卵巢无性细胞瘤4例分析
摘要
<正>无性细胞瘤是一种最常见的恶性原始生殖细胞肿瘤,但仅占卵巢所有恶性肿瘤的1%～2%,肿瘤细胞无特异性分化模式[1]。因临床较为罕见,为避免误诊、漏诊,本文回顾性分析4例无性细胞瘤的临床病理资料,同时复习相关文献,探讨其临床病理学特点、诊断与鉴别诊断要点及预后。1材料与方法1. 1材料收集安徽医科大学附属妇幼保健院2014—2018年病理诊断的卵巢无性细胞瘤4例,复
引文
[1] Kurman RJ,Carcangiu ML,Herrington CS,et al.WHO classification of tumours of female reproductive organs [M].4th. Lyon: IRAC Press,2014.57-58.
[2] 吴永芳,许春伟,邵云,等.卵巢无性细胞瘤临床病理分析并文献复习[J].临床与病理杂志,2015, 35(8):1585-1590.
[3] Shah R, Xia C, Krailo M, et al. Is carboplatin-based chemotherapy as effective as cisplatin-based chemotherapy in the treatment of advanced-stage dysgerminoma in children, adolescents and young adults[J]. Gynecol Oncol, 2018,150(2):253-260.
[4] 齐冬雪,张春芳,张昶,等. SALL4、CD30、D2-40 和glypican-3在卵巢生殖细胞肿瘤中的表达及应用[J].诊断病理学杂志,2017,24(5):358-362.
[5] Kamal NM, Khan U, Mirza S, et al. Ovarian dysgerminoma with normal serum tumour markers presenting in a child with precocious puberty [J]. J Cancer Res Ther, 2015,11(3):661-663.
[6] Mili F, Nobari N, Abdollahi A. Pseudopapillary and macrofollicular microscopic growth patterns in an advanced stage ovarian dysgerminoma: a case report [J]. Iran J Pathol, 2018,13(1):94-98.
[7] McCuaig JM,Noor A,Rosen B, et al. Case report: use of tumor and germline Y chromosomal analysis to guide surgical management in a 46, XX female presenting with gonadoblastoma with dysgerminoma [J]. Int J Gynecol Pathol,2017,36(5):466-470.
[8] He Y, Xu L, Li Q, et al. Synchronous adrenocortical carcinoma and ovarian malignant mixed germ cell tumor: a case report and literature review[J]. Medicine (Baltimore), 2018, 97(20):e10730.
[9] 郭丽娜. 妇产科疾病诊断病理学[M].第2版. 北京:人民卫生出版社,2014.162-163.
[10] Nosratian-Baskovic M, Tan B, Folkins A, et al. Hemophagocytic lymphohistiocytosis as a paraneoplastic syndrome associated with ovarian dysgerminoma [J]. Gynecol Oncol Rep, 2016,17(4):38-41.
[11] Julia CR, Maria Dei CJ, Racionero CMA. Death by bleomycin pulmonary toxicity in ovarian dysgerminoma with pathologic complete response to chemotherapy: a case report [J]. Respir Med Case Rep, 2016,18:48-50.
[12] Yüce ?, D?gér E, ?elik N, et al. Gonadoblastoma with dysgerminoma in a phenotypically turner-like girl with 45,X/46,XY karyotype [J]. J Clin Res Pediatr Endocrinol, 2015,7(4):336-339.
[13] Ebert KM, Hewitt GD, Indyk JA, et al. Normal pelvic ultrasound or MRI does not rule out neoplasm in patients with gonadal dysgenesis and Y chromosome material[J]. J Pediatr Urol, 2018,14(2): 154.e1-154.e6.
[14] Gonzalez-Benitez C, De La Iglesia E, De Santiago J, et al. Dysgerminoma on a gonadoblastoma in a patient with Swyer syndrome treated with single incision laparoscopic surgery [J]. J Obstet Gynaecol, 2015,35(1):102-103.
[15] Chen Y, Luo Y, Han C, et al. Ovarian dysgerminoma in pregnancy: a case report and literature review [J]. Cancer Biol Ther, 2018, 26:1-28.
[16] Stafman LL, Maizlin II, Dellinger M, et al. Disparities in fertility-sparing surgery in adolescent and young women with stage I ovarian dysgerminoma [J]. J Surg Res, 2018,224:38-43.
[17] Gupta M, Jindal R, Saini V. An incidental finding of bilateral dysgerminoma during cesarean section: dilemmas in management [J]. J Clin Diagn Res, 2016,10(8): 04-05.
[2] 吴永芳,许春伟,邵云,等.卵巢无性细胞瘤临床病理分析并文献复习[J].临床与病理杂志,2015, 35(8):1585-1590.
[3] Shah R, Xia C, Krailo M, et al. Is carboplatin-based chemotherapy as effective as cisplatin-based chemotherapy in the treatment of advanced-stage dysgerminoma in children, adolescents and young adults[J]. Gynecol Oncol, 2018,150(2):253-260.
[4] 齐冬雪,张春芳,张昶,等. SALL4、CD30、D2-40 和glypican-3在卵巢生殖细胞肿瘤中的表达及应用[J].诊断病理学杂志,2017,24(5):358-362.
[5] Kamal NM, Khan U, Mirza S, et al. Ovarian dysgerminoma with normal serum tumour markers presenting in a child with precocious puberty [J]. J Cancer Res Ther, 2015,11(3):661-663.
[6] Mili F, Nobari N, Abdollahi A. Pseudopapillary and macrofollicular microscopic growth patterns in an advanced stage ovarian dysgerminoma: a case report [J]. Iran J Pathol, 2018,13(1):94-98.
[7] McCuaig JM,Noor A,Rosen B, et al. Case report: use of tumor and germline Y chromosomal analysis to guide surgical management in a 46, XX female presenting with gonadoblastoma with dysgerminoma [J]. Int J Gynecol Pathol,2017,36(5):466-470.
[8] He Y, Xu L, Li Q, et al. Synchronous adrenocortical carcinoma and ovarian malignant mixed germ cell tumor: a case report and literature review[J]. Medicine (Baltimore), 2018, 97(20):e10730.
[9] 郭丽娜. 妇产科疾病诊断病理学[M].第2版. 北京:人民卫生出版社,2014.162-163.
[10] Nosratian-Baskovic M, Tan B, Folkins A, et al. Hemophagocytic lymphohistiocytosis as a paraneoplastic syndrome associated with ovarian dysgerminoma [J]. Gynecol Oncol Rep, 2016,17(4):38-41.
[11] Julia CR, Maria Dei CJ, Racionero CMA. Death by bleomycin pulmonary toxicity in ovarian dysgerminoma with pathologic complete response to chemotherapy: a case report [J]. Respir Med Case Rep, 2016,18:48-50.
[12] Yüce ?, D?gér E, ?elik N, et al. Gonadoblastoma with dysgerminoma in a phenotypically turner-like girl with 45,X/46,XY karyotype [J]. J Clin Res Pediatr Endocrinol, 2015,7(4):336-339.
[13] Ebert KM, Hewitt GD, Indyk JA, et al. Normal pelvic ultrasound or MRI does not rule out neoplasm in patients with gonadal dysgenesis and Y chromosome material[J]. J Pediatr Urol, 2018,14(2): 154.e1-154.e6.
[14] Gonzalez-Benitez C, De La Iglesia E, De Santiago J, et al. Dysgerminoma on a gonadoblastoma in a patient with Swyer syndrome treated with single incision laparoscopic surgery [J]. J Obstet Gynaecol, 2015,35(1):102-103.
[15] Chen Y, Luo Y, Han C, et al. Ovarian dysgerminoma in pregnancy: a case report and literature review [J]. Cancer Biol Ther, 2018, 26:1-28.
[16] Stafman LL, Maizlin II, Dellinger M, et al. Disparities in fertility-sparing surgery in adolescent and young women with stage I ovarian dysgerminoma [J]. J Surg Res, 2018,224:38-43.
[17] Gupta M, Jindal R, Saini V. An incidental finding of bilateral dysgerminoma during cesarean section: dilemmas in management [J]. J Clin Diagn Res, 2016,10(8): 04-05.