肾上腺素能β3受体Trp64Arg基因多态性与中国人群高血压病关系的Meta分析
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摘要
目的综合评价肾上腺素能β3受体(beta 3-adrenergic receptor,β3-AR)Trp64Arg基因多态性与中国人群EH的关系。方法检索2013年9月以前5个中、英文电子数据库中有关β3-AR Trp64Arg基因多态性与中国人群EH关系的病例-对照研究,采用比值比(Odds Ratios,OR)和95%可信区间(Confidence Interval,CI)评价β3-AR Trp64Arg基因多态性与EH易感性的关系。结果共纳入文献12篇,累计病例组3 065例,对照组2 081例;异质性检验各研究间无明显异质性;Meta分析结果表明,EH组与对照组显性模型OR=1.203(95%CI:1.056~1.370,P=0.005);EH组与对照组等位基因模型OR=1.174(95%CI:1.047~1.316,P=0.006)。敏感性分析采用亚组分析法,亚组分析结果显示阳性结论出现在不符合HWE亚组和小样本量研究亚组中。Begg's漏斗图和Egger's检验未见明显发表偏倚。结论β3-AR Trp64Arg基因多态性增加中国人群EH易感性。
Objective The study aimed to assess the association between Trp64 Arg gene polymorphism of the beta-3 adrenergic receptor(β3-AR) and essential hypertension(EH) in the Chinese population. Methods Case-control studies on the association between β3-AR Trp64 Arg gene polymorphism and EH among the Chinese population published before September of 2013 were retrieved from five electronic Chinese and English databases. Odds ratios(ORs) and confidence intervals(CIs) were used to evaluate the correlation between β3-AR Trp64 Arg polymorphism and EH susceptibility. Results A total of 12 articles, consisting of 3065 cases and 2081 controls, were included. No significant heterogeneity was detected by heterogeneity test. Meta-analysis of the results showed that OR=1.203 in the dominant model of the EH group and control(95% CI: 1.056-1.370, P=0.005) and that OR=1.174 in the allele model(95% CI: 1.047-1.316, P=0.006). Sensitivity analysis was carried out by subgroup analysis, which showed that positive results occurred in subgroups that were not consistent with the HWE or were from studies with small sample sizes. No significant publication bias was observed in funnel plot of the Begg's test and Egger's test. Conclusion β3-AR Trp64 Arg gene polymorphism increases EH susceptibility in the Chinese population.
Objective The study aimed to assess the association between Trp64 Arg gene polymorphism of the beta-3 adrenergic receptor(β3-AR) and essential hypertension(EH) in the Chinese population. Methods Case-control studies on the association between β3-AR Trp64 Arg gene polymorphism and EH among the Chinese population published before September of 2013 were retrieved from five electronic Chinese and English databases. Odds ratios(ORs) and confidence intervals(CIs) were used to evaluate the correlation between β3-AR Trp64 Arg polymorphism and EH susceptibility. Results A total of 12 articles, consisting of 3065 cases and 2081 controls, were included. No significant heterogeneity was detected by heterogeneity test. Meta-analysis of the results showed that OR=1.203 in the dominant model of the EH group and control(95% CI: 1.056-1.370, P=0.005) and that OR=1.174 in the allele model(95% CI: 1.047-1.316, P=0.006). Sensitivity analysis was carried out by subgroup analysis, which showed that positive results occurred in subgroups that were not consistent with the HWE or were from studies with small sample sizes. No significant publication bias was observed in funnel plot of the Begg's test and Egger's test. Conclusion β3-AR Trp64 Arg gene polymorphism increases EH susceptibility in the Chinese population.
引文
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[14]陈慧,唐仪,骆杰伟,等.β3肾上腺素能受体基因多态性与高血压病患者首次心脑血管事件的相关性[J].中华临床医师杂志:电子版,2008,2(12):1378-1385.
[15]张晓云,魏芳婧,徐力,等.β3肾上腺素能受体基因Trp64Arg多态性与蒙古族原发性高血压病相关性分析[J].中西医结合心脑血管病杂志,2012,10(6):658-660.
[16]王皓,李梅,王丽娟,等.中国北方汉族人群β3-肾上腺素能受体基因Trp 64Arg多态性与原发性高血压的相关性研究[J].心肺血管病杂志,2013,32(1):41-45.
[17]刘永生,韩洪波,郑立文,等.β3肾上腺素能受体基因多态性与2型糖尿病、原发性高血压发病相关性的研究[J].中国实验诊断学,2013,17(1):82-84.
[18]Aleksovska K,Leoncini E,Bonassi S,et al.Systematic review and meta-analysis of circulating S100B blood levels in schizophrenia[J].PLo S One,2014,9(9):e106342.
[19]ZHU LY,HU LY,LI XL,et al.Relationship between Trp64Arg mutation in the beta 3-adrenergic receptor gene and metabolic syndrome:a seven-year follow-up study[J].Chin Med J,2010,123(17):2375-2378.
[20]Tonolo G,Melisa MG,Secchi G,et al.Association of Trp64Arg b3-adrenergic-receptor gene polymorphism with essential hypertension in the Sardinian population[J].J Hypertension,1999,17(1):33-36.
[21]Ringel J,Kreutz R,Distler A,et al.The Trp64Arg polymorphism of the b3-Adrenergic receptor gene is associated with hypertension in men with type 2 diabetes mellitus[J].Am J Hypertens,2000,13(9):1027-1031.
[2]曹菲菲,韩辉,王芬,等.WNK4基因多态与新疆哈萨克族原发性高血压病的关系[J].中华流行病学杂志,2010,31(4):375-378.
[3]王耕,李立明,胡永华.上海市社区人群高血压危险因素聚集与患病关系的研究[J].中华流行病学杂志,2013,34(4):307-310.
[4]Mirrakhimov AE,Kerimkulova AS,Lunegova OS,et al.An association between TRP64ARG polymorphism of the B3adrenoreceptor gene and some metabolic disturbances[J].Cardiovasc Diabetol,2011,10:89.
[5]丁裕斌,綦岩,窦贵旺,等.ADRB3基因Trp64Arg多态性与日本民族原发性高血压无关[J].西南大学学报:自然科学版,2009,31(4):64-68.
[6]Thomas GN,Tomlinson B,Chan JC,et al.The Trp64Arg polymorphism of the beta3-adrenergic receptor gene and obesity in Chinese subjects with componnts of the metabolic syndrome[J].Int J Obes Relat Metab Disord,2000,24:545-551.
[7]王明琴,徐文玲.高血压病,冠心病与β3肾上腺素能受体基因Trp64Arg突变的相关性研究[J].铁道医学,2001,29(4):225-227.
[8]王瑶,萧建中,李光伟.原发性高血压人群胰岛素抵抗与β3-肾上腺素能受体基因多态性的关联[J].中华内分泌代谢杂志,2001,17(3):148-150.
[9]梁宇,赵彦艳,刘洪,等.β肾上腺素能受体基因家族在中国东北高血压病高发人群中的基因型分析[J].中华医学遗传学杂志,2004,21(2):124-127.
[10]谭虹,陈富荣,唐其东,等.β3肾上腺素能受体基因多态性与高血压病相关性研究[J].实用医学杂志,2005,21(1):35-36.
[11]郭艳英,赵蕾,王坤,等.β3肾上腺素能受体基因多态性与新疆哈萨克族人群高血压病的相关研究[J].国际遗传学杂志,2006,29(6):476-477.
[12]刘昭前,莫玮,俞群军,等.β3肾上腺素受体遗传多态性与肥胖和高血压的相关性研究[J].中国现代医学杂志,2006,16(12):1811-1814.
[13]牛永红,谢正祥,殷跃辉.β肾上腺素能受体基因多态性与原发性高血压的关系[J].中国组织工程研究与临床康复,2007,11(12):2243-2246.
[14]陈慧,唐仪,骆杰伟,等.β3肾上腺素能受体基因多态性与高血压病患者首次心脑血管事件的相关性[J].中华临床医师杂志:电子版,2008,2(12):1378-1385.
[15]张晓云,魏芳婧,徐力,等.β3肾上腺素能受体基因Trp64Arg多态性与蒙古族原发性高血压病相关性分析[J].中西医结合心脑血管病杂志,2012,10(6):658-660.
[16]王皓,李梅,王丽娟,等.中国北方汉族人群β3-肾上腺素能受体基因Trp 64Arg多态性与原发性高血压的相关性研究[J].心肺血管病杂志,2013,32(1):41-45.
[17]刘永生,韩洪波,郑立文,等.β3肾上腺素能受体基因多态性与2型糖尿病、原发性高血压发病相关性的研究[J].中国实验诊断学,2013,17(1):82-84.
[18]Aleksovska K,Leoncini E,Bonassi S,et al.Systematic review and meta-analysis of circulating S100B blood levels in schizophrenia[J].PLo S One,2014,9(9):e106342.
[19]ZHU LY,HU LY,LI XL,et al.Relationship between Trp64Arg mutation in the beta 3-adrenergic receptor gene and metabolic syndrome:a seven-year follow-up study[J].Chin Med J,2010,123(17):2375-2378.
[20]Tonolo G,Melisa MG,Secchi G,et al.Association of Trp64Arg b3-adrenergic-receptor gene polymorphism with essential hypertension in the Sardinian population[J].J Hypertension,1999,17(1):33-36.
[21]Ringel J,Kreutz R,Distler A,et al.The Trp64Arg polymorphism of the b3-Adrenergic receptor gene is associated with hypertension in men with type 2 diabetes mellitus[J].Am J Hypertens,2000,13(9):1027-1031.