天然黑色素理化性质与功能特性研究进展
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摘要
黑色素是广泛存在于生物体中的一类天然色素,具有许多重要的生理功能。本文从天然黑色素溶解性、光吸收特性、氧化还原特性、金属螯合特性、自由基特性等理化性质以及加固结构、抗辐射、抗氧化、螯合重金属、抗病毒、抗衰老、免疫调节和DNA保护等功能特性方面进行了综述。
Melanin represents a group of natural pigments,which is widely dispersed in the organisms and possesses many important physiological functions. In this paper,some research advances of the natural melanin,including solubility,light absorbance,redox,chelating metal ions,free radical of physicochemical properties and strengthened structures,radiation resisting,antioxidation,chelating heavy metal,antiviral,anti-aging,immune regulation,DNA protection of functional properties were reported.
Melanin represents a group of natural pigments,which is widely dispersed in the organisms and possesses many important physiological functions. In this paper,some research advances of the natural melanin,including solubility,light absorbance,redox,chelating metal ions,free radical of physicochemical properties and strengthened structures,radiation resisting,antioxidation,chelating heavy metal,antiviral,anti-aging,immune regulation,DNA protection of functional properties were reported.
引文
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[2]Chen SR,Jiang B,Zheng JX,et al.Isolation and characterization of natural melanin derived from silky fowl(Gallus gallus domesticus Brisson)[J].Food Chemistry,2008,111:745-749.
[3]Tu Y,Sun Y,Tian Y,et al.Physicochemical characterisation and antioxidant activity of melanin from the muscles of Taihe Black-bone silky fowl(Gallus gallus domesticus Brisson)[J].Food Chemistry,2009,114:1345-1350.
[4]姚增玉,赵忠,李科友,等.山杏种皮黑色素理化性质研究[J].食品与发酵工业,2007,33(9):37-40.
[5]李琦,侯丽华,刘鑫,等.黑木耳黑色素鉴定及提取工艺优化[J].食品科学,2010,31(16):87-92.
[6]徐磊,钱振明,孙继波,等.短梗霉黑色素的分离纯化及结构的初步分析[J].氨基酸和生物资源,2009,31(2):9-13.
[7]Aghajanyan AE,Hambardzumyan AA,Hovsepyan AS,et al.Isolation,purification and physicochemical characterization of water-soluble Bacillus thuringiensis melanin[J].Pigment Cell Research,2005,18(2):130-135.
[8]雷敏.鱿鱼墨黑色素及黑色素铁生物活性的研究[D].青岛:中国海洋大学,2008.
[9]Plonka PM,Grabacka M.Melanin synthesis in microorganisms-biotechnological and medical aspects[J].Acta Biochimica Polonica,2006,53(3):429-443.
[10]Buszman E,Pilawa B,Zdybel M,et al.EPR examination of Zn2+and Cu2+binding by pigmented soil fungi Cladosporium cladosporioides[J].Science of the Total Environment,2006,363:195-205.
[11]Barbara B.On the structure of human hair melanins from an infrared spectroscopy analysis of their interactions with Cu2+ions[J].Spectrochimica Acta Part A,2001,57:2525-2533.
[12]Meredith P,Sarna T.The physical and chemical properties of eumelanin[J].Pigment Cell Research,2006,19(6):572-594.
[13]Vincensi M R,d’Ischia M,Napolitano A,et al.Phaeomelanin versus eumelanin as a chemical indicator of ultraviolet sensitivity in fair-skinned subjects at high risk for melanoma:a pilot study[J].Melanoma Research,1998,8:53-58.
[14]Henson JM,Butler MJ,Day AW.The Dark Side of the Mycelium:Melanins of Phytopathogenic Fungi[J].Annual Review of Phytopathology.1999,37:447-471.
[15]Angel L,Rosas AC.Melanization decreases the susceptibility of Cryptococcus neoformans to enzymatic degradation[J].Mycopathologia,2000,151:53-56.
[16]Kollias N,Sayre RM,Zeise L,et al.Photoprotection by melanin[J].Journal of Photochemistry and Photobiology B,Biology,1991(9):135-160.
[17]Menter JM.Photoproteetion of mammalian acid-soluble collagen by cuttlefish sepia melanin in vitro[J].Ameriean Society for Photobiology,1998,68:532-537.
[18]Geng J,Yu SB,Wan X,et al.Protective action of bacterial melanin against DNA damage in full UV spectrums by a sensitive plasmid-based noncellular system[J].Journal of Biochemical and Biophysical Methods,2008,70:1151-1155.
[19]Wu Y,Shan L,Yang S,et V,Yang S.,Hong M,et al.Identification and antioxidant activity of melanin isolated from Hypoxylon archeri,a companion fungus of Tremella fuciformis[J].Journal of Basic Microbiology,2008,48:217-221.
[20]Liu JH,Tian YG,Wang Y,et al.Characterization and in vitro antioxidation of papain hydrolysate from black-bone silky fowl(Gallus gallus domesticus Brisson)muscle and its fractions[J].Food Research International,2011,44:133-138.
[21]涂勇刚,孙亚真,田颖刚,等.泰和乌骨鸡黑色素的体外抗氧化作用[J].食品与生物技术学报,2009,28(2):145-149.
[22]张莲姬.泥鳅鱼黑色素抗氧化作用用[J].食品研究与开发,2010,31(8):11-14.
[23]Geoffrey MG,Louise R.Biosorption of copper by fungal melanin[J].Applied Microbiology Biotechnology,1988,29:610-617.
[24]姚增玉,李科友,赵忠,等.山杏种皮黑色素与Cu2+和Zn2+络合性质的研究[J].西北农林科技大学学报:自然科学版,2008,36(3):197-202.
[25]Manning JT,Bundred PE,Henzi P.Melanin and HIV in sub-Saharan Africa[J].Journal of Theoretical Biology,2003,223:131-133.
[26]郑从义,屈三甫,彭方,等.细菌转化黑色素的抗流感病毒作用[J].氨基酸和生物资源,1999,21(1):30-33.
[27]张晓玲,杨桥,代俊,等.黑色素及谷胱甘肽通过抑制NF-κB途径的激活可有效抑制H5N1禽流感病毒感染[J].中国生物化学与分子生物学报,2009,25(4):364-372.
[28]徐幸莲,庄苏,陈伯祥.乌骨鸡黑色素对延缓果蝇衰老的作用[J].南京农业大学学报,1999,22(2):105-108.
[29]Sava VM,Galkin BN,Hong MY,et al.A novel melanin-like pigment derived from black tea leaves with immuno-stimulating activity[J].Food Research International,2001,34:337-343.
[30]Sava VM,Hung YC,Golkinc BN,et al.Protective activity of melanin-like pigment derived from tea on Drosophila melasnogaster against the toxic effects of benzidine[J].Food Research International,2002,35:619-626.
[31]Shcherba V,Babitskaya V,Kurchenko V,et al.Antioxidant properties of fungal melanin pigments[J].Applied Biochemistry and Microbiology,2000,36(5):491-495.
[2]Chen SR,Jiang B,Zheng JX,et al.Isolation and characterization of natural melanin derived from silky fowl(Gallus gallus domesticus Brisson)[J].Food Chemistry,2008,111:745-749.
[3]Tu Y,Sun Y,Tian Y,et al.Physicochemical characterisation and antioxidant activity of melanin from the muscles of Taihe Black-bone silky fowl(Gallus gallus domesticus Brisson)[J].Food Chemistry,2009,114:1345-1350.
[4]姚增玉,赵忠,李科友,等.山杏种皮黑色素理化性质研究[J].食品与发酵工业,2007,33(9):37-40.
[5]李琦,侯丽华,刘鑫,等.黑木耳黑色素鉴定及提取工艺优化[J].食品科学,2010,31(16):87-92.
[6]徐磊,钱振明,孙继波,等.短梗霉黑色素的分离纯化及结构的初步分析[J].氨基酸和生物资源,2009,31(2):9-13.
[7]Aghajanyan AE,Hambardzumyan AA,Hovsepyan AS,et al.Isolation,purification and physicochemical characterization of water-soluble Bacillus thuringiensis melanin[J].Pigment Cell Research,2005,18(2):130-135.
[8]雷敏.鱿鱼墨黑色素及黑色素铁生物活性的研究[D].青岛:中国海洋大学,2008.
[9]Plonka PM,Grabacka M.Melanin synthesis in microorganisms-biotechnological and medical aspects[J].Acta Biochimica Polonica,2006,53(3):429-443.
[10]Buszman E,Pilawa B,Zdybel M,et al.EPR examination of Zn2+and Cu2+binding by pigmented soil fungi Cladosporium cladosporioides[J].Science of the Total Environment,2006,363:195-205.
[11]Barbara B.On the structure of human hair melanins from an infrared spectroscopy analysis of their interactions with Cu2+ions[J].Spectrochimica Acta Part A,2001,57:2525-2533.
[12]Meredith P,Sarna T.The physical and chemical properties of eumelanin[J].Pigment Cell Research,2006,19(6):572-594.
[13]Vincensi M R,d’Ischia M,Napolitano A,et al.Phaeomelanin versus eumelanin as a chemical indicator of ultraviolet sensitivity in fair-skinned subjects at high risk for melanoma:a pilot study[J].Melanoma Research,1998,8:53-58.
[14]Henson JM,Butler MJ,Day AW.The Dark Side of the Mycelium:Melanins of Phytopathogenic Fungi[J].Annual Review of Phytopathology.1999,37:447-471.
[15]Angel L,Rosas AC.Melanization decreases the susceptibility of Cryptococcus neoformans to enzymatic degradation[J].Mycopathologia,2000,151:53-56.
[16]Kollias N,Sayre RM,Zeise L,et al.Photoprotection by melanin[J].Journal of Photochemistry and Photobiology B,Biology,1991(9):135-160.
[17]Menter JM.Photoproteetion of mammalian acid-soluble collagen by cuttlefish sepia melanin in vitro[J].Ameriean Society for Photobiology,1998,68:532-537.
[18]Geng J,Yu SB,Wan X,et al.Protective action of bacterial melanin against DNA damage in full UV spectrums by a sensitive plasmid-based noncellular system[J].Journal of Biochemical and Biophysical Methods,2008,70:1151-1155.
[19]Wu Y,Shan L,Yang S,et V,Yang S.,Hong M,et al.Identification and antioxidant activity of melanin isolated from Hypoxylon archeri,a companion fungus of Tremella fuciformis[J].Journal of Basic Microbiology,2008,48:217-221.
[20]Liu JH,Tian YG,Wang Y,et al.Characterization and in vitro antioxidation of papain hydrolysate from black-bone silky fowl(Gallus gallus domesticus Brisson)muscle and its fractions[J].Food Research International,2011,44:133-138.
[21]涂勇刚,孙亚真,田颖刚,等.泰和乌骨鸡黑色素的体外抗氧化作用[J].食品与生物技术学报,2009,28(2):145-149.
[22]张莲姬.泥鳅鱼黑色素抗氧化作用用[J].食品研究与开发,2010,31(8):11-14.
[23]Geoffrey MG,Louise R.Biosorption of copper by fungal melanin[J].Applied Microbiology Biotechnology,1988,29:610-617.
[24]姚增玉,李科友,赵忠,等.山杏种皮黑色素与Cu2+和Zn2+络合性质的研究[J].西北农林科技大学学报:自然科学版,2008,36(3):197-202.
[25]Manning JT,Bundred PE,Henzi P.Melanin and HIV in sub-Saharan Africa[J].Journal of Theoretical Biology,2003,223:131-133.
[26]郑从义,屈三甫,彭方,等.细菌转化黑色素的抗流感病毒作用[J].氨基酸和生物资源,1999,21(1):30-33.
[27]张晓玲,杨桥,代俊,等.黑色素及谷胱甘肽通过抑制NF-κB途径的激活可有效抑制H5N1禽流感病毒感染[J].中国生物化学与分子生物学报,2009,25(4):364-372.
[28]徐幸莲,庄苏,陈伯祥.乌骨鸡黑色素对延缓果蝇衰老的作用[J].南京农业大学学报,1999,22(2):105-108.
[29]Sava VM,Galkin BN,Hong MY,et al.A novel melanin-like pigment derived from black tea leaves with immuno-stimulating activity[J].Food Research International,2001,34:337-343.
[30]Sava VM,Hung YC,Golkinc BN,et al.Protective activity of melanin-like pigment derived from tea on Drosophila melasnogaster against the toxic effects of benzidine[J].Food Research International,2002,35:619-626.
[31]Shcherba V,Babitskaya V,Kurchenko V,et al.Antioxidant properties of fungal melanin pigments[J].Applied Biochemistry and Microbiology,2000,36(5):491-495.