颈椎后凸畸形动物模型的研究进展
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摘要
<正>颈椎后凸畸形的形成与局部的颈椎退变、创伤、肿瘤、发育畸形以及医源性(颈椎前后路手术)因素有关,系统性疾病如强直性脊柱炎、类风湿关节炎也会导致本病的发生~([1])。其临床表现因原发疾病不同而表现各异,主要为颈痛、肩痛和神经压迫症状,严重的出现chin-on-chest(下
引文
1.Han K,Lu C,Li J,et al.Surgical treatment of cervical kyphosis[J].Eur Spine J,2011,20(4):523-536.
2.Ailon T,Smith JS,Shaffrey CI,et al.Outcomes of operative treatment for adultcervical deformity:a prospective multicenter assessment with 1-year follow-up[J].Neurosurgery,2018,83(5):1031-1039.
3.Cuéllar JM,Lanman TH."Text neck":an epidemic of the moder-nera of cell phones?[J].Spine J,2017,17(6):901-902.
4.Smith JS,Klineberg E,Shaffrey CI,et al.Assessment of surgical treatmentstrategies for moderate to severe cervical spinal deformity reveals marked variatio-nin approaches,osteotomies,and fusion levels[J].World Neurosurg,2016,91:228-237.
5.贾连顺.浅谈颈椎后凸畸形基本概念与诊断学基础[J].脊柱外科杂志,2010,8(2):126-128.
6.Lee KS,Moon MS.The effect of multilevel laminectomy on the cervical spineof growing cats.An experimental study[J].Spine(Phila Pa 1976),1993,18(3):359-363.
7.Kaptain GJ,Simmons NE,Replogle RE,et al.Incidence and outcome of kyphotic deformity following laminectomy for cervical spondylotic myelopathy[J].J Neurosurg,2000,93(2 suppl):199-204.
8.Fields MJ,Hoshijima K,Feng AH,et al.A biomechanical,radiologic,and clinicalcomparison of outcome after multilevelcervical laminectomy or laminoplasty in the rabbit[J].Spine(Phila Pa 1976),2000,25(22):2925-2931.
9.Kurokawa R,Kim P.Cervical laminoplasty:the history and the future[J].Neurol Med Chir(Tokyo),2015,55(7):529-539.
10.Baisden J,Voo LM,Cusick JF,et al.Evaluation of cervical laminectomy and laminoplasty:a longitudinal study in the goat model[J].Spine(Phila Pa 1976),1999,24(13):1283-289.
11.方加虎.颈椎后凸畸形动物模型构建及其相关研究[D].上海:中国人民解放军海军军医大学,2008,1-142.
12.Kong DC,Zheng TS,Fang JH,et al.Apoptosis of endplate chondrocytes in post-laminectomy cervical kyphotic deformity.An in vivo animal model in sheep[J].Eur Spine J,2013,22(7):1576-1582.
13.Harrison DE,Harrison DD,Cailliet R,et al.Cobb method or Harrison posterior tangent method:which to choose for lateral cervical radiographic analysis[J].Spine(Phila Pa 1976),2000,25(16):2072-2078.
14.Zhang M,Zheng TS,Fang JH,et al.Sustained static stressinduced hondrocyte apoptosis in the rat cervical vertebral growth plate and its signal transduction mechanisms[J].Eur JOrthop Surg Traumatol,2014,24(Suppl 1):299-304.
15.Kong DS,Zheng TS,Fang JH,et al.Static mechanical stress induces apoptosis in rat endplate chondrocytes through MAPK and mitochondria-dependent caspa-se activation signaling pathways[J].PloS one,2013,8:e69403.
16.Eisele PH,Allen CE.Design and use of a protective jacket to prevent self-inflicted injury following cervical laminoplasty in the goat(Capra hircus)[J].Contemp Top Lab Anim Sci,2001,40(2):40-44.
17.Shimizu K,Nakamura M,Nishikawa YJ,et al.Spinal kyphosis causes demyelination and neuronalspine loss in the spinal cord[J].Spine,2005,30(21):2388-2392.
18.刘洋,袁文.颈椎后凸畸形的研究进展[J].中国脊柱脊髓杂志,2007,17(11):873-875.
19.Meziat-Filho N,Ferreira AS,Nogueira LAC,et al."Textneck":an epidemic of the moder-nera of cell phones[J].Spine J,2018,18(4):714-715.
20.Shen XL,Tian Y,Zhou XH,et al.A radiographic analysis of cervical sagittal alignment in adolescent idiopathic cervical kyphosis[J].Clin Spine Surg,2017,30(5):E560-E566.
21.Iwasaki M,Yamamoto T,Miyauchi A,et al.Cervical kyphosis predictive factors for progression of kyphosis and myelopathy[J].Spine(Phila Pa 1976),2002,27(13):1419-1425.
22.沈晓龙,田野,东人,等.青少年特发性颈椎后凸畸形的影像学特征及其临床指导意义[J].中国脊柱脊髓杂志,2011,21(9):745-749.
23.余家阔,吴毅文,戴先进,等.颈椎病生物力学发病机制实验研究[J].安徽医科大学学报,1990,25(1):47-51.
24.施杞,郝永强,彭宝淦,等.动静力平衡失调与颈椎病动物模型的实验研究[J].上海中医药大学学报,1999,13(1):55-59.
25.熊勇,彭锐,邹季.无创兔颈椎间盘退变动物模型的建立及MRI观察[J].中华中医药学刊,2008,26(12):2686-2687.
26.张欣,李殿宁,李开平,等.无创兔颈型颈椎病动物模型的建立[J].中华中医药学刊,2015,33(4):913-916.
27.陈立君,王永春,孙喜庆,等.通过重复+Gz暴露建立实验性家兔颈椎病模型[J].第四军医大学学报,2005,26(20):1911-1914.
28.李翔,方加虎,付鹏.山羊颈椎后凸畸形模型的建立及机制研究[C].第四届长三角地区创伤学术大会暨2014年浙江省创伤学术年会.浙江:2014.252.
29.Wickstrom BM1,Oakley PA,Harrison DE.Non-surgical relief of cervical radic-ulopathy through reduction of forward head posture and restoration of cervical lordosis:a case report[J].J Phys Ther Sci,2017,29(8):1472-1474.
30.Kim SW,Kim TH,Bok DH,et al.Analysis of cervical spine alignment in cur-rently asymptomatic individuals:prevalence of kyphotic posture and its relationship with other spinopelvic parameters[J].Spine,2018,18(5):797-810.
31.Forterre F,Casoni D,Tomek A,et al.Congenital cervical kyphosis in two you-ng sighthounds[J].Vet Comp Orthop Traumatol,2015,28(1):73-78.
32.Giampietro PF,Dunwoodie SL,Kusumi K,et al.Progress in the understanding of the genetic etiology of vertebral segmentation disorders in humans[J].Ann N Y Acad Sci,2009,1151:38-67.
33.乔木,钱邦平,邱勇.遗传综合征型颈椎后凸畸形的分类及治疗[J].中国脊柱脊髓杂志,2007,27(6):553-556.
34.Madera M,Crawford A,Mangano FT.Management of severe cervical kyphosis in a patient with Larsen syndrome:case report[J].J Neurosurg Pediatr,2008,1(4):320-324.
35.Samartzis DD,Herman J,Lubicky JP,et al.Classification of congenitally fused c-ervical patterns in Klippel-Feil patients[J].2006,Spine,31(21):E798-804.
36.Montano AM,Tomatsu S,Gottesman GS,et al.International Morquio:a registry:clinical manifestation and natural course of Morquio A disease[J].J Inherit Metab Dis,2007,30(2):165-174.
37.Piccirilli CB,Chadduck WM.Cervical kyphotic myelopathy in a child with Morquio syndrome[J].Childs NervSyst,1996,12(2):114-116.
38.Giampietro PF,Raggio CL,Blank RD,et al.Clinical,genetic and environment-al factors associated with congenital vertebral malformations[J].Mol Syndromol,2013,4(1-2):94-105.
39.Dickinson AG,Meikle VM.Genetic kyphoscoliosis in mice[J].Lancet,1973,1(7813):1186.
40.Mason RM,Palfrey AJ.Intervertebral disc degeneration in adult mice with here-ditary kyphoscoliosis[J].J Orthop Res,1984,2(4):333-338.
41.Venn G,Mason RM.Changes in mouse intervertebral-disc proteoglycan synthesis with age.Hereditary kyphoscoliosis is associated with elevated synthesis[J].Bioc-hem J,1986,234(2):475-479.
42.Bridges LR,Coulton GR,Howard G,et al.The neuromuscular basis of heredit-ary kyphoscoliosis in the mouse[J].Muscle Nerve,1992,15(2):172-179.
43.Skynner MJ,Gangadharan U,Coulton GR,et al.Genetic mapping of the mou-se neuromuscular mutation kyphoscoliosis[J].Genomics,1995,25(1):207-213.
44.Blanco G,Coulton GR,Biggin A,et al.The kyphoscoliosis(ky)mouse is defi-cient in hypertrophic responses and is caused by a mutation in a novel muscle-specific protein[J].Hum Mol Genet,2001,10(1):9-16.
45.Baker J,Riley G,Romero MR,et al.Identification of a Z-band associated pro-tein complex involving KY,FLNC and IGFN1[J].Exp Cell Res,2010,316(11):1856-1870.
46.Beatham J,Romero R,Townsend SK,et al.Filamin Cinteracts with the musc-ular dystrophy KY protein and is abnormally distributed in mouse KY deficientmuscle fibres[J].Hum Mol Genet,2004,13(22):2863-2874.
47.Hedberg-Oldfors C,Darin N,Olsson Engman M,et al.Anew early-onset neur-omuscular disorder associated with kyphoscoliosis peptidase(KY)deficiency[J].Eur J Hum Genet,2016,24(12):1771-1777.
48.Yogev Y,Perez Y,Noyman I,et al.Progressive hereditary spastic paraplegia ca-used by a homozygous KY mutation[J].Eur J Hum Genet,2017,25(8):966-972.
49.Chiaro JA,Baron MD,Del Alcazar CM,et al.Postnatal progression of bone d-isease in the cervical spines of mucopolysaccharidosis I dogs[J].Bone,2013,55(1):78-83.
50.Haskins M,Casal M,Ellinwood NM,et al.Animal models for mucopolysaccharidoses and their clinical relevance[J].Acta Paediatr Suppl,2002,91(439):88-97.
51.Herati RS,Knox VW,O'Donnell P,et al.Radiographic evaluation of bones andjoints in mucopolysaccharidosis I and VII dogs after neonatal gene therapy[J].Mol Genet Metab,2008,95(3):142-151.
52.Xu HG,Zheng Q,Song JX,et al.Intermittent cyclic mechanical tension promotes endplate cartilage degeneration via canonical Wnt signaling pathway and E-cadherin/β-catenin complex cross-talk[J].Osteoarthritis Cartilage,2016,24(1):158-168.
53.Hiyama A,Sakai D,Risbud MV,et al.Enhancement of intervertebral disc cell senescence by WNT/β-catenin signaling-induced matrix metalloproteinase expression[J].Arthritis Rheum,2010,62(10):3036-3047.
54.Heathfield SK,Le Maitre CL,Hoyland JA.Caveolin-1 expression and stress-induced premature senescence in human intervertebral disc degeneration[J].ArthritisRes Ther,2008,10(4):R87.
55.Wang F,Cai F,Shi R,et al.Aging and age related stresses:a senescence mec-hanism of intervertebral disc degeneration[J].Osteoarthritis Cartilage,2016,24(3):398-408.(收稿日期:2018-06-09修回日期:2018-11-27)
2.Ailon T,Smith JS,Shaffrey CI,et al.Outcomes of operative treatment for adultcervical deformity:a prospective multicenter assessment with 1-year follow-up[J].Neurosurgery,2018,83(5):1031-1039.
3.Cuéllar JM,Lanman TH."Text neck":an epidemic of the moder-nera of cell phones?[J].Spine J,2017,17(6):901-902.
4.Smith JS,Klineberg E,Shaffrey CI,et al.Assessment of surgical treatmentstrategies for moderate to severe cervical spinal deformity reveals marked variatio-nin approaches,osteotomies,and fusion levels[J].World Neurosurg,2016,91:228-237.
5.贾连顺.浅谈颈椎后凸畸形基本概念与诊断学基础[J].脊柱外科杂志,2010,8(2):126-128.
6.Lee KS,Moon MS.The effect of multilevel laminectomy on the cervical spineof growing cats.An experimental study[J].Spine(Phila Pa 1976),1993,18(3):359-363.
7.Kaptain GJ,Simmons NE,Replogle RE,et al.Incidence and outcome of kyphotic deformity following laminectomy for cervical spondylotic myelopathy[J].J Neurosurg,2000,93(2 suppl):199-204.
8.Fields MJ,Hoshijima K,Feng AH,et al.A biomechanical,radiologic,and clinicalcomparison of outcome after multilevelcervical laminectomy or laminoplasty in the rabbit[J].Spine(Phila Pa 1976),2000,25(22):2925-2931.
9.Kurokawa R,Kim P.Cervical laminoplasty:the history and the future[J].Neurol Med Chir(Tokyo),2015,55(7):529-539.
10.Baisden J,Voo LM,Cusick JF,et al.Evaluation of cervical laminectomy and laminoplasty:a longitudinal study in the goat model[J].Spine(Phila Pa 1976),1999,24(13):1283-289.
11.方加虎.颈椎后凸畸形动物模型构建及其相关研究[D].上海:中国人民解放军海军军医大学,2008,1-142.
12.Kong DC,Zheng TS,Fang JH,et al.Apoptosis of endplate chondrocytes in post-laminectomy cervical kyphotic deformity.An in vivo animal model in sheep[J].Eur Spine J,2013,22(7):1576-1582.
13.Harrison DE,Harrison DD,Cailliet R,et al.Cobb method or Harrison posterior tangent method:which to choose for lateral cervical radiographic analysis[J].Spine(Phila Pa 1976),2000,25(16):2072-2078.
14.Zhang M,Zheng TS,Fang JH,et al.Sustained static stressinduced hondrocyte apoptosis in the rat cervical vertebral growth plate and its signal transduction mechanisms[J].Eur JOrthop Surg Traumatol,2014,24(Suppl 1):299-304.
15.Kong DS,Zheng TS,Fang JH,et al.Static mechanical stress induces apoptosis in rat endplate chondrocytes through MAPK and mitochondria-dependent caspa-se activation signaling pathways[J].PloS one,2013,8:e69403.
16.Eisele PH,Allen CE.Design and use of a protective jacket to prevent self-inflicted injury following cervical laminoplasty in the goat(Capra hircus)[J].Contemp Top Lab Anim Sci,2001,40(2):40-44.
17.Shimizu K,Nakamura M,Nishikawa YJ,et al.Spinal kyphosis causes demyelination and neuronalspine loss in the spinal cord[J].Spine,2005,30(21):2388-2392.
18.刘洋,袁文.颈椎后凸畸形的研究进展[J].中国脊柱脊髓杂志,2007,17(11):873-875.
19.Meziat-Filho N,Ferreira AS,Nogueira LAC,et al."Textneck":an epidemic of the moder-nera of cell phones[J].Spine J,2018,18(4):714-715.
20.Shen XL,Tian Y,Zhou XH,et al.A radiographic analysis of cervical sagittal alignment in adolescent idiopathic cervical kyphosis[J].Clin Spine Surg,2017,30(5):E560-E566.
21.Iwasaki M,Yamamoto T,Miyauchi A,et al.Cervical kyphosis predictive factors for progression of kyphosis and myelopathy[J].Spine(Phila Pa 1976),2002,27(13):1419-1425.
22.沈晓龙,田野,东人,等.青少年特发性颈椎后凸畸形的影像学特征及其临床指导意义[J].中国脊柱脊髓杂志,2011,21(9):745-749.
23.余家阔,吴毅文,戴先进,等.颈椎病生物力学发病机制实验研究[J].安徽医科大学学报,1990,25(1):47-51.
24.施杞,郝永强,彭宝淦,等.动静力平衡失调与颈椎病动物模型的实验研究[J].上海中医药大学学报,1999,13(1):55-59.
25.熊勇,彭锐,邹季.无创兔颈椎间盘退变动物模型的建立及MRI观察[J].中华中医药学刊,2008,26(12):2686-2687.
26.张欣,李殿宁,李开平,等.无创兔颈型颈椎病动物模型的建立[J].中华中医药学刊,2015,33(4):913-916.
27.陈立君,王永春,孙喜庆,等.通过重复+Gz暴露建立实验性家兔颈椎病模型[J].第四军医大学学报,2005,26(20):1911-1914.
28.李翔,方加虎,付鹏.山羊颈椎后凸畸形模型的建立及机制研究[C].第四届长三角地区创伤学术大会暨2014年浙江省创伤学术年会.浙江:2014.252.
29.Wickstrom BM1,Oakley PA,Harrison DE.Non-surgical relief of cervical radic-ulopathy through reduction of forward head posture and restoration of cervical lordosis:a case report[J].J Phys Ther Sci,2017,29(8):1472-1474.
30.Kim SW,Kim TH,Bok DH,et al.Analysis of cervical spine alignment in cur-rently asymptomatic individuals:prevalence of kyphotic posture and its relationship with other spinopelvic parameters[J].Spine,2018,18(5):797-810.
31.Forterre F,Casoni D,Tomek A,et al.Congenital cervical kyphosis in two you-ng sighthounds[J].Vet Comp Orthop Traumatol,2015,28(1):73-78.
32.Giampietro PF,Dunwoodie SL,Kusumi K,et al.Progress in the understanding of the genetic etiology of vertebral segmentation disorders in humans[J].Ann N Y Acad Sci,2009,1151:38-67.
33.乔木,钱邦平,邱勇.遗传综合征型颈椎后凸畸形的分类及治疗[J].中国脊柱脊髓杂志,2007,27(6):553-556.
34.Madera M,Crawford A,Mangano FT.Management of severe cervical kyphosis in a patient with Larsen syndrome:case report[J].J Neurosurg Pediatr,2008,1(4):320-324.
35.Samartzis DD,Herman J,Lubicky JP,et al.Classification of congenitally fused c-ervical patterns in Klippel-Feil patients[J].2006,Spine,31(21):E798-804.
36.Montano AM,Tomatsu S,Gottesman GS,et al.International Morquio:a registry:clinical manifestation and natural course of Morquio A disease[J].J Inherit Metab Dis,2007,30(2):165-174.
37.Piccirilli CB,Chadduck WM.Cervical kyphotic myelopathy in a child with Morquio syndrome[J].Childs NervSyst,1996,12(2):114-116.
38.Giampietro PF,Raggio CL,Blank RD,et al.Clinical,genetic and environment-al factors associated with congenital vertebral malformations[J].Mol Syndromol,2013,4(1-2):94-105.
39.Dickinson AG,Meikle VM.Genetic kyphoscoliosis in mice[J].Lancet,1973,1(7813):1186.
40.Mason RM,Palfrey AJ.Intervertebral disc degeneration in adult mice with here-ditary kyphoscoliosis[J].J Orthop Res,1984,2(4):333-338.
41.Venn G,Mason RM.Changes in mouse intervertebral-disc proteoglycan synthesis with age.Hereditary kyphoscoliosis is associated with elevated synthesis[J].Bioc-hem J,1986,234(2):475-479.
42.Bridges LR,Coulton GR,Howard G,et al.The neuromuscular basis of heredit-ary kyphoscoliosis in the mouse[J].Muscle Nerve,1992,15(2):172-179.
43.Skynner MJ,Gangadharan U,Coulton GR,et al.Genetic mapping of the mou-se neuromuscular mutation kyphoscoliosis[J].Genomics,1995,25(1):207-213.
44.Blanco G,Coulton GR,Biggin A,et al.The kyphoscoliosis(ky)mouse is defi-cient in hypertrophic responses and is caused by a mutation in a novel muscle-specific protein[J].Hum Mol Genet,2001,10(1):9-16.
45.Baker J,Riley G,Romero MR,et al.Identification of a Z-band associated pro-tein complex involving KY,FLNC and IGFN1[J].Exp Cell Res,2010,316(11):1856-1870.
46.Beatham J,Romero R,Townsend SK,et al.Filamin Cinteracts with the musc-ular dystrophy KY protein and is abnormally distributed in mouse KY deficientmuscle fibres[J].Hum Mol Genet,2004,13(22):2863-2874.
47.Hedberg-Oldfors C,Darin N,Olsson Engman M,et al.Anew early-onset neur-omuscular disorder associated with kyphoscoliosis peptidase(KY)deficiency[J].Eur J Hum Genet,2016,24(12):1771-1777.
48.Yogev Y,Perez Y,Noyman I,et al.Progressive hereditary spastic paraplegia ca-used by a homozygous KY mutation[J].Eur J Hum Genet,2017,25(8):966-972.
49.Chiaro JA,Baron MD,Del Alcazar CM,et al.Postnatal progression of bone d-isease in the cervical spines of mucopolysaccharidosis I dogs[J].Bone,2013,55(1):78-83.
50.Haskins M,Casal M,Ellinwood NM,et al.Animal models for mucopolysaccharidoses and their clinical relevance[J].Acta Paediatr Suppl,2002,91(439):88-97.
51.Herati RS,Knox VW,O'Donnell P,et al.Radiographic evaluation of bones andjoints in mucopolysaccharidosis I and VII dogs after neonatal gene therapy[J].Mol Genet Metab,2008,95(3):142-151.
52.Xu HG,Zheng Q,Song JX,et al.Intermittent cyclic mechanical tension promotes endplate cartilage degeneration via canonical Wnt signaling pathway and E-cadherin/β-catenin complex cross-talk[J].Osteoarthritis Cartilage,2016,24(1):158-168.
53.Hiyama A,Sakai D,Risbud MV,et al.Enhancement of intervertebral disc cell senescence by WNT/β-catenin signaling-induced matrix metalloproteinase expression[J].Arthritis Rheum,2010,62(10):3036-3047.
54.Heathfield SK,Le Maitre CL,Hoyland JA.Caveolin-1 expression and stress-induced premature senescence in human intervertebral disc degeneration[J].ArthritisRes Ther,2008,10(4):R87.
55.Wang F,Cai F,Shi R,et al.Aging and age related stresses:a senescence mec-hanism of intervertebral disc degeneration[J].Osteoarthritis Cartilage,2016,24(3):398-408.(收稿日期:2018-06-09修回日期:2018-11-27)