血清D-二聚体、肿瘤组织蛋白激酶CK2β对预测宫颈癌手术患者预后的价值分析
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摘要
目的探讨血清D-二聚体、肿瘤组织蛋白激酶CK2β对预测宫颈癌手术患者预后的价值。方法回顾性分析146例宫颈癌手术患者的临床资料,探讨血清D-二聚体、CK2β与宫颈癌手术患者预后的相关性。结果单因素分析显示,血清D-二聚体、CK2β水平是术后3年无复发生存率的危险因素(P<0.05);多因素分析显示,血清D-二聚体、CK2β是影响宫颈癌手术患者预后的独立危险因素(P<0.05)。结论监测血清D-二聚体、CK2β水平可预测宫颈癌手术患者的预后。
Objective To explore the value of serum D-dimer and tumor tissue protein kinase CK2β in predicting the prognosis of surgical patients with cervical cancer. Methods The clinical data of 146 patients with cervical cancer were analyzed retrospectively, and the correlations between the serum D-dimer, CK2β and the prognosis of the patients with cervical cancer surgery were investigated. Results The univariate analysis showed that serum D-dimer and CK2β were risk factors affecting three-year recurrence-free survival rate(P <0.05);Multivariate analysis showed that serum D-dimer and CK2β were independent risk factors affecting the prognosis of patients with cervical cancer surgery(P <0.05). Conclusions The prognosis of patients with cervical cancer surgery can be predicted according to the levels of serum D-dimer and tumor tissue protein kinase CK2β.
Objective To explore the value of serum D-dimer and tumor tissue protein kinase CK2β in predicting the prognosis of surgical patients with cervical cancer. Methods The clinical data of 146 patients with cervical cancer were analyzed retrospectively, and the correlations between the serum D-dimer, CK2β and the prognosis of the patients with cervical cancer surgery were investigated. Results The univariate analysis showed that serum D-dimer and CK2β were risk factors affecting three-year recurrence-free survival rate(P <0.05);Multivariate analysis showed that serum D-dimer and CK2β were independent risk factors affecting the prognosis of patients with cervical cancer surgery(P <0.05). Conclusions The prognosis of patients with cervical cancer surgery can be predicted according to the levels of serum D-dimer and tumor tissue protein kinase CK2β.
引文
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[2]刘春花,普拉提·努尔别克,杨杰.D-二聚体、纤维蛋白原检测在宫颈癌患者中的临床意义[J].广西医学,2016,38(9):1242-1244.
[3]乐杰.妇产科学[M].第7版.北京:人民卫生出版社,2008:263.
[4]陈晓露,张波,吴蓉宜.CK2β、VEGF和p53蛋白表达对宫颈癌患者预后的预测价值研究[J].重庆医学,2016,45(8):1083-1086.
[5]黄影蓓,李翠丽.术前血浆D-二聚体与早期宫颈癌术后复发相关性研究[J].中华肿瘤防治杂志,2017,24(8):566-569.
[6]吴爱兵,黎明春,麦宗炯,等.CK2α通过PI3K/Akt/GSK-3β信号通路调控肺腺癌A549细胞的侵袭及迁移[J].中国肺癌杂志,2017,20(4):233-238.
[7]Li B,Liu J,Feng R,et al.The tumor-immune index is correlated with the prognosis of patients after curative resection for nonsmall cell Lung cancer[J].Medicine(Baltimore),2015,94(48):e2174.
[8]李达,何静.妇科恶性肿瘤患者凝血功能及D-二聚体水平变化及意义[J].中华实用诊断与治疗杂志,2016,30(6):596-597.
[9]Hochscherf J,Lindenblatt D,Steinkrüger M,et al.Development of a high-throughput screening-compatible assay to identify inhibitors of the CK2α/CK2βinteraction[J].Anal Biochem,2015,468:4-14.