夫妻共同治疗对幽门螺杆菌根除率及复发率的影响
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摘要
目的观察夫妻双方共同治疗比单方治疗对幽门螺杆菌根除率及复发率的影响。方法选择2016年1月～2017年9月在我院经~(14)C或~(13)C尿素呼气试验确诊为均感染了幽门螺杆菌的120对夫妻,选取夫妻一方作为研究对象,随机分为试验组60例及对照组60例,试验组夫妻双方均进行幽门螺杆菌根除治疗,而对照组仅夫妻一方进行根除治疗,比较两组患者根除率的差别。随后随访1年,比较两组已根除患者复发率的差异。结果试验组幽门螺杆菌的根除率为88.3%,对照组的根除率为73.3%,两者差异有统计意义(P<0.05)。1年内,试验组幽门螺旋的复发率为2.43%,对照组的复发率为15.15%,两者差异有统计意义(P<0.05)。结论夫妻共同治疗能够提高幽门螺杆菌的根除率及减少复发率。
Objective To observe the effect of co-treatment of couples on eradication rate and recurrence rate of helicobacter pylori compared with unilateral treatment of couples. Methods In 120 couples who were diagnosed as helicobacter pylori infection by ~(14)C or ~(13)C urea breath tests in our hospital from January 2016 to September 2017,one of the couples were selected as research objects.They were randomly divided into the experimental group and the control group,with 60 cases in each group.Both husbands and wives were treated with helicobacter pylori eradication in the experimental group while one of those couples were treated with helicobacter pylori eradication in the control group.Differences in eradication rates of patients were compared between two groups.The patients were followed up for 1 year and the difference in recurrence rate between the two groups was compared. Results The eradication rate of helicobacter pylori of the experimental group was 88.3%,and that of the control group was 73.3%.There were significant differences between the two groups(P < 0.05).Within one year,the recurrence rate of helicobacter pylori of the experimental group was 2.43%,and that of the control group was 15.15%.There were significant differences between the two groups(P < 0.05). Conclusion Co-treatment of couples can improve the eradication rate of helicobacter pylori and reduce the recurrence rate.
Objective To observe the effect of co-treatment of couples on eradication rate and recurrence rate of helicobacter pylori compared with unilateral treatment of couples. Methods In 120 couples who were diagnosed as helicobacter pylori infection by ~(14)C or ~(13)C urea breath tests in our hospital from January 2016 to September 2017,one of the couples were selected as research objects.They were randomly divided into the experimental group and the control group,with 60 cases in each group.Both husbands and wives were treated with helicobacter pylori eradication in the experimental group while one of those couples were treated with helicobacter pylori eradication in the control group.Differences in eradication rates of patients were compared between two groups.The patients were followed up for 1 year and the difference in recurrence rate between the two groups was compared. Results The eradication rate of helicobacter pylori of the experimental group was 88.3%,and that of the control group was 73.3%.There were significant differences between the two groups(P < 0.05).Within one year,the recurrence rate of helicobacter pylori of the experimental group was 2.43%,and that of the control group was 15.15%.There were significant differences between the two groups(P < 0.05). Conclusion Co-treatment of couples can improve the eradication rate of helicobacter pylori and reduce the recurrence rate.
引文
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[14]韩一凡,于新娟,王莉莉,等.中国幽门螺杆菌耐药情况研究[J].胃肠病学和肝病学杂志,2017,6(26):664-668.
[15]中华医学会消化病学分会幽门螺杆菌和消化性溃疡学组,全国幽门螺杆菌研究协作组.2012第五次全国幽门螺旋杆菌感染处理共识报告[J].中国实用内科杂志,2017,6(37):509-524.
[16]杨爱峰.幽门螺旋杆菌感染患者与家庭成员共同治疗的疗效[J].四川生理科学杂志,2017,39(1):28-29.
[17]蒋承霖,蔡奇志,毛文灏,等.共同治疗策略对根除幽门螺杆菌的影响[J].临床消化病杂志,2014,8(26):203-205.
[2]陈鸿程,杨兵.幽门螺杆菌感染的流行病学研究进展[J].临床医药实践,2014,23(12):942-945.
[3]Malfertheiner P,Megraud FO,Morain CA,et al.Management of Helicobacter pylori infection-the MaastrichtⅣ/Florence sensus Report[J].Gut,2012,61:646-664.
[4]熊红兵,吴兴明,肖然,等.胃癌和胃幽门螺旋杆菌的相关性研究分析[J].中国医药科学,2017,7(17):217-219,226.
[5]Zhou L,Zhang J,Song Z,et al.Tailored versus triple plus bismuth or concomitant therapy as initial Helicobacter pylori treatment:a randomized trial[J].Helicobacter,2016,21(2):91-99.
[6]张建中.中国幽门螺杆菌治疗低根除率现状及应对策略[J].胃肠病学和肝病学杂志,2017,6(26):637-639.
[7]O’Connor A,Vaira D,Gisbert JP,et al.Treatment of Helicobacter pylori Infection 2014[J].Helicobacter,2014,Suppl(1):38-45.
[8]沈晓慧,陶竹,王孟春.幽门螺杆菌感染的个体化治疗[J].中国实用内科杂志,2015,12(35):1041-1043.
[9]Eusebi LH,Zagari RM,Bazzoli F.Epidemiology of Helicobacter pylori infection[J].Helicobacter,2014,19:1-5.
[10]谭晓林,陈明,等.14C-UBT检测具有上消化道症状幽门螺杆菌感染及家庭聚集性的分析[J].现代消化及介入诊疗,2014,1(19):21-24.
[11]Fujimoto Y,Furusyo N,Toyoda K,et al.Intrafamilial transmission of Helicobacter pylori among the population of endemic areas in Japan[J].Helicobacter,2007,12(2):170-176.
[12]占义军,邓涛,李红艳,等.配偶间幽门螺杆菌感染的调查研究[J].胃肠病学和肝病学杂志,2011,12(20):1112-1114.
[13]Bruce MG,Bruden DL,Morris JM,et al.Reinfection after successful eradication of Helicobacter pylori in three different populations in Alaska[J].Epidemiol Infect,2015,143(6):1236-1246.
[14]谭淑红,郝庆,李岩.成人幽门螺杆菌根除后复发的研究进展[J].中国实用内科杂志,2017,9(37):852-856.
[14]韩一凡,于新娟,王莉莉,等.中国幽门螺杆菌耐药情况研究[J].胃肠病学和肝病学杂志,2017,6(26):664-668.
[15]中华医学会消化病学分会幽门螺杆菌和消化性溃疡学组,全国幽门螺杆菌研究协作组.2012第五次全国幽门螺旋杆菌感染处理共识报告[J].中国实用内科杂志,2017,6(37):509-524.
[16]杨爱峰.幽门螺旋杆菌感染患者与家庭成员共同治疗的疗效[J].四川生理科学杂志,2017,39(1):28-29.
[17]蒋承霖,蔡奇志,毛文灏,等.共同治疗策略对根除幽门螺杆菌的影响[J].临床消化病杂志,2014,8(26):203-205.