老年糖尿病患者血同型半胱氨酸与叶酸和维生素B_(12)水平分析
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摘要
目的探讨老年糖尿病患者血清中同型半胱氨酸(Hcy)、叶酸和维生素B_(12)(Vit B_(12))水平的变化及其互相关系。方法对入选的80例糖尿病组以及80例健康对照组分别采集其清晨空腹静脉血清或血浆,-20℃冻存,然后集中测定血同型半胱氨酸、Vit B_(12)、叶酸水平。结果糖尿病组血同型半胱氨酸的测定值明显高于健康对照组,差异有统计学意义(t=6.176,P=0.019);同时糖尿病组叶酸及Vit B_(12)的水平低于健康对照组,差异有统计学意义(叶酸:t=4.289,P=0.035;Vit B_(12):t=3.016,P=0.043);并且血Hcy浓度与叶酸和Vit B_(12)水平呈负相关(叶酸:r=0.920,P=0.025;Vit B_(12):r=0.950,P=0.013)。结论老年糖尿病患者血同型半胱氨酸升高的同时伴有叶酸及Vit B_(12)的降低。
Objective To analyze the changes of serum homocysteine,folic acid and Vit B12 levels in elderly patients with diabetes and their relationship. Methods A total of 80 cases of diabetes group and 80 cases of healthy controls were collected the morning fasting venous blood serum or plasma and blood homocysteine,Vit B12,folic acid level were tested. Results Homocysteine in diabetes group was obviously higher than that of healthy controls,there was statistically significant( t = 6. 176,P = 0. 019),and folic acid and Vit B12 of diabetes group were lower than healthy controls,there were statistically significant( folic acid:t = 4. 289,P = 0. 035;Vit B12:t = 3. 016,P = 0. 043),and the Hcy concentration was negatively correlated with folate and Vit B12 levels( folic acid:r = 0. 92,P = 0. 025;Vit B12:r = 0. 95,P = 0. 013). Conclusion Blood homocysteine in elderly patients with diabetes increases with decreased folic acid and vitamin B12.
Objective To analyze the changes of serum homocysteine,folic acid and Vit B12 levels in elderly patients with diabetes and their relationship. Methods A total of 80 cases of diabetes group and 80 cases of healthy controls were collected the morning fasting venous blood serum or plasma and blood homocysteine,Vit B12,folic acid level were tested. Results Homocysteine in diabetes group was obviously higher than that of healthy controls,there was statistically significant( t = 6. 176,P = 0. 019),and folic acid and Vit B12 of diabetes group were lower than healthy controls,there were statistically significant( folic acid:t = 4. 289,P = 0. 035;Vit B12:t = 3. 016,P = 0. 043),and the Hcy concentration was negatively correlated with folate and Vit B12 levels( folic acid:r = 0. 92,P = 0. 025;Vit B12:r = 0. 95,P = 0. 013). Conclusion Blood homocysteine in elderly patients with diabetes increases with decreased folic acid and vitamin B12.
引文
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[16]OKADAE,OIDA K,TADA H,et al.Hyperhomocysteinemia is a visk factor for coronary are rioselerosis in tapanese patients with type 2 diabetes[J].Diabetes Care,1999,28(12):484.
[17]王杰,张志军.联合应用叶酸和甲钴胺对脑梗塞患者高同型半胱氨酸血症的影响[J].陕西医学杂志,2004,33(12):1118-1119.
[18]张京芬,李月春,刘国荣,等.联合维生素治疗对脑卒中病人高同型半胱氨酸血症的影响[J].脑与神经疾病杂志,2004,12(1):36-37.
[19]陈建栋,陈建中.2型糖尿病患者血清同型半胱氨酸含量与糖尿病肾病关系的探讨[J].标记免疫分析与临床,2016,23(1):19-20.
[20]RYU OH,LEE S,YU J,et al.A prospective randomized controlled trial of the effects of vitamin D supplementation on long-term glycemic control in type 2 diabetes mellitus of Korea[J].Endocr J,2014,61(2):167-176.
[2]薛文郁,柳洁,秦洁.高同型半胱氨酸血症与糖尿病微血管病变的关系[J].山西医药杂志,2009,38(S1):60-62
[3]冯小娟,李海英,蒋玲,等.T2DM患者血清25-(OH)D与Hcy、β2微球蛋白关系及临床意义[J].国际检验医学杂志,2016,37(7):912-914.
[4]王绵,李风英,葛秀兰.高同型半胱氨酸血症与胰岛素抵抗及糖尿病慢性并发症[J].国外医学:内分泌分册,2001,21(3):146.
[5]吴吉萍,方朝晖.血浆同型半胱氨酸与糖尿病血管并发症的关系[J].中国临床保健杂志,2012,15(1):109-112.
[6]赵倩,王卫东,吴曼,等.老年2型糖尿病颈动脉粥样硬化与同型半胱氨酸、胱抑素C、超敏C反应蛋白的关系[J].中国临床保健杂志,2014,17(6):591-594.
[7]高君丽,田静.急性脑梗死患者同型半胱氨酸水平与血脂和颈动脉粥样硬化的关系[J].现代中西医结合杂志,2014,23(4):385-386.
[8]曾春燕,彭冬迪,曹瑞林,等.中青年男性高血压患者血清同型半胱氨酸及尿酸水平变化[J].实用心脑肺血管病杂志,2014,22(2):68-69.
[9]莫善晓.冠心病患者血清同型半胱氨酸、尿酸水平变化及临床意义[J].中外医学研究,2014,12(3):59-60.
[10]陶建平,魏盟,陈歆.同型半胱氨酸与舒张性心力衰竭的相关性[J].临床荟萃,2014,29(2):159-161.
[11]鲍智颖,钟小兵,康平,等.血浆同型半胱氨酸水平与帕金森病的研究[J].中国实用医刊,2014,41(3):24-25.
[12]孙芹敏,王哲,曲梦琦,等.老年痴呆患者血清同型半胱氨酸水平及临床意义[J].中国老年学杂志,2015,35(7):1729-1731.
[13]邹伟,李毅.血同型半胱胺酸与糖尿病及其并发症的相关性探讨[J].世界临床医学,2016,10(2):84.
[14]李媛媛,王琪.同型半胱氨酸及血管内皮功能检测在脑梗死中的应用[J].检验医学,2014,29(10):1028-1030.
[15]王姗姗,王振福,孙虹,等.老年脑梗死患者高同型半胱氨酸血症与动脉粥样硬化斑块的相关性分析[J].中国临床保健杂志,2011,14(4):368-369.
[16]OKADAE,OIDA K,TADA H,et al.Hyperhomocysteinemia is a visk factor for coronary are rioselerosis in tapanese patients with type 2 diabetes[J].Diabetes Care,1999,28(12):484.
[17]王杰,张志军.联合应用叶酸和甲钴胺对脑梗塞患者高同型半胱氨酸血症的影响[J].陕西医学杂志,2004,33(12):1118-1119.
[18]张京芬,李月春,刘国荣,等.联合维生素治疗对脑卒中病人高同型半胱氨酸血症的影响[J].脑与神经疾病杂志,2004,12(1):36-37.
[19]陈建栋,陈建中.2型糖尿病患者血清同型半胱氨酸含量与糖尿病肾病关系的探讨[J].标记免疫分析与临床,2016,23(1):19-20.
[20]RYU OH,LEE S,YU J,et al.A prospective randomized controlled trial of the effects of vitamin D supplementation on long-term glycemic control in type 2 diabetes mellitus of Korea[J].Endocr J,2014,61(2):167-176.