黄褐斑发病机制研究进展
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摘要
黄褐斑是一种好发于颜面等暴露部位的色素增加性皮肤病,不仅影响外观,对工作生活也带来一定困拢。黄褐斑确切发病机制尚不完全明确。近年研究结果表明,表皮屏障破坏、炎症反应、血管改变、光老化、细胞自噬、非紫外线光热源及氧化应激因素在黄褐斑发病过程中也有重要意义。本文综述回顾近几年关于黄褐斑发病机制的文献,以期对黄褐斑的认识及治疗提供帮助。
引文
[1]中国中西医结合学会皮肤性病专业委员会色素病学组,中国黄褐斑治疗专家共识(2015)[J].中华皮肤科杂志,2016,49(8):529-532.
[2]Groen D,Poole DS,Gooris GS,et al.Investigating the barrier function of skin lipid models with varying compositions[J].Eur JPharm Biopharm,2011,79:334-342.
[3]Kang HY,Suzuki I,Lee DJ,et al.Transcriptional profiling shows altered expression of wnt pathway-and lipid metabolism-related genes as well as melanogenesis-related genes in melasma[J].J Invest Dermatol,2011,131:1 692-1 700.
[4]Piao MJ,Zhang R,Lee NH,et al.Protective effect of triphloretholA against ultraviolet B-mediated damage of human keratinocytes[J].J Photochem Photobiol B,2012,5,106:74-80.
[5]宋秀祖,许爱娥.黄褐斑:表皮屏障与黑素屏障失衡[J].国际皮肤性病学杂志,2012,38(5):310-312.
[6]王银娟,顾华,郭美华,等.黄褐斑患者皮损及血液中Toll样受体2和4的表达[J].中华皮肤科杂志,2015,48(2):100-103.
[7]Rodríguez-Arámbula A,Torres-魣lvarez B,Cortés-García D,et al.CD4,IL-17,and COX-2 are associated with subclinical inflammation in malar melasma[J].Am J Dermatopathol,2015,37:761-766.
[8]何黎.黄褐斑诊治新思路[J].皮肤病与性病,2012,34(1):13-14.
[9]Kang HY,Bahadoran P,Suzuki I,et al.In vivo reflectance confocal microscopy detects pigmentary changes in melasma at a cellular level resolution[J].Exp Dermatol,2010,19:e228-233.
[10]朱丽萍,庞勤,吕乐春,等.黄褐斑患者组织病理特征分析[J].中华皮肤科杂志,2016,49(10):706-711.
[11]Na JI,Choi SY,Yang SH,et al.Effect of tranexamic acid on melasma:a clinical trial with histological evaluation[J].J Eur Acad Dermatol Venereol,2013,27:1 035-1 039.
[12]刘媛,李福民,廖金凤,等.皮肤光老化机制研究进展[J].临床皮肤科杂志,2016(6):479-481.
[13]Kang HY,Ortonne JP.What should be considered in treatment of melasma[J].Ann Dermatol,2010,22:373-378.
[14]Torres-Alvarez B,Mesa-Garza IG,Castanedo-Cázares JP,et al.Histochemical and immunohistochemical study in melasma:evidence of damage in the basal membrane[J].Am J Dermatopathol,2011,33:291-295.
[15]Briganti S,Flori E,Mastrofrancesco A,et al.Azelaic acid reduced senescence-like phenotype in photo-irradiated human dermal fibroblasts:possible implication of PPARγ[J].Exp Dermatol,2013,22:41-47.
[16]Kim KH,Bin BH,Kim J,et al.Novel inhibitory function of miR-125b in melanogenesis[J].Pigment Cell Melanoma Res,2014,27:140-144.
[17]Kim NH,Choi SH,Yi N,et al.Arginase-2,a miR-1299 target,enhances pigmentation in melasma by reducing melanosome degradation via senescence-induced autophagy inhibition[J].Pigment Cell Melanoma Res,2017,30:521-530.
[18]Cho YH,Park JE,Lim DS,et al.Tranexamic acid inhibits melanogenesis by activating the autophagy system in cultured melanoma cells[J].J Dermatol Sci,2017,88:96-102.
[19]Chen L,Xu Z,Jiang M,et al.Light-emitting diode 585 nm photomodulation inhibiting melanin synthesis and inducing autophagy in human melanocytes[J].J Dermatol Sci,2018,89:11-18.
[20]Regazzetti C,Sormani L,Debayle D,et al.Melanocytes sense blue light and regulate pigmentation through the Opsin-3[J].J Invest Dermatol,2018,138:171-178.
[21]Boukari F,Jourdan E,Fontas E,et al.Prevention of melasma relapses with sunscreen combining protection against UV and short wavelengths of visible light:a prospective randomized comparative trial[J].J Am Acad Dermatol,2015,72:189-190.
[22]Handel AC,Miot LD,Miot HA.Melasma:a clinical and epidemiological review[J].An Bras Dermatol,2014,89:771-782.
[23]Se觭kin HY,Kalkan G,Ba覨s Y.Oxidative stress status in patients with melasma[J].Cutan Ocul Toxicol,2014,33:212-217.
[24]Choubey V,Sarkar R,Garg V,et al.Role of oxidative stress in melasma:a prospective study on serum and blood markers of oxidative stress in melasma patients[J].Int J Dermatol,2017,56:939-943.
[2]Groen D,Poole DS,Gooris GS,et al.Investigating the barrier function of skin lipid models with varying compositions[J].Eur JPharm Biopharm,2011,79:334-342.
[3]Kang HY,Suzuki I,Lee DJ,et al.Transcriptional profiling shows altered expression of wnt pathway-and lipid metabolism-related genes as well as melanogenesis-related genes in melasma[J].J Invest Dermatol,2011,131:1 692-1 700.
[4]Piao MJ,Zhang R,Lee NH,et al.Protective effect of triphloretholA against ultraviolet B-mediated damage of human keratinocytes[J].J Photochem Photobiol B,2012,5,106:74-80.
[5]宋秀祖,许爱娥.黄褐斑:表皮屏障与黑素屏障失衡[J].国际皮肤性病学杂志,2012,38(5):310-312.
[6]王银娟,顾华,郭美华,等.黄褐斑患者皮损及血液中Toll样受体2和4的表达[J].中华皮肤科杂志,2015,48(2):100-103.
[7]Rodríguez-Arámbula A,Torres-魣lvarez B,Cortés-García D,et al.CD4,IL-17,and COX-2 are associated with subclinical inflammation in malar melasma[J].Am J Dermatopathol,2015,37:761-766.
[8]何黎.黄褐斑诊治新思路[J].皮肤病与性病,2012,34(1):13-14.
[9]Kang HY,Bahadoran P,Suzuki I,et al.In vivo reflectance confocal microscopy detects pigmentary changes in melasma at a cellular level resolution[J].Exp Dermatol,2010,19:e228-233.
[10]朱丽萍,庞勤,吕乐春,等.黄褐斑患者组织病理特征分析[J].中华皮肤科杂志,2016,49(10):706-711.
[11]Na JI,Choi SY,Yang SH,et al.Effect of tranexamic acid on melasma:a clinical trial with histological evaluation[J].J Eur Acad Dermatol Venereol,2013,27:1 035-1 039.
[12]刘媛,李福民,廖金凤,等.皮肤光老化机制研究进展[J].临床皮肤科杂志,2016(6):479-481.
[13]Kang HY,Ortonne JP.What should be considered in treatment of melasma[J].Ann Dermatol,2010,22:373-378.
[14]Torres-Alvarez B,Mesa-Garza IG,Castanedo-Cázares JP,et al.Histochemical and immunohistochemical study in melasma:evidence of damage in the basal membrane[J].Am J Dermatopathol,2011,33:291-295.
[15]Briganti S,Flori E,Mastrofrancesco A,et al.Azelaic acid reduced senescence-like phenotype in photo-irradiated human dermal fibroblasts:possible implication of PPARγ[J].Exp Dermatol,2013,22:41-47.
[16]Kim KH,Bin BH,Kim J,et al.Novel inhibitory function of miR-125b in melanogenesis[J].Pigment Cell Melanoma Res,2014,27:140-144.
[17]Kim NH,Choi SH,Yi N,et al.Arginase-2,a miR-1299 target,enhances pigmentation in melasma by reducing melanosome degradation via senescence-induced autophagy inhibition[J].Pigment Cell Melanoma Res,2017,30:521-530.
[18]Cho YH,Park JE,Lim DS,et al.Tranexamic acid inhibits melanogenesis by activating the autophagy system in cultured melanoma cells[J].J Dermatol Sci,2017,88:96-102.
[19]Chen L,Xu Z,Jiang M,et al.Light-emitting diode 585 nm photomodulation inhibiting melanin synthesis and inducing autophagy in human melanocytes[J].J Dermatol Sci,2018,89:11-18.
[20]Regazzetti C,Sormani L,Debayle D,et al.Melanocytes sense blue light and regulate pigmentation through the Opsin-3[J].J Invest Dermatol,2018,138:171-178.
[21]Boukari F,Jourdan E,Fontas E,et al.Prevention of melasma relapses with sunscreen combining protection against UV and short wavelengths of visible light:a prospective randomized comparative trial[J].J Am Acad Dermatol,2015,72:189-190.
[22]Handel AC,Miot LD,Miot HA.Melasma:a clinical and epidemiological review[J].An Bras Dermatol,2014,89:771-782.
[23]Se觭kin HY,Kalkan G,Ba覨s Y.Oxidative stress status in patients with melasma[J].Cutan Ocul Toxicol,2014,33:212-217.
[24]Choubey V,Sarkar R,Garg V,et al.Role of oxidative stress in melasma:a prospective study on serum and blood markers of oxidative stress in melasma patients[J].Int J Dermatol,2017,56:939-943.