Fibulin-1在2型糖尿病微血管病变患者血清中的表达
摘要
目的:探究2型糖尿病微血管病变患者血清中腓骨蛋白-1(Fibulin-1)的表达,初步分析Fibulin-1与糖尿病微血管病变的相关性。方法 :选取糖尿病合并微血管病变患者62例、单纯糖尿病患者18例及健康体检者20例,采用酶联免疫吸附法检测患者血清中Fibulin-1的含量,并应用SPSS软件分析Fibulin-1与糖尿病微血管病变的相关性。结果:糖尿病患者血清Fibulin-1含量显著高于健康人群(P<0.05);合并微血管病变的糖尿病患者血清Fibulin-1含量显著高于单纯糖尿病患者(P<0.05),血清中Fibulin-1浓度与空腹血糖值呈正相关。同时,合并糖尿病视网膜病变和糖尿病肾病患者血清中Fibulin-1表达显著高于仅合并一种微血管病变者(P<0.05)。结论:Fibulin-1在糖尿病微血管病变发生、发展过程中发挥重要作用。
引文
[1]DAHL JS, M?LLER JE, VIDEB?K L, et al. Plasma fibulin-1 is linked to restrictive filling of the left ventricle and to mortality in patients with aortic valve stenosis[J]. J Am Heart Assoc, 2012, 1(6):e003889.
[2]SCHOLZE A, BLADBJERG EM, SIDELMANN JJ, et al.Plasma concentrations of extracellular matrix protein fibulin-1 are related to cardiovascular risk markers in chronic kidney disease and diabetes[J]. Cardiovasc Diabetol, 2013,12:6.
[3]CANGEMI C, SKOV V, POULSEN MK, et al. Fibulin-1 is a marker for arterial extracellular matrix alterations in type 2diabetes[J]. Clin Chem, 2011, 57(11):1556-1565.
[4]CANGEMI C, HANSEN ML, ARGRAVES WS, et al. Fibulins and their role in cardiovascular biology and disease[J]. Adv Clin Chem, 2014, 67:245-265.
[5]中华医学会糖尿病学分会.中国2型糖尿病防治指南(2013年版)[J].中华糖尿病杂志, 2014, 7:447-498.
[6]ARGRAVES WS, TRAN H, BURGESS WH, et al. Fibulin is an extracellular matrix and plasma glycoprotein with repeated domain structure[J]. J Cell Biol, 1990, 111(6 Pt 2):3155-3164.
[7]ARGRAVES WS, GREENE LM, COOLEY MA, et al. Fibulins:physiological and disease perspectives[J]. EMBO Rep,2003, 4(12):1127-1131.
[8]HANSEN ML, RASMUSSEN LM. Associations between plasma fibulin-1, pulse wave velocity and diabetes in patients with coronary heart disease[J]. J Diabetes Complications, 2015,29(3):362-366.
[9]DU M, FAN X, HONG E, et al. Interaction of oncogenic papillomavirus E6 proteins with fibulin-1[J]. Biochem Biophys Res Commun, 2002, 296(4):962-969.
[10]杨欢,付海龙,毛佳慧,等.血清外体内fibulin-1检测在胃癌诊断中的应用[J].临床检验杂志, 2016, 34(2):107-109.
[11]傅斌生,刘炜,张剑文,等.肝细胞肝癌患者血清和肝癌组织中fibulin-1蛋白的表达及其临床意义[J].中华肝脏外科手术学电子杂志, 2013, 2(3):175-179.
[12]PAAPSTEL K, ZILMER M, EHA J, et al. Association between fibulin-1 and aortic augmentation index in male patients with peripheral arterial disease[J]. Eur J Vasc Endovasc Surg, 2016, 51(1):76-82.
[13]董小英,周贺,张如意. 2型糖尿病合并颈动脉病变患者血浆Fibulin-1蛋白检测及与相关代谢指标的关系[J].宁夏医科大学学报, 2017, 39(7):764-767.
[14]王慧,娄晋宁.糖尿病微血管病变机制的研究进展[J].医学研究杂志, 2010, 39(8):101-104.
[2]SCHOLZE A, BLADBJERG EM, SIDELMANN JJ, et al.Plasma concentrations of extracellular matrix protein fibulin-1 are related to cardiovascular risk markers in chronic kidney disease and diabetes[J]. Cardiovasc Diabetol, 2013,12:6.
[3]CANGEMI C, SKOV V, POULSEN MK, et al. Fibulin-1 is a marker for arterial extracellular matrix alterations in type 2diabetes[J]. Clin Chem, 2011, 57(11):1556-1565.
[4]CANGEMI C, HANSEN ML, ARGRAVES WS, et al. Fibulins and their role in cardiovascular biology and disease[J]. Adv Clin Chem, 2014, 67:245-265.
[5]中华医学会糖尿病学分会.中国2型糖尿病防治指南(2013年版)[J].中华糖尿病杂志, 2014, 7:447-498.
[6]ARGRAVES WS, TRAN H, BURGESS WH, et al. Fibulin is an extracellular matrix and plasma glycoprotein with repeated domain structure[J]. J Cell Biol, 1990, 111(6 Pt 2):3155-3164.
[7]ARGRAVES WS, GREENE LM, COOLEY MA, et al. Fibulins:physiological and disease perspectives[J]. EMBO Rep,2003, 4(12):1127-1131.
[8]HANSEN ML, RASMUSSEN LM. Associations between plasma fibulin-1, pulse wave velocity and diabetes in patients with coronary heart disease[J]. J Diabetes Complications, 2015,29(3):362-366.
[9]DU M, FAN X, HONG E, et al. Interaction of oncogenic papillomavirus E6 proteins with fibulin-1[J]. Biochem Biophys Res Commun, 2002, 296(4):962-969.
[10]杨欢,付海龙,毛佳慧,等.血清外体内fibulin-1检测在胃癌诊断中的应用[J].临床检验杂志, 2016, 34(2):107-109.
[11]傅斌生,刘炜,张剑文,等.肝细胞肝癌患者血清和肝癌组织中fibulin-1蛋白的表达及其临床意义[J].中华肝脏外科手术学电子杂志, 2013, 2(3):175-179.
[12]PAAPSTEL K, ZILMER M, EHA J, et al. Association between fibulin-1 and aortic augmentation index in male patients with peripheral arterial disease[J]. Eur J Vasc Endovasc Surg, 2016, 51(1):76-82.
[13]董小英,周贺,张如意. 2型糖尿病合并颈动脉病变患者血浆Fibulin-1蛋白检测及与相关代谢指标的关系[J].宁夏医科大学学报, 2017, 39(7):764-767.
[14]王慧,娄晋宁.糖尿病微血管病变机制的研究进展[J].医学研究杂志, 2010, 39(8):101-104.