南京市鼓楼区中老年居民幽门螺杆菌感染现状及相关因素研究
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摘要
目的了解南京市鼓楼区中老年居民幽门螺杆菌(HP)感染现状及其危险因素,为制定正确有效的预防措施提供依据。方法 2017年5～8月对南京市鼓楼区935例居民进行尿素14 C呼气试验测定,分析其感染率;同时应用调查问卷开展危险因素调查,采用单因素和多因素logistic回归分析幽门螺杆菌相关危险因素。结果 935例居民中366例(39.14%)HP阳性;单因素logistic回归分析显示有消化道疾病史、消化道不适、是否吃辛辣和方便食品与HP感染有关(P<0.05);多因素logistic回归模型拟合发现消化道疾病史与HP感染负相关,而吃辛辣和方便食品与HP感染正相关(P<0.05)。结论南京市鼓楼区居民幽门螺杆菌感染率较全国水平低,但感染仍普遍存在,应加强对消化道疾病的筛查与治疗,大力宣传健康安全的饮食习惯,积极预防幽门螺杆菌感染与传播。
Objective To understand the current status of Helicobacter pylori(HP)infection among middleaged and elderly residents in Gulou district of Nanjing,to analyze the risk factors and to provide bases for making proper and effective preventive measures. Methods A questionnaire survey was conducted among 935 residents in Gulou district and 14 C urea breath test(14 C-UBT)was performed for H.Pylori infection from May to August in 2017,Risk factors were analyzed using univariate and multivariate logistic regression. Results Among 935 residents,366 were positive for HP with the infection rate of 39.14%.A single-factor logistic regression analysis showed that history of gastrointestinal diseases,digestive tract discomfort,spicy food and ready-to-eat food were major factors associated with HP infection(P<0.05).A multivariate logistic regression fitting model analysis revealed that the history of gastrointestinal disease was negatively associated with HP infection,while spicy foods and ready-to-eat foods were positively associated with HP infection(P<0.05). Conclusions Even though the prevalence of H.pylori among middle-aged and elderly residents in Gulou district of Nanjing is lower than that of the national average.The infection is still widespread.It is necessary to strengthen the screening and treatment of digestive diseases,vigorously promote healthy and safe eating habits,and actively prevent H.pylori infection and bacteria spreading.
Objective To understand the current status of Helicobacter pylori(HP)infection among middleaged and elderly residents in Gulou district of Nanjing,to analyze the risk factors and to provide bases for making proper and effective preventive measures. Methods A questionnaire survey was conducted among 935 residents in Gulou district and 14 C urea breath test(14 C-UBT)was performed for H.Pylori infection from May to August in 2017,Risk factors were analyzed using univariate and multivariate logistic regression. Results Among 935 residents,366 were positive for HP with the infection rate of 39.14%.A single-factor logistic regression analysis showed that history of gastrointestinal diseases,digestive tract discomfort,spicy food and ready-to-eat food were major factors associated with HP infection(P<0.05).A multivariate logistic regression fitting model analysis revealed that the history of gastrointestinal disease was negatively associated with HP infection,while spicy foods and ready-to-eat foods were positively associated with HP infection(P<0.05). Conclusions Even though the prevalence of H.pylori among middle-aged and elderly residents in Gulou district of Nanjing is lower than that of the national average.The infection is still widespread.It is necessary to strengthen the screening and treatment of digestive diseases,vigorously promote healthy and safe eating habits,and actively prevent H.pylori infection and bacteria spreading.
引文
[1]李兴川,王海东,张妮,等.中国儿童及青少年幽门螺杆菌感染流行病学调查的系统评价和Meta分析[J].临床儿科杂志,2017,35(10):782-787.
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[9]刘捷,王永红,罗蓉,等.重庆地区13 C尿素呼气试验阳性的健康体检人群幽门螺杆菌感染率及相关危险因素分析[J].重庆医科大学学报,2017,42(10):1358-1362.
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[12]张天哲,张铁民,赵丹丹,等.中国人群幽门螺杆菌感染相关因素的Meta分析[J].世界华人消化杂志,2009,17(15):1582-1589.
[13]陈世耀,刘天舒,樊晓明,等.上海地区幽门螺杆菌感染及其危险因素调查[J].中华医学杂志,2005,85(12):802-806.
[14]康艳蓉.某社区1452例中老年人幽门螺旋杆菌感染情况分析[J].健康教育与健康促进,2010,5(1):52-53.
[15]卢平,周力,张永宏.贵阳市老年人幽门螺杆菌感染及影响因素分析[J].中国公共卫生,2007,23(3):268-269.
[16]刘敏,郑士全,张林,等.生活习惯与幽门螺杆菌感染的相关性探讨[J].山东医药,2006,46(23):78-79.
[17]贾明芳,骆小红,汪俊兰,等.2180名武汉市居民幽门螺杆菌感染现状及危险因素分析[J].护理学报,2016,23(18):48-52.
[18]徐顺福,施瑞华,张国新,等.江苏地区幽门螺杆菌感染及其危险因素调查[J].世界华人消化杂志,2006,14(35):3363-3370.
[19]薛彦萍.消化性溃疡患者幽门螺杆菌感染状况及影响因素分析[J].河南医学研究,2015,24(1):98-99.
[20]陈利,贾雪梅,王书学.北京密云地区体检人群幽门螺杆菌感染现状及危险因素分析[J].中国综合临床,2017,33(10):891-894.
[21]黄荣根,王春敏,吕敏慧,等.体检人群幽门螺杆菌感染相关因素分析[J].中国现代医学杂志,2011,21(5):671-674.
[22]李方.消化性溃疡幽门螺杆菌感染状况及影响因素分析[J].心血管病防治知识(学术版),2013,24(10):81-83.
[23]陈意振,姚麒,刘颖.幽门螺杆菌感染流行病学的多因素分析[J].中华医院感染学杂志,2013,23(3):543-544.
[24]贾德梅,王嫱,褚南疆,等.云南高原地区成人健康体检人群中幽门螺杆菌感染流行病学调查及相关因素分析[J].重庆医学,2018,47(7):950-956.
[2]包英,杨元素,罗丹.健康体检成年人群幽门螺杆菌感染的相关因素研究[J].中国现代医学杂志,2016,26(12):127-130.
[3]孔辉,庄园,毛方圆,等.肾上腺髓质素在幽门螺杆菌感染中的表达调控及其功能的初步研究[J].第三军医大学学报,2018,40(3):183-189.
[4] Pan BL,Huang CF,Chuah SK,et al.Relationship between Helicobacter pylori infection and bone mineral density:a retrospective cross-sectional study[J].BMC Gastroenterol,2018,18(1):54.
[5]陈莫耶,孙明军.幽门螺杆菌感染与消化系统肿瘤相关性研究进展[J].临床军医杂志,2018,46(1):115-118,120.
[6] Park J,Forman D,Waskito L,et al.Epidemiology of helicobacter pylori and CagA-Positive infections and global variations in gastric cancer[J].Toxins,2018,10(4):163.
[7]张艳君,刘奕婷,于晓松.健康体检人群幽门螺杆菌感染情况与相关因素分析[J].临床军医杂志,2015,43(11):809-812.
[8]崔健丽,刘晶茹,潘丽,等.幽门螺杆菌在健康人群体检中感染状况的调查分析[J].中国临床研究,2011,24(4):349-350.
[9]刘捷,王永红,罗蓉,等.重庆地区13 C尿素呼气试验阳性的健康体检人群幽门螺杆菌感染率及相关危险因素分析[J].重庆医科大学学报,2017,42(10):1358-1362.
[10] Assaad S,Chaaban R,Tannous F,et al.Dietary habits and Helicobacter pylori infection:a cross sectional study at a Lebanese hospital[J].BMC Gastroenterol,2018,18(1):48.
[11]张万岱,胡伏莲,萧树东,等.中国自然人群幽门螺杆菌感染的流行病学调查[J].现代消化及介入诊疗,2010,15(5):265-270.
[12]张天哲,张铁民,赵丹丹,等.中国人群幽门螺杆菌感染相关因素的Meta分析[J].世界华人消化杂志,2009,17(15):1582-1589.
[13]陈世耀,刘天舒,樊晓明,等.上海地区幽门螺杆菌感染及其危险因素调查[J].中华医学杂志,2005,85(12):802-806.
[14]康艳蓉.某社区1452例中老年人幽门螺旋杆菌感染情况分析[J].健康教育与健康促进,2010,5(1):52-53.
[15]卢平,周力,张永宏.贵阳市老年人幽门螺杆菌感染及影响因素分析[J].中国公共卫生,2007,23(3):268-269.
[16]刘敏,郑士全,张林,等.生活习惯与幽门螺杆菌感染的相关性探讨[J].山东医药,2006,46(23):78-79.
[17]贾明芳,骆小红,汪俊兰,等.2180名武汉市居民幽门螺杆菌感染现状及危险因素分析[J].护理学报,2016,23(18):48-52.
[18]徐顺福,施瑞华,张国新,等.江苏地区幽门螺杆菌感染及其危险因素调查[J].世界华人消化杂志,2006,14(35):3363-3370.
[19]薛彦萍.消化性溃疡患者幽门螺杆菌感染状况及影响因素分析[J].河南医学研究,2015,24(1):98-99.
[20]陈利,贾雪梅,王书学.北京密云地区体检人群幽门螺杆菌感染现状及危险因素分析[J].中国综合临床,2017,33(10):891-894.
[21]黄荣根,王春敏,吕敏慧,等.体检人群幽门螺杆菌感染相关因素分析[J].中国现代医学杂志,2011,21(5):671-674.
[22]李方.消化性溃疡幽门螺杆菌感染状况及影响因素分析[J].心血管病防治知识(学术版),2013,24(10):81-83.
[23]陈意振,姚麒,刘颖.幽门螺杆菌感染流行病学的多因素分析[J].中华医院感染学杂志,2013,23(3):543-544.
[24]贾德梅,王嫱,褚南疆,等.云南高原地区成人健康体检人群中幽门螺杆菌感染流行病学调查及相关因素分析[J].重庆医学,2018,47(7):950-956.