逆行撕除翼状胬肉联合角膜缘干细胞连续缝合移植手术的临床分析
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摘要
目的讨论逆行撕除翼状胬肉联合角膜缘干细胞连续缝合移植治疗翼状胬肉的手术疗效。方法 46例69眼行逆行撕除翼状胬肉联合自体角膜缘干细胞连续缝合移植手术,术后评估角膜创面愈合时间和术后的复发率。结果术后4-8d患者的角膜创面修复,术后3-12mo随访,2例复发,复发率为2.9%。结论逆行撕除翼状胬肉联合自体角膜缘干细胞连续缝合移植手术,不仅可以改善美观,而且可一定程度的降低翼状胬肉的复发率,是临床上治疗翼状胬肉的一种可行性方法。
Objective Discuss retrograde to tear in addition to continuous suture pterygium combined with limbal stem cell transplantation for the treatment of pterygium surgery effect. Methods 69 cases of 46 cases to tear in addition to continuous suture pterygium with autologous corneal limbus stem cells transplantation surgery, postoperative evaluation of corneal wound healing time and postoperative recurrence rate. Result With 4-8 days after corneal wound repair, postoperative follow-up 3-12 months, 2 cases of recurrence, the recurrence rate was 2.9%.Conclusion Retrograde to tear in addition to continuous suture pterygium with autologous corneal limbus stem cell transplant, can improve not only beautiful, but also can reduce the recurrence rate of pterygium, to some extent is a feasible method for the clinical treatment of pterygium.
Objective Discuss retrograde to tear in addition to continuous suture pterygium combined with limbal stem cell transplantation for the treatment of pterygium surgery effect. Methods 69 cases of 46 cases to tear in addition to continuous suture pterygium with autologous corneal limbus stem cells transplantation surgery, postoperative evaluation of corneal wound healing time and postoperative recurrence rate. Result With 4-8 days after corneal wound repair, postoperative follow-up 3-12 months, 2 cases of recurrence, the recurrence rate was 2.9%.Conclusion Retrograde to tear in addition to continuous suture pterygium with autologous corneal limbus stem cell transplant, can improve not only beautiful, but also can reduce the recurrence rate of pterygium, to some extent is a feasible method for the clinical treatment of pterygium.
引文
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[5]刘仓仓,徐春丽,何君,等.角膜缘干细胞移植术治疗双侧翼状胬肉的疗效[J].国际眼科杂志,2019,19(3):491-493.DOI:10.3980/j.issn.1672-5123.2019.3.35.
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[11]李静,崔永日.翼状胬肉的逆行撕除法与顺行切除法的疗效对比[J/CD].中华眼科医学杂志(电子版),2015,5(5):259-262.DOI:10.3877/cma.j.issn.2095-2007.2015.05.006.
[12]杨英,蔡岩,李鹏,等.逆行剥离法在翼状胬肉切除联合球结膜瓣移植术中的应用[J].眼科学报,2018,33(4):233-235.DOI:10.3978/j.issn.1000-4432.2018.08.03.
[13]姚春芽.显微手术翼状胬肉切除术中使用不同显微缝线的临床疗效[J].中国实用医药,2018,13(25):75-76.DOI:10.14163/j.cnki.11-5547/r.2018.25.043.
[14]孙红艳,朱江.人纤维蛋白粘合剂联合角膜缘干细胞移植术治疗翼状胬肉[J].国际眼科杂志,2018,18(9):1735-1738.DOI:10.3980/j.issn.1672-5123.2018.9.43.
[15]王秀,杨军,宁玉贤,等.纤维蛋白胶在翼状胬肉手术中应用的研究进展[J].眼科新进展,2016,36(2):186-189.DOI:10.13389/j.cnki.rao.2016.0051.
[16]熊毅,杨森,唐建明.生物羊膜和角膜绷带镜作为辅助材料用于治疗翼状胬肉的临床效果对比分析[J].眼科新进展,2018,38(4):378-381.DOI:10.13389/j.cnki.rao.2018.0088.
[2]Bhandari V,R ao CL,Ganesh S,et al.Visual outcome and efficacy of conjunctival autograft,harvested from the body of pterygium in pterygium excision[J].Clin Ophthalmol,2015,9:2285-2290.DOI:10.2147/OPTH.S93580.eCollection 2015.
[3]RazmjooH,Vaezi MH,Peyman A,Koosha N,et al.The effect of pterygium surgery on wavefront analysi[J].Adv Biomed R es,2014,23(3):196.DOI:10.4103/2277-9175.140677.eCollection 2014.
[4]高琳,艾明.不同浓度丝裂霉素治疗复发性翼状胬肉的比较[J].国际眼科杂志,2015,15(2):359-360.DOI:10.3980/j.issn.1672-5123.2015.2.51.
[5]刘仓仓,徐春丽,何君,等.角膜缘干细胞移植术治疗双侧翼状胬肉的疗效[J].国际眼科杂志,2019,19(3):491-493.DOI:10.3980/j.issn.1672-5123.2019.3.35.
[6]Anguria P,Carmichael T,Ntuli S,et al.Chronic inflammatory cells and damaged limbal cells in pterygium[J].Afr Health Sci 2013,13(3):725-730.DOI:10.4314/ahs.v13i3.29.
[7]Malek I,Zghal I,Chebbi A,et al.Conjunctival limbal autograft versus simple excision with intraoperative mitomycin C in pterygium surgery:a comparative study[J].J Fr Ophtalmol 2013,36(3):230-235.DOI:10.1016/j.jfo.2012.03.017.Epub2012 Dec 10.
[8]聂爱芹,李强,李伟.角膜缘自体结膜移植和羊膜移植治疗原发性翼状胬肉的疗效[J].国际眼科杂志,2018,18(3):581-584.DOI:10.3980/j.issn.1672-5123.2018.3.44.
[9]Janson BJ,Sikder S.Surgical management of pterygium[J].Ocul Surf,2014,12(2):112-119.DOI:10.1016/j.jtos.2014.01.001.Epub 2014 Jan 31.
[10]Liang L,Li W,Ling S,et al.Amniotic membrane extraction solution for ocular chemical burns[J].Clin Experiment Ophthalmol,2009,37(9):855-863.DOI:10.1111/j.1442-9071.2009.02159.x.
[11]李静,崔永日.翼状胬肉的逆行撕除法与顺行切除法的疗效对比[J/CD].中华眼科医学杂志(电子版),2015,5(5):259-262.DOI:10.3877/cma.j.issn.2095-2007.2015.05.006.
[12]杨英,蔡岩,李鹏,等.逆行剥离法在翼状胬肉切除联合球结膜瓣移植术中的应用[J].眼科学报,2018,33(4):233-235.DOI:10.3978/j.issn.1000-4432.2018.08.03.
[13]姚春芽.显微手术翼状胬肉切除术中使用不同显微缝线的临床疗效[J].中国实用医药,2018,13(25):75-76.DOI:10.14163/j.cnki.11-5547/r.2018.25.043.
[14]孙红艳,朱江.人纤维蛋白粘合剂联合角膜缘干细胞移植术治疗翼状胬肉[J].国际眼科杂志,2018,18(9):1735-1738.DOI:10.3980/j.issn.1672-5123.2018.9.43.
[15]王秀,杨军,宁玉贤,等.纤维蛋白胶在翼状胬肉手术中应用的研究进展[J].眼科新进展,2016,36(2):186-189.DOI:10.13389/j.cnki.rao.2016.0051.
[16]熊毅,杨森,唐建明.生物羊膜和角膜绷带镜作为辅助材料用于治疗翼状胬肉的临床效果对比分析[J].眼科新进展,2018,38(4):378-381.DOI:10.13389/j.cnki.rao.2018.0088.