蛋白质结构展示在生物化学教学中的应用
|
摘要
蛋白质结构的研究已成为目前生物学研究的前沿与热点,大量获得的蛋白质结构为基础教学提供了重要的教学素材。通过蛋白质结构的展示,丰富和完善了生物化学课程的知识体系,激发了学生的学习兴趣。本文将蛋白质结构的展示应用到生物化学教学中,以"蛋白质化学"和"酶"章节为例,将概念、知识点与可视的空间结构结合并引入课堂教学,有助于激发学生学习的主动性并提升课堂教学效果。
The study of protein structure has become a frontier and hotspot in current biological research.A large number of protein structures have provided important teaching materials for basic teaching.Through the display of protein structure,the knowledge system of biochemistry curriculum was improved and enriched,and students' interest in learning was inspired.This paper applies the display of protein structure to the teaching of biochemistry.Taking the chapters of "Protein Chemistry" and "Enzymes" as examples,combining the concepts,knowledge points and visual spatial structure into classroom teaching can help inspire students to learn and improve classroom teaching effectiveness.
The study of protein structure has become a frontier and hotspot in current biological research.A large number of protein structures have provided important teaching materials for basic teaching.Through the display of protein structure,the knowledge system of biochemistry curriculum was improved and enriched,and students' interest in learning was inspired.This paper applies the display of protein structure to the teaching of biochemistry.Taking the chapters of "Protein Chemistry" and "Enzymes" as examples,combining the concepts,knowledge points and visual spatial structure into classroom teaching can help inspire students to learn and improve classroom teaching effectiveness.
引文
[1]施媚,李恩,刘俊红,等.生物化学中“糖酵解”的课堂设计与教学体会[J].生物学杂志,2018,35(1):125-126.
[2]Berman H M,Westbrook J,Feng Z,et al.The Protein DataBank[J].Nucleic Acids Research,2000,28(1):235-242.
[3]Guex,N,Peitsch,M C.SWISS-MODEL and the Swiss-Pdb-Viewer:An environment for comparative protein modeling[J].Electrophoresis,1997,(18):2714-2723.
[4]邓海游,贾亚,张阳.蛋白质结构预测[J].物理学报,2016,65(17):178701
[5]Trott O,Olson A J.AutoDock Vina:improving the speed and accuracy of docking with a new scoring function,efficient optimization and multithreading[J].Journal of Computational Chemistry,2009,31(2010):455-461.
[6]张斌,黄伟伟.蛋白质数据库(PD B)在基础生物化学课程教学中的应用[J].高教学刊,2018,(1):71-72.
[7]Nobuyuki S,Yoshitaka U,Tomoko N,et al.Crystal Structuresof the reaction intermediate and its homologue of an extradiol-cleaving catecholic dioxygenase[J].Journal of Molecular Biology,321:621-636.
[2]Berman H M,Westbrook J,Feng Z,et al.The Protein DataBank[J].Nucleic Acids Research,2000,28(1):235-242.
[3]Guex,N,Peitsch,M C.SWISS-MODEL and the Swiss-Pdb-Viewer:An environment for comparative protein modeling[J].Electrophoresis,1997,(18):2714-2723.
[4]邓海游,贾亚,张阳.蛋白质结构预测[J].物理学报,2016,65(17):178701
[5]Trott O,Olson A J.AutoDock Vina:improving the speed and accuracy of docking with a new scoring function,efficient optimization and multithreading[J].Journal of Computational Chemistry,2009,31(2010):455-461.
[6]张斌,黄伟伟.蛋白质数据库(PD B)在基础生物化学课程教学中的应用[J].高教学刊,2018,(1):71-72.
[7]Nobuyuki S,Yoshitaka U,Tomoko N,et al.Crystal Structuresof the reaction intermediate and its homologue of an extradiol-cleaving catecholic dioxygenase[J].Journal of Molecular Biology,321:621-636.