脑小血管病患者脑微出血与步态障碍的相关性分析
摘要
目的探讨脑小血管病患者脑微出血与步态障碍之间的关系。方法选择脑小血管病患者87例,通过对患者进行头颅MRI检查以及定量和临床步态参数的测量,比较脑微出血病灶数目及部位与步长、步宽、步频、步速及临床步态量表的相关性。结果微出血数目与步长、步宽和Tinetti POMA、TUGT有明显相关性(P均<0.05),与步速、步频无明显相关性。额叶、颞叶、基底节微出血灶与步长、步宽及Tinetti POMA、TUGT有明显相关性(P均<0.05),与步速、步频无明显相关性(P均>0.05)。结论脑微出血作为独立因素和脑小血管病患者的步态障碍有相关性。
引文
[1] de Laat KF,van Norden AG,Gons RA,et al.Gait in elderly with cerebral small vessel disease[J].Stroke,2010,41(8):1652-1658
[2] de Laat KF,van den Berg HA,van Norden AG,et al.Microbleeds are independently related to gait disturbances in elderly individuals with cerebral small vessel disease[J].Stroke,2011,42(2):494-497
[3] 孙芳,郭会映,何月,等.高龄脑小血管病患者脑微出血与步态障碍的相关性分析[J].中华老年心脑血管病杂志,2014,16(5):507-509
[4] 高中宝,赵杏丽,王振福,等.脑微出血与脑白质病变及腔隙性梗死关系研究[J].中国卒中杂志,2015,10(10):822-826
[5] Stijntjes M,de Craen AG,van der Grond J,et al.Cerebral microbleeds and lacunar infarcts are associated with walking speed independent of cognitive performance in middle-aged to older adults[J].Gerontology,2016,62(5):500-507
[6] Wardlaw JM,Smith EE,Biessels GJ,et al.Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration[J].Lancet Neurol,2013,12(8):822-838
[7] Gregoire SM,Chaudhary UJ,Brown MM,et al.The Microbleed Anatomical Rating Scale (MARS):Reliability of a tool to map brain microbleeds[J].Neurology,2009,73(21):1759-1766
[8] Canbek J,Fulk G,Nof L,et al.Test-retest reliability and construct validity of the tinetti performance-oriented mobility assessment in people with stroke[J].Neurol Phys Ther,2013,37(1):14-19
[9] Alexander NB,Goldberg A.Gait disorders:search for m-ultiple causes[J].Cleve Clin J Med,2005,72(7):586;589-590
[10] Pantoni L.Cerebral small vessel disease:from pathogenesis and clinical characteristics to therapeutic challenges[J].Lancet Neurol,2010,9(7):689-701
[11] Shi Y,Wardlaw JM.Update on cerebral small vessel disease:a dynamic whole-brain disease[J].Stroke Vasc Neurol,2016,1(3):e000035
[12] 宗黎霞,姜坤,崔丽英,等.57例脑小血管病患者步态及平衡障碍特征分析[J].中国卒中杂志,2015,10(12):1000-1005
[13] van der Holst HM,Tuladhar AM,Zerbi V,et al.White matter changes and gait decline in cerebral small vessel disease[J].Neuroimage Clin,2018,17:731-738
[14] de Laat KF,Tuladhar AM,van Norden AG,et al.Loss of white matter integrity is associated with gait disorders in cerebral small vessel disease[J].Brain,2011,134(Pt1):73-83
[15] de Laat KF,van Norden AG,Gons RA,et al.Diffusion Tensor Imaging and Gait in Elderly Persons With Cerebral Small Vessel Disease[J].Stroke,2011,42(2):373-379
[2] de Laat KF,van den Berg HA,van Norden AG,et al.Microbleeds are independently related to gait disturbances in elderly individuals with cerebral small vessel disease[J].Stroke,2011,42(2):494-497
[3] 孙芳,郭会映,何月,等.高龄脑小血管病患者脑微出血与步态障碍的相关性分析[J].中华老年心脑血管病杂志,2014,16(5):507-509
[4] 高中宝,赵杏丽,王振福,等.脑微出血与脑白质病变及腔隙性梗死关系研究[J].中国卒中杂志,2015,10(10):822-826
[5] Stijntjes M,de Craen AG,van der Grond J,et al.Cerebral microbleeds and lacunar infarcts are associated with walking speed independent of cognitive performance in middle-aged to older adults[J].Gerontology,2016,62(5):500-507
[6] Wardlaw JM,Smith EE,Biessels GJ,et al.Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration[J].Lancet Neurol,2013,12(8):822-838
[7] Gregoire SM,Chaudhary UJ,Brown MM,et al.The Microbleed Anatomical Rating Scale (MARS):Reliability of a tool to map brain microbleeds[J].Neurology,2009,73(21):1759-1766
[8] Canbek J,Fulk G,Nof L,et al.Test-retest reliability and construct validity of the tinetti performance-oriented mobility assessment in people with stroke[J].Neurol Phys Ther,2013,37(1):14-19
[9] Alexander NB,Goldberg A.Gait disorders:search for m-ultiple causes[J].Cleve Clin J Med,2005,72(7):586;589-590
[10] Pantoni L.Cerebral small vessel disease:from pathogenesis and clinical characteristics to therapeutic challenges[J].Lancet Neurol,2010,9(7):689-701
[11] Shi Y,Wardlaw JM.Update on cerebral small vessel disease:a dynamic whole-brain disease[J].Stroke Vasc Neurol,2016,1(3):e000035
[12] 宗黎霞,姜坤,崔丽英,等.57例脑小血管病患者步态及平衡障碍特征分析[J].中国卒中杂志,2015,10(12):1000-1005
[13] van der Holst HM,Tuladhar AM,Zerbi V,et al.White matter changes and gait decline in cerebral small vessel disease[J].Neuroimage Clin,2018,17:731-738
[14] de Laat KF,Tuladhar AM,van Norden AG,et al.Loss of white matter integrity is associated with gait disorders in cerebral small vessel disease[J].Brain,2011,134(Pt1):73-83
[15] de Laat KF,van Norden AG,Gons RA,et al.Diffusion Tensor Imaging and Gait in Elderly Persons With Cerebral Small Vessel Disease[J].Stroke,2011,42(2):373-379