幽门螺杆菌感染与动脉粥样硬化性脑梗死的相关性研究
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摘要
目的研究分析幽门螺杆菌感染(HP)在临床中与动脉粥样硬化性脑梗死之间的相关性。方法随机抽取在2017年1月至2018年7月到我院就诊的70例动脉粥样硬化性脑梗死患者,归为观察组;并选择同期入院的非急性脑梗死患者70例,归为对照组。对两组研究对象HP感染情况、颈动脉彩超、血脂等情况进行分析。结果观察组中有40例为HP阳性,所占比重为57.1%(40/70),30例为HP阴性,所占比重为42.9%(30/70)。对照组中有28例为HP阳性,所占比重为40.0%(28/70),42例为HP阴性,所占比重为60.0%(42/70)。比较两组研究对象HP阳性率情况,差异显著(χ~2=5.788,P=0.016)。同HP阴性组比较,HP阳性组TC、LDL-C、TG指标水平较高(P<0.05),而HDL-C指标水平较低(P<0.05),斑块不稳定率较高(P<0.05);HP阳性组ApoA1、ApoB、叶酸、维生素B12水平较HP阴性组明显更低(P<0.05),FIB、HCY水平较HP阴性组明显更高(P<0.05);HP感染严重程度与TC、LDL-C、TG、FIB、HCY等项目水平呈正相关(P<0.05),与HDL-C、ApoA1、ApoB、叶酸、维生素B12指标水平呈负相关(P<0.05)。结论在临床中,HP感染是动脉粥样硬化性脑梗死的主要危险因素,在脑卒中防控中不仅需要对传统的危险因素进行干预,还需要对HP感染进行干预。并以此为动脉粥样硬化性脑梗死的临床防控工作提供新的参考依据。
Objective To analyze the correlation between Helicobacter pylori infection(HP) and atherosclerotic cerebral infarction. Methods Seventy patients with atherosclerotic cerebral infarction who were admitted to our hospital from January 2017 to July 2018 were randomly selected and assigned to the observation group. Seventy patients with non-acute cerebral infarction admitted in the same period were selected as control group. The crowd was classified as a control group. The HP infection, carotid ultrasound and blood lipids were analyzed in the two groups. Results Of the observation group, 40 were HP positive, accounting for 57.1%(40/70), and 30 were HP negative, accounting for 42.9%(30/70). In the control group, 28 cases were positive for HP, accounting for 40.0%(28/70), and 42 cases were HP negative, accounting for 60.0%(42/70). The HP positive rate of the two groups was compared, and the difference was significant(χ~2=5.788, P=0.016). Compared with the HP-negative group, the HP-positive group had higher levels of TC, LDL-C, and TG(P<0.05), while the HDL-C index was lower(P<0.05), and the plaque instability rate was higher(P<0.05); ApoA1, ApoB and HCY levels in HP positive group were significantly lower than those in HP negative group(P<0.05), The levels of FIB and HCY were significantly higher than those of HP negative group(P<0.05); the severity of HP infection was related to TC, LDL-C, TG, FIB, HCY, etc. In the red font part of the abstract section, folic acid, vitamin B12 and HCY, the description of the correlation is reversed. The project level was positively correlated(P<0.05), with HDL-C, ApoA1, ApoB, folic acid, and vitamin B12 in the red font section of the abstract section, the description of the correlation between folic acid, vitamin B12, and HCY was reversed. The indicator level was negatively correlated(P<0.05). Conclusion In clinical practice, HP infection is the main risk factor of atherosclerotic cerebral infarction. In the prevention and control of stroke, not only the traditional risk factors should be intervened, but also the HP infection should be intervened. And provide a new reference for clinical prevention and control of atherosclerotic cerebral infarction.
Objective To analyze the correlation between Helicobacter pylori infection(HP) and atherosclerotic cerebral infarction. Methods Seventy patients with atherosclerotic cerebral infarction who were admitted to our hospital from January 2017 to July 2018 were randomly selected and assigned to the observation group. Seventy patients with non-acute cerebral infarction admitted in the same period were selected as control group. The crowd was classified as a control group. The HP infection, carotid ultrasound and blood lipids were analyzed in the two groups. Results Of the observation group, 40 were HP positive, accounting for 57.1%(40/70), and 30 were HP negative, accounting for 42.9%(30/70). In the control group, 28 cases were positive for HP, accounting for 40.0%(28/70), and 42 cases were HP negative, accounting for 60.0%(42/70). The HP positive rate of the two groups was compared, and the difference was significant(χ~2=5.788, P=0.016). Compared with the HP-negative group, the HP-positive group had higher levels of TC, LDL-C, and TG(P<0.05), while the HDL-C index was lower(P<0.05), and the plaque instability rate was higher(P<0.05); ApoA1, ApoB and HCY levels in HP positive group were significantly lower than those in HP negative group(P<0.05), The levels of FIB and HCY were significantly higher than those of HP negative group(P<0.05); the severity of HP infection was related to TC, LDL-C, TG, FIB, HCY, etc. In the red font part of the abstract section, folic acid, vitamin B12 and HCY, the description of the correlation is reversed. The project level was positively correlated(P<0.05), with HDL-C, ApoA1, ApoB, folic acid, and vitamin B12 in the red font section of the abstract section, the description of the correlation between folic acid, vitamin B12, and HCY was reversed. The indicator level was negatively correlated(P<0.05). Conclusion In clinical practice, HP infection is the main risk factor of atherosclerotic cerebral infarction. In the prevention and control of stroke, not only the traditional risk factors should be intervened, but also the HP infection should be intervened. And provide a new reference for clinical prevention and control of atherosclerotic cerebral infarction.
引文
[1]谭雯,黄宇新,汪海东,等.幽门螺杆菌感染与老年2型糖尿病患者动脉粥样硬化的相关性研究[J].老年医学与保健,2017,23(2):89-92.
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[15]王龙,王复郁,赵学敏,等.脑卒中高危人群幽门螺杆菌感染与颈动脉粥样硬化进展关系的研究[J].中华神经科杂志,2016,49(10):780-784.
[16]李诺,刘鹏亮,蔡爽,等.幽门螺杆菌相关蛋白在脑梗死患者血清中的表达[J].中国微生态学杂志,2016,28(5):558-560.
[17]张文海,梁艳平,杨建,等.幽门螺杆菌感染与老年高血压患者新发心脑血管疾病的相关性研究[J].中华医院感染学杂志,2016,26(24):5604-5606.
[18]程静,吴晓,董言斌,等.幽门螺杆菌感染和老年颈动脉粥样硬化的关系[J].医学研究杂志,2017,46(11):128-131.
[2]王集华.幽门螺杆菌感染与颈动脉粥样硬化相关性研究[J].实用医药杂志,2016,33(3):204-206.
[3]王欢,熊梅,付丽,等.2型糖尿病患者颈动脉粥样硬化与幽门螺旋杆菌感染的相关性研究[J].临床和实验医学杂志,2017,16(11):1116-1119.
[4]吕建萌,袁婕,雷琦,等.幽门螺杆菌细胞毒素相关蛋白A与动脉粥样硬化性脑梗死的关系[J].临床误诊误治,2017,30(4):80-82.
[5]班春梅,艾菊,饶卫平,等.糖尿病患者幽门螺杆菌感染与颈动脉粥样硬化的相关性研究[J].中华医院感染学杂志,2017,27(21):4877-4879.
[6]杜洁,杨维,张桂侠,等.幽门螺杆菌感染与血脂代谢及动脉粥样硬化的相关性[J].现代检验医学杂志,2017,32(4):104-106.
[7]张琦.幽门螺旋杆菌感染与颈动脉粥样硬化患者同型半胱氨酸水平相关性分析[J].实用检验医师杂志,2016,8(1):29-31.
[8]张丽,张保朝,王璐,等.冠状动脉粥样硬化性心脏病患者细胞毒素相关蛋白基因A幽门螺杆菌感染状况研究[J].中华医院感染学杂志,2017,27(13):2928-2931.
[9]曲正.CagA阳性幽门螺杆菌感染、同型半胱氨酸水平、糖尿病颈动脉粥样硬化相关性分析[J].临床合理用药杂志,2016,9(32):111-112.
[10]刘舒,李永秋,高轩,等.慢性幽门螺杆菌感染对脑梗死复发及血流动力学的影响[J].中国老年学杂志,2016,36(12):2909-2912.
[11]井立省,王德昭,邹爱春,等.幽门螺杆菌和平均血小板体积与冠心病相关性分析[J].中国心血管病研究,2016,14(11):1000-1004.
[12]王蕴倩,陈宝平,时军.慢性肾衰竭患者幽门螺旋杆菌感染与血浆脂蛋白相关磷脂酶A2及颈动脉粥样硬化的关系[J].中国动脉硬化杂志,2016,24(6):603-606.
[13]卢晓旭,卢学锋,邱敬涛,等.HP感染与超声检测颈动脉粥样硬化程度和MMP-9及内脂素的相关性研究[J].中华医院感染学杂志,2016,26(22):5141-5143.
[14]刘巧萍.幽门螺杆菌和眼底动脉硬化与冠心病相关性分析[J].吉林医学,2016,37(12):2945-2946.
[15]王龙,王复郁,赵学敏,等.脑卒中高危人群幽门螺杆菌感染与颈动脉粥样硬化进展关系的研究[J].中华神经科杂志,2016,49(10):780-784.
[16]李诺,刘鹏亮,蔡爽,等.幽门螺杆菌相关蛋白在脑梗死患者血清中的表达[J].中国微生态学杂志,2016,28(5):558-560.
[17]张文海,梁艳平,杨建,等.幽门螺杆菌感染与老年高血压患者新发心脑血管疾病的相关性研究[J].中华医院感染学杂志,2016,26(24):5604-5606.
[18]程静,吴晓,董言斌,等.幽门螺杆菌感染和老年颈动脉粥样硬化的关系[J].医学研究杂志,2017,46(11):128-131.