化妆品中36种挥发性有机溶剂残留的测定
|
摘要
建立双柱定性-顶空气相色谱质谱联用仪法测定化妆品中36种挥发性有机溶剂残留的方法。使用极性柱VF-1301 ms和非极性柱DB-5 ms两根色谱柱,考察挥发性有机溶剂残留的保留时间以定性,再利用VF-1301 ms柱对存在的残留溶剂进行定量测定。所建立的方法在相应的浓度范围内浓度和峰面积的线性关系良好,线性相关系数为0.999 1～0.999 7,加标回收率在82.0%～117.6%之间,相对标准偏差为1.1%～2.9%,检出限为0.08～29.24μg/g。该方法检测结果准确、可靠,适用于多种常用化妆品挥发性有机溶剂的同时测定。
A method to determine 36 kinds of volatile organic solvents residues was established by headspace gas chromatography mass spectrometry(HS-GC/MS) with dual-column identification.For qualitative analysis,the retention times of these volatile organic solvents residues were determined by using two columns:polar column VF-1301 ms and non-polar column DB-5 ms.For quantitative analysis,the amount of these volatile organic solvents residues were determined by the VF-1301 ms column respectively.The established method has a good linear relationship between concentration and peak area in the corresponding concentration range.The linear correlation coefficients were from 0.999 1 to 0.999 7.The recoveries were between 82.0% and 117.6%,and the relative standard deviations were from 1.1% to 2.9%.The detection limit were from 0.08 μg/g to 29.24 μg/g.The method had accurate and reliable detection results and was suitable for the analysis of a variety of volatile organic solvents in common use of cosmetics.
A method to determine 36 kinds of volatile organic solvents residues was established by headspace gas chromatography mass spectrometry(HS-GC/MS) with dual-column identification.For qualitative analysis,the retention times of these volatile organic solvents residues were determined by using two columns:polar column VF-1301 ms and non-polar column DB-5 ms.For quantitative analysis,the amount of these volatile organic solvents residues were determined by the VF-1301 ms column respectively.The established method has a good linear relationship between concentration and peak area in the corresponding concentration range.The linear correlation coefficients were from 0.999 1 to 0.999 7.The recoveries were between 82.0% and 117.6%,and the relative standard deviations were from 1.1% to 2.9%.The detection limit were from 0.08 μg/g to 29.24 μg/g.The method had accurate and reliable detection results and was suitable for the analysis of a variety of volatile organic solvents in common use of cosmetics.
引文
[1] 许瑛华,朱炳辉,钟秀华,等.顶空气相色谱法测定化妆品中15种挥发性有机溶剂残留[J].色谱,2010,28(1):73-77.
[2] 达晶,黄湘鹭,王钢力,等.化妆品中挥发性有机溶剂的通用检测方法[J].色谱,2014,32(11):1251-1259.
[3] 国家食品药品监督管理总局.化妆品安全技术规范[M].2015版.北京:国家食品药品监督管理总局,2016.
[4] 白璐,廖林川,颜有仪,等.挥发性有机溶剂的危害及滥用[J].证据科学,2005,12(2):135-136.
[5] 王敏,邢燕,王钟,等.双柱定性-气相色谱测定蔬菜中多种农药残留[J].食品研究与开发,2016,37(20):141-144.
[6] 孙军,潘玉香,朱莉萍,等.气相色谱双塔双柱同时测定蔬菜中多种有机氯及拟除虫菊酯类农药残留量[J].分析试验室,2007,26(8):56-60.
[7] 陈华宜,许瑛华.化妆品中有毒挥发性有机溶剂标准检验方法的验证研究[J].中国卫生检验杂志,2009(7):1466-1469.
[8] 车文军,沈珺,王燕芹,等.静态顶空/气相色谱-质谱法同时测定化妆品中22种有毒挥发性有机溶剂残留[J].分析测试学报,2017,36(5):697-700.
[9] 李润岩,范斌,蔡立鹏,等.顶空-气相色谱-质谱法测定化妆品中14种挥发性有机化合物的残留量[J].理化检验(化学分册),2014,50(7):852-856.
[10] 龙耀庭.一种双柱定性气相色谱仪的方案[J].分析仪器,1977(4):47-49.
[11] 王琪慧,李铭,詹雪芳.顶空气相色谱-质谱联用法测定清洁类化妆品中的环氧丙烷[J].日用化学工业,2016,46(1):58-60.
[12] 刘永明,葛娜,王飞,等.顶空气相色谱-质谱法同时测定蜂蜜中57种挥发性有机溶剂残留[J].色谱,2012,30(8):782-791.
[13] 夏俊鹏,吴飞,邵爱梅,等.气相色谱-质谱法测定指甲油中17种挥发性有机溶剂[J].理化检验(化学分册),2013,49(11):1297-1300.
[14] 沈珺,车文军,王燕芹,等.静态顶空-气相色谱-质谱法同时测定香精香料中14种有毒挥发性有机溶剂残留[J].食品科学,2017,38(24):302-306.
[15] 李伟,许华,常宇文,等.顶空-气相色谱法同时测定塑料食品包装袋中11种有机溶剂残留量[J].化学试剂,2007,29(8):481-482.
[2] 达晶,黄湘鹭,王钢力,等.化妆品中挥发性有机溶剂的通用检测方法[J].色谱,2014,32(11):1251-1259.
[3] 国家食品药品监督管理总局.化妆品安全技术规范[M].2015版.北京:国家食品药品监督管理总局,2016.
[4] 白璐,廖林川,颜有仪,等.挥发性有机溶剂的危害及滥用[J].证据科学,2005,12(2):135-136.
[5] 王敏,邢燕,王钟,等.双柱定性-气相色谱测定蔬菜中多种农药残留[J].食品研究与开发,2016,37(20):141-144.
[6] 孙军,潘玉香,朱莉萍,等.气相色谱双塔双柱同时测定蔬菜中多种有机氯及拟除虫菊酯类农药残留量[J].分析试验室,2007,26(8):56-60.
[7] 陈华宜,许瑛华.化妆品中有毒挥发性有机溶剂标准检验方法的验证研究[J].中国卫生检验杂志,2009(7):1466-1469.
[8] 车文军,沈珺,王燕芹,等.静态顶空/气相色谱-质谱法同时测定化妆品中22种有毒挥发性有机溶剂残留[J].分析测试学报,2017,36(5):697-700.
[9] 李润岩,范斌,蔡立鹏,等.顶空-气相色谱-质谱法测定化妆品中14种挥发性有机化合物的残留量[J].理化检验(化学分册),2014,50(7):852-856.
[10] 龙耀庭.一种双柱定性气相色谱仪的方案[J].分析仪器,1977(4):47-49.
[11] 王琪慧,李铭,詹雪芳.顶空气相色谱-质谱联用法测定清洁类化妆品中的环氧丙烷[J].日用化学工业,2016,46(1):58-60.
[12] 刘永明,葛娜,王飞,等.顶空气相色谱-质谱法同时测定蜂蜜中57种挥发性有机溶剂残留[J].色谱,2012,30(8):782-791.
[13] 夏俊鹏,吴飞,邵爱梅,等.气相色谱-质谱法测定指甲油中17种挥发性有机溶剂[J].理化检验(化学分册),2013,49(11):1297-1300.
[14] 沈珺,车文军,王燕芹,等.静态顶空-气相色谱-质谱法同时测定香精香料中14种有毒挥发性有机溶剂残留[J].食品科学,2017,38(24):302-306.
[15] 李伟,许华,常宇文,等.顶空-气相色谱法同时测定塑料食品包装袋中11种有机溶剂残留量[J].化学试剂,2007,29(8):481-482.