平均血小板体积/血小板计数、载脂蛋白B/A1与高血压患者动态动脉硬化指数的相关性
摘要
目的探讨平均血小板体积/血小板计数(MPV/PLT)、载脂蛋白B/A1(ApoB/A1)与高血压患者动态动脉硬化指数(AASI)的相关性。方法选取2015年5月至2018年6月期间收治的高血压患者228例为研究对象,根据AASI中位数的大小分为A组(24 h AASI<0.53,n=111)和B组(24 h AASI≥0.53,n=117)。比较各组间基本资料及MPV/PLT、ApoB/A1水平,并进行Pearson相关分析与Logistic回归分析。结果 A组的年龄、病程、收缩压、总胆固醇、低密度脂蛋白胆固醇(LDL-C)、AASI、MPV/PLT、ApoB/A1低于B组,舒张压高于B组(均P<0.05)。高MPV/PLT高血压患者AASI高于低MPV/PLT者(0.65±0.06比0.48±0.04,P<0.05)。高ApoB/A1高血压患者AASI高于低ApoB/A1者(0.62±0.07比0.50±0.06,P<0.05)。Pearson相关性分析显示,高血压患者年龄、病程、收缩压、总胆固醇、LDL-C、MPV/PLT、ApoB/A1与AASI相关(r=0.621、0.704、0.725、0.675、0.653、0.677、0.716,均P<0.05)。Logistic多元逐步回归分析显示,年龄、病程、收缩压、总胆固醇、LDL-C、MPV/PLT、ApoB/A1是高血压患者AASI的独立危险因素。结论 MPV/PLT、ApoB/A1与高血压患者AASI升高有关。
引文
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[2] 刘艳,曹桂莲,陈爱芳.原发性高血压患者动态动脉硬化指数与颈动脉粥样硬化的相关性[J].中国动脉硬化杂志,2010,18(7):563-565.
[3] 赵兴,郭健伟,刘欢,等.原发性高血压患者红细胞和血小板参数的变化与颈动脉粥样硬化的关系[J].宁夏医科大学学报,2013,35(2):206-208.
[4] Doran B,Guo Y,Xu J,et al.Prognostic value of fasting versus nonfasting low-density lipoprotein chliesterol levels long-term mortality:insight from the national heath and nutrition examination survey Ⅲ(nhanes-Ⅲ)[J].Circulation,2014,130(7):546-553.
[5] 中国高血压防治指南修订委员会.中国高血压防治指南2010[J].中华高血压杂志,2011,19(8):701-743.
[6] Fudge EB,Constantacos C,Fudge JC,et al.Improving detection of hypertension in girls with turner syndrome using ambulatory blood pressure monitoring[J].Horm Res Paediatr,2014,81(1):25-31.
[7] Wang B,Lin L,Zhao C.Related factors of serum uric acid in patients with primary hypertension and hyperhomocysteinemia[J].Ciln Exp Hypertens,2016,38(3):312-316.
[8] 孙艳,杨苏,何燕,等.老年高血压患者动态动脉硬化指数与脉搏波传导速度、脉压指数的相关性[J].昆明医科大学学报,2016,37(2):93-95.
[9] Bastos J,Filipa S,Joana S,et al.The prognostic value of ambulatory arterial stiffness index as a predictor of cardiovascular events in resistant hypertensive patients[J].J Hypertens,2015,33(Suppl 1):e74.
[10] Kapur R,Semple JW.Platelets as immune-sensing cells[J].Blood Adv,2016,1(1):10-14.
[11] Elbasan Z,Gür M,Sahin DY,et al.Mean platelet volume and abnormal left ventricle geometric patterns in patients with untreated essential hypertension[J].Platelets,2013,24(7):521-527.
[12] Catapano AL,Graham I,De Backer G,et al.ESC/EAS guidelines for the management of dyslipidaemias:the task force for the management of dyslipidaemia of the Europe Society of Cardiology (ESC)and the European Atherosclerosis Society(EAS)[J].Eur Heart J,2016,37(39):2999-3058.
[13] Calabresi L,Comaraschi M,Simonelli S,et al.HDL and atherosclerosis:insights from inherited HDL,disorder[J].Bio Chim Biophys Acta,2015,1851(1):13-18.
[14] Shapiro MD,Fazio S.Apolipoprotein B-containing lipoproteins and atherosclerotic cardiovascular disease[J].F1000Res,2017,6:134.
[15] Li G,Zhang Y,Zhu Z,et al.Association between mean platelet volume and hypertension incidence[J].Hypertens Res,2017,40(8):779-784.
[16] 陶萍华,吕晓玲,范芳华,等.体检人群血浆致动脉硬化指数与血清ApoB/ApoA1比值的相关性研究[J].心脑血管病防治,2014,18(3):207-209.
[17] 王静,谷云飞,金军,等.平均血小板体积/血小板计数比值对急性ST段抬高型心肌梗死PCI术后院内心脏不良事件的预测作用[J].中国心血管病研究,2016,14(1):45-48.
[18] Jain J,Lathia T,Gupta OP,et al.Carotid intima-media thickness and apolipoproteins in patients of ischemic stroke in a rural hospital setting in central India:a cross-sectional study[J].J Neurosci Rurla Pract,2012,3(1):21-27.