辣椒素对心肌梗死大鼠心功能及梗死面积的影响
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摘要
目的探讨辣椒素灌胃治疗对心肌梗死大鼠心功能及梗死面积的影响及机制。方法 30只健康雄性SD大鼠,结扎冠状动脉左前降支造模,随机分为假手术组、心肌梗死组、辣椒素治疗组。所有大鼠计算心脏/体重比,采用BI-2000医学图像分析系统计算各组心肌梗死面积,超声影像系统分别测定左心室收缩末期容积(LVESV)、左心室舒张末期容积(LVEDV),并明显计算左心室射血分数(LVEF)。结果心肌梗死组LVEDV、LVESV、心脏/体重比、梗死面积均明显增加,而LVEF明显减少;经辣椒素治疗后所有数据都明显发生相反的变化(均P<0.05)。结论辣椒素灌胃可改善心功能及保护心肌,可以把辣椒素作为新型的心血管系统保护药物。
引文
1 王玉姝,李欢,宋东伟,等.龙甲血脉通胶囊对大鼠心肌缺血及心肌缺血再灌注损伤的保护作用[J].现代药物与临床,2013;28(1):25-8.
2 马育轩,郭蕊珠,周海纯,等.心肌缺血再灌注损伤的中医药治疗研究进展[J].中医药信息,2013;30(5):116-8.
3 韩淑燕,马旭,李海霞,等.三七总皂苷对大鼠心肌缺血的保护作用[J].中国药理学与毒理学杂志,2012;26(4):499-503.
4 熊年,韦晟.银杏内酯 B 对大鼠心肌缺血再灌注损伤的保护作用及机制研究[J].中国现代应用药学,2015;32(3):289-94.
5 宗巧凤,程向阳,于影,等.内啡肽-1 后处理对大鼠心肌缺血再灌注损伤的实验研究[J].中国临床药理学与治疗学,2015;20(2):132-7.
6 周剑,吴荣,王龙,等.三七总皂苷通过活化骨髓来源的间充质干细胞改善急性心肌梗死大鼠的心功能[J].细胞与分子免疫学杂志,2018;34(7):605-11.
7 Marunouchi T,Yano E,Tanonaka K.Effects of cardiosphere-derived cell transplantation on cardiac mitochondrial oxygen consumption after myocardial infarction in rats[J].Biomed Pharmacother,2018;108(6):883-92.
8 Fang Y,Chen S,Liu Z,et al.Endothelial stem cells attenuate cardiac apoptosis via downregulating cardiac micro RNA-146a in a rat model of coronary heart disease[J].Exp Ther Med,2018;16(5):4246-52.
9 Cooper HA,Eguchi S.Inhibition of mitochondrial fission as a novel therapeutic strategy to reduce mortality upon myocardial infarction[J].Clin Sci(Lond),2018;132(20):2163-7.
10 Guo W,Liu X,Li J,et al.Prdx1 alleviates cardiomyocyte apoptosisthrough ROS-activated MAPK pathway during myocardial ischemia/reperfusion injury[J].Int J Biol Macromol,2018;112(9):608-15.
11 Yu J,Cao X,Zheng Y,et al.Abnormal expression of miR133a in patients with acute myocardial infarction following radical surgery for gastric cancer and the underlying mechanism[J].Mol Med Rep,2018;18(6):5023-9.
12 Parodi-Rullán RM,Soto-Prado J,Vega-Lugo J,et al.Divergent effects of cyclophilin-D inhibition on the female rat heart:Acute versus chronic post-myocardial infarction[J].Cell Physiol Biochem,2018;50(1):288-303.
13 Hua J,Liu Z,Liu Z,et al.Metformin increases cardiac rupture after myocardial infarction via the AMPK-MTOR/PGC-1α signaling pathway in rats with acute myocardial infarction[J].Med Sci Monit,2018;57(24):6989-7000.
2 马育轩,郭蕊珠,周海纯,等.心肌缺血再灌注损伤的中医药治疗研究进展[J].中医药信息,2013;30(5):116-8.
3 韩淑燕,马旭,李海霞,等.三七总皂苷对大鼠心肌缺血的保护作用[J].中国药理学与毒理学杂志,2012;26(4):499-503.
4 熊年,韦晟.银杏内酯 B 对大鼠心肌缺血再灌注损伤的保护作用及机制研究[J].中国现代应用药学,2015;32(3):289-94.
5 宗巧凤,程向阳,于影,等.内啡肽-1 后处理对大鼠心肌缺血再灌注损伤的实验研究[J].中国临床药理学与治疗学,2015;20(2):132-7.
6 周剑,吴荣,王龙,等.三七总皂苷通过活化骨髓来源的间充质干细胞改善急性心肌梗死大鼠的心功能[J].细胞与分子免疫学杂志,2018;34(7):605-11.
7 Marunouchi T,Yano E,Tanonaka K.Effects of cardiosphere-derived cell transplantation on cardiac mitochondrial oxygen consumption after myocardial infarction in rats[J].Biomed Pharmacother,2018;108(6):883-92.
8 Fang Y,Chen S,Liu Z,et al.Endothelial stem cells attenuate cardiac apoptosis via downregulating cardiac micro RNA-146a in a rat model of coronary heart disease[J].Exp Ther Med,2018;16(5):4246-52.
9 Cooper HA,Eguchi S.Inhibition of mitochondrial fission as a novel therapeutic strategy to reduce mortality upon myocardial infarction[J].Clin Sci(Lond),2018;132(20):2163-7.
10 Guo W,Liu X,Li J,et al.Prdx1 alleviates cardiomyocyte apoptosisthrough ROS-activated MAPK pathway during myocardial ischemia/reperfusion injury[J].Int J Biol Macromol,2018;112(9):608-15.
11 Yu J,Cao X,Zheng Y,et al.Abnormal expression of miR133a in patients with acute myocardial infarction following radical surgery for gastric cancer and the underlying mechanism[J].Mol Med Rep,2018;18(6):5023-9.
12 Parodi-Rullán RM,Soto-Prado J,Vega-Lugo J,et al.Divergent effects of cyclophilin-D inhibition on the female rat heart:Acute versus chronic post-myocardial infarction[J].Cell Physiol Biochem,2018;50(1):288-303.
13 Hua J,Liu Z,Liu Z,et al.Metformin increases cardiac rupture after myocardial infarction via the AMPK-MTOR/PGC-1α signaling pathway in rats with acute myocardial infarction[J].Med Sci Monit,2018;57(24):6989-7000.