observation group was 96. 00%( 48 /50),which was significantly higher than that of control group one [86. 00%( 43 /50) ] and control group two [84. 00%( 42 /50) ],the incidence of side reactions was significantly lower than that of the control group one and control group two,the difference was statistically significant( P < 0. 05). CONCLUSIONS: The efficacy of amlodipine combined with metoprolol in treatment of young hypertension is significant,with few side reactions,and has no bad effects on patients.It is worthy of promotion and application.
引文
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[14]郑细优,黄春平.不同剂量美托洛尔治疗原发性高血压的疗效对比[J].临床合理用药杂志,2015,8(21):48-49.
[15]王健.苯磺酸氨氯地平片联合美托洛尔缓释片治疗原发性高血压并舒张性心力衰竭的临床疗效评价[J].临床合理用药杂志,2015,10(21):1-2.
[2]黄秀晶.原发性高血压应用氨氯地平与美托洛尔的治疗评价[J].中国医药指南,2015,23(11):107-108.
[3]罗红敏.顽固性高血压的发病率及其防治[J].中国危重病急救医学,2012,24(4):236.
[4]张瑛丽.应用氨氯地平与美托洛尔治疗原发性高血压的临床体会[J].中国医药指南,2015,13(11):66-67.
[5]王家祺,梁永,欧阳征,等.氨氯地平联合美托洛尔治疗原发性高血压的临床疗效观察[J].现代生物医学进展,2013,12(28):5571-5573,5581.
[6]刘力生.中国高血压防治指南2010[J].中华高血压杂志,2011,19(8):701-708.
[7]袁忠伟.美托洛尔与左旋氨氯地平二联疗法用于轻中度原发性高血压治疗临床研究[J].中外医疗,2014,33(24):133-134.
[8]李瑞杰.中国高血压防治指南(2010年修订版)重点内容介绍[J].中国临床医生,2012,40(2):69-72.
[9]李海峰.氯胺地平与美托洛尔联用治疗高血压的效果观察[J].中国现代药物应用,2013,7(4):58-59.
[10]颜艳,王爽,苏爱军,等.厄贝沙坦联合氨氯地平治疗2型糖尿病合并高血压的疗效及对糖代谢和血压的影响[J].现代生物医学进展,2015,13(21):4149-4152.
[11]仁青措.缬沙坦分散片联合美托洛尔治疗原发性高血压合并冠心病疗效观察[J].深圳中西医结合杂志,2014,28(8):143-144.
[12]赵仙先.合理用药有效控制高血压[J].健康向导,2014,20(6):20-21.
[13]李其利.不同降压药物对原发性高血压患者心率变应性的影响[J].心血管病防治知识,2014,10(10):22-23.
[14]郑细优,黄春平.不同剂量美托洛尔治疗原发性高血压的疗效对比[J].临床合理用药杂志,2015,8(21):48-49.
[15]王健.苯磺酸氨氯地平片联合美托洛尔缓释片治疗原发性高血压并舒张性心力衰竭的临床疗效评价[J].临床合理用药杂志,2015,10(21):1-2.