腹部战创伤动物模型的研究进展
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摘要
战创伤是战场上参战人员受伤的主要类型,不同于单一的致伤因素,其伤情较复杂,感染率较高,预后较差。腹部战创伤在战创伤中占很大的比例,开放性损伤比例较高,多发伤和复合伤较常见,早期致死率及致残率较高,救治难度大,因此建立腹部战创伤动物模型,重现战场环境下伤员的伤情就显得尤为重要。近年来许多专家学者在相关模型的建立方面付出了很多努力,取得了很好的建模效果。
War injury is the main type of trauma on the battlefield. The traumatic condition is complex, the causing factors are diverse, the infection rate is high, and the prognosis is poor. Abdominal war injury occupies a large proportion in the trauma. And the proportion of open abdominal injury, multiple trauma and combined injury is high, leading to high rate of early mortality and disability. It is especially important to establish the animal model of abdominal war injury properly so as to reproduce the injury situation in the battlefield environment. During recent years, the experts and scholars have made great efforts in establishing relevant models and have achieved good modeling results.
War injury is the main type of trauma on the battlefield. The traumatic condition is complex, the causing factors are diverse, the infection rate is high, and the prognosis is poor. Abdominal war injury occupies a large proportion in the trauma. And the proportion of open abdominal injury, multiple trauma and combined injury is high, leading to high rate of early mortality and disability. It is especially important to establish the animal model of abdominal war injury properly so as to reproduce the injury situation in the battlefield environment. During recent years, the experts and scholars have made great efforts in establishing relevant models and have achieved good modeling results.
引文
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[23] 屈纪富,梁华平.炎症调控与脓毒症研究进展[J].创伤外科杂志,2012,14(5):459-463.
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[25] 丁国飞.腹壁战创伤缺损修复固定装置及污染伤口下犬腹壁缺损修复材料的研制[D].北京:解放军总医院军医进修学院,2012.
[26] 王正国,梁华平.战创伤感染与脓毒症防治新策略[J].中华卫生应急电子杂志.2015,(1):1-3.
[27] 陶瑞雨.高原高寒地区腹腔严重感染及腹部外加压治疗腹腔创伤性大出血的实验研究[D].兰州:兰州大学,2017.
[28] 何红艳,赖彦华,磨婷婷,等.间接腹内压监测在基层部队腹部战创伤救治中的应用[J].解放军护理杂志,2016,33(6):44-47.
[2] Horeczko T,Green JP,Panacek EA.Epidemiology of the Systemic Inflammatory Response Syndrome (SIRS) in the emergency department[J].West J Emerg Med,2014,15(3):329-336.
[3] Volpin G,Cohen M,Assaf M,et al.Cytokine levels (IL-4,IL-6,IL-8 and TGFbeta) as potential biomarkers of systemic inflammatory response in trauma patients[J].Int Orthop,2014,38(6):1303-1309.
[4] 陈国庭.腹部创伤后并发症的防治[J].中国普外基础与临床杂志,2015,22(3):260-262.
[5] 朱震宇,黄志强,张爱群,等.腹部多发脏器伤模型的建立及评价[J].解放军医学杂志,2009,34(9):1134-1136.
[6] 刘恩岐.人类疾病动物模型[M].2版.北京:人民卫生出版社,2014:13-14
[7] 刘江伟,张永久,李泽信,等.常温和干热环境下腹部肠管火器伤动物模型的建立[J].创伤外科杂志,2007,9(5):408-410.
[8] 王育红,杨兴东,段蕴铀,等.犬腹部开放伤合并人工海水浸泡的早期综合救治分析[J].中华普通外科杂志,2004,19(6):367-369.
[9] 卢灿荣,黄志强.新型严重肝外伤动物模型的建立及“腹部实质器官包扎绷带”的应用研究[D].北京:中国人民解放军军医进修学院,2007.
[10] 魏泓.医学动物实验技术[M].北京:人民卫生出版社,2016:1059
[11] 林孝文,祁亚峰,张再重,等.腹部枪弹伤合并海水浸泡猪模型的建立[J].中华航海医学与高气压医学杂志,2016,23(4):273-277.
[12] 王鹏飞,毛琦,李幼生,等.严重腹部贯通伤致多发肠管损伤合并“致死三联征”模型的建立[J].解放军医学杂志,2011,36(3):293-296.
[13] 夏印,张再重,黄纯,等.濒海实地腹部战创伤三级救治的动物实验研究[J].中国急救复苏与灾害医学杂志,2016,11(1):36-38.
[14] Reynolds CL,Celio AC,Bridges LC,et al.REBOA for the IVC?Resuscitative balloon occlusion of the inferior vena cava (REBOVC) to abate massive hemorrhage in retrohepatic vena cava injuries[J].J Trauma Acute Care Surg,2017,83(6):1041-1046.
[15] Lallemand MS,Moe DM,McClellan JM,et al.Resuscitative endovascular balloon occlusion of the aorta for major abdominal venous injury in a porcine hemorrhagic shock model[J].J Trauma Acute Care Surg,2017,83(2):230-236.
[16] 杨鹤鸣,李荣,徐迎新.野战腹部创伤非控制性失血性休克的分阶段救治模拟研究[J].解放军医学杂志,2008,33(5):510-513.
[17] Vrettos T,Poimenidi E,Athanasopoulos P,et al.The effect of permissive hypotension in combined traumatic brain injury and blunt abdominal trauma:an experimental study in swines[J].Eur Rev Med Pharmacol Sci,2016,20(4):620-630.
[18] Zentai C,van der Meijden PE,Braunschweig T,et al.Hemostatic therapy using tranexamic acid and coagulation factor concentrates in a model of traumatic liver Injury[J].Anesth Analg,2016,123(1):38-48.
[19] Grottke O,Braunschweig T,Philippen B,et al.A new model for blunt liver injuries in the swine[J].Eur Surg Res,2010,44(2):65-73.
[20] Yao T,Rong J,Liang M,et al.Emergency treatment of splenic injury in a novel mobile minimally invasive interventional shelter following disaster:a feasibility study[J].Scand J Trauma Resusc Emerg Med,2014,22:44.
[21] Zhang Q,Raoof M,Chen Y,et al.Circulating mitochondrial DAMPs cause inflammatory responses to injury[J].Nature,2010,464(7285):104-107.
[22] 付圆.脓毒症发病机制的研究进展[J].中国现代医生,2014,52(11):155-157.
[23] 屈纪富,梁华平.炎症调控与脓毒症研究进展[J].创伤外科杂志,2012,14(5):459-463.
[24] Wehrenpfennig P,Drechsler S,Weixelbaumer KM,et al.Mouse model of posttraumatic abdominal sepsis:survival advantage of females over males does not depend on the cecum size[J].Eur Surg Res,2014,52(1-2):83-89.
[25] 丁国飞.腹壁战创伤缺损修复固定装置及污染伤口下犬腹壁缺损修复材料的研制[D].北京:解放军总医院军医进修学院,2012.
[26] 王正国,梁华平.战创伤感染与脓毒症防治新策略[J].中华卫生应急电子杂志.2015,(1):1-3.
[27] 陶瑞雨.高原高寒地区腹腔严重感染及腹部外加压治疗腹腔创伤性大出血的实验研究[D].兰州:兰州大学,2017.
[28] 何红艳,赖彦华,磨婷婷,等.间接腹内压监测在基层部队腹部战创伤救治中的应用[J].解放军护理杂志,2016,33(6):44-47.