不规则抗体检测及IgG抗-A(B)血型抗体效价在多次妊娠史孕妇产前检查中的临床价值
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摘要
目的:探究在多次妊娠史孕妇产前检查中不规则抗体及IgG抗-A(B)血型抗体效价检测的临床价值。方法:选取进行孕期检查的450例孕妇作为研究对象,所有孕妇均进行不规则抗体检测,同时检测O型孕妇产前IgG抗-A(B)血型抗体效价。比较初次妊娠孕妇与多次妊娠史孕妇产前不规则抗体检测阳性情况及IgG抗-A(B)血型抗体效价阳性检出率。结果:多次妊娠孕妇不规则抗体阳性率(5.38%)明显高于初次妊娠孕妇不规则抗体阳性率(1.05%),其差异具有统计学意义(χ~2=6.008,P=0.014);多次妊娠孕妇IgG抗-A(B)血型抗体效价阳性发生率(71.43%)明显高于初次妊娠孕妇IgG抗-A(B)血型抗体效价阳性发生率(48.48%),其差异具有统计学意义(χ~2=8.204,P=0.004)。结论:在多次妊娠史孕妇产前检查中不规则抗体及IgG抗-A(B)血型抗体效价检测具有重要的临床价值,能够早期诊断和干预新生儿溶血病,实现优生优育。
Objective:To explore the clinical value of irregular antibody detection and IgG anti-Ab blood group antibody titer in prenatal examination of pregnant women with multiple pregnancy history.Methods:450 pregnant women who were examined during pregnancy in our hospital were selected as the subjects of this study.All pregnant women were tested for irregular antibodies.At the same time,the titer of IgG blood group antibody of O type pregnant women before delivery was detected.The positive rate of irregular antibody detection and IgG anti Ab before pregnancy were compared between the first pregnant women and the pregnant women with multiple pregnancy history.The titer of blood group antibody was positive.Results:The positive rate of irregular antibody(5.38%)in pregnant women with multiple pregnancies was significantly higher than that of irregular antibody in pregnant women(1.05 %).The difference was statistically significant(χ~2=6.008,P=0.014).The positive rate(71.43%)of IgG antiA(B)blood type antibody in pregnant women with multiple pregnancies was significantly higher than that of IgG anti-A(B)blood type antibody(48.48%)in primary pregnant women.The difference was statistically significant(χ~2=8.204,P=0.004).Conclusion:In prenatal examination of pregnant women with multiple pregnancy history,the detection of irregular antibody and IgG anti-Ab blood group antibody titer has important clinical value,it can early diagnose and interfere with neonatal hemolytic disease,and realize eugenic and excellent birth.
Objective:To explore the clinical value of irregular antibody detection and IgG anti-Ab blood group antibody titer in prenatal examination of pregnant women with multiple pregnancy history.Methods:450 pregnant women who were examined during pregnancy in our hospital were selected as the subjects of this study.All pregnant women were tested for irregular antibodies.At the same time,the titer of IgG blood group antibody of O type pregnant women before delivery was detected.The positive rate of irregular antibody detection and IgG anti Ab before pregnancy were compared between the first pregnant women and the pregnant women with multiple pregnancy history.The titer of blood group antibody was positive.Results:The positive rate of irregular antibody(5.38%)in pregnant women with multiple pregnancies was significantly higher than that of irregular antibody in pregnant women(1.05 %).The difference was statistically significant(χ~2=6.008,P=0.014).The positive rate(71.43%)of IgG antiA(B)blood type antibody in pregnant women with multiple pregnancies was significantly higher than that of IgG anti-A(B)blood type antibody(48.48%)in primary pregnant women.The difference was statistically significant(χ~2=8.204,P=0.004).Conclusion:In prenatal examination of pregnant women with multiple pregnancy history,the detection of irregular antibody and IgG anti-Ab blood group antibody titer has important clinical value,it can early diagnose and interfere with neonatal hemolytic disease,and realize eugenic and excellent birth.
引文
[1]陆礼全,张丽兴,林锐.孕妇产前血型不规则抗体检测临床分析[J].生物医学工程学进展,2016,37(1):42-44.
[2]杨冬梅,李志坚.不规则抗体致新生儿溶血病的检测结果分析[J].中国药物与临床,2016,16(3):438-439.
[3] Brooks S,Squires JE.Hemolytic disease of the fetus and newborn caused by anti-Lan[J].Transfusion,2014,54(5):1317-1320.
[4] Susanna S,Irmeli N,Malla K,et al.Diagnosis and treatment of severe hemolytic disease of the fetus and newborn:a 10-year nationwide retrospective study[J].Acta Obstetricia Et Gynecologica Scandinavica,2015,94(4):383-390.
[5]季相兰.茵栀黄口服液治疗母婴血型不合临床观察[J].陕西中医,2016,37(1):25-26.
[6]李长浩.微柱凝胶法检测不规则抗体的临床应用研究[J].检验医学与临床,2014,11(21):3040-3042.
[7]周雄飞,郑君,毛开新.ABO新生儿溶血病与O型血孕妇孕中期血清IgG抗A(B)抗体效价的关系分析[J].实用临床医药杂志,2015,19(1):85-88.
[8] Kumar R,Saini N,Kaur P,et al.Severe ABO Hemolytic Disease of Newborn with High Maternal Antibody Titres in a Direct Antiglobulin Test Negative Neonate[J].Indian Journal of Pediatrics,2016,83(7):740-741.
[9] Watchko JF,Triulzi D.Need to clarify the cause of hemolysis in case report of newborn with clinically significant hemolytic disease and passive transfer of anti-D from maternal RhIG[J].Transfusion,2014,54(11):3017-3018.
[10]马经琼,谢孝森.不同妊娠次数O型血孕妇新生儿ABO溶血病发生情况及其与体内抗体效价的相关性研究[J].解放军医药杂志,2017,29(4):95-98.
[11]支红霞,周优树,邹标.O型血孕妇血清IgG抗体效价与新生儿溶血病的相关性研究[J].中国当代医药,2016,23(15):127-129.
[12]袁洪斌,易平枝.不同剂量丙种球蛋白治疗新生儿ABO溶血病临床疗效对比观察[J].临床和实验医学杂志,2015,14(10):802-805.
[13]张丹,申晓环,张静蕊.孕妇IgG抗A或抗B效价与ABO系统新生儿溶血病的关系[J].临床军医杂志,2013,41(11):1182-1184.
[14]李江萍,廖国林,谢跃文,等.孕期血型抗体监测与医学干预对新生儿溶血病发病率的影响[J].中国妇幼保健,2016,31(4):871-872.
[15]房笃智,姚伟.O型血孕妇血清IgG抗体效价与新生儿ABO溶血的关系[J].中国优生与遗传杂志,2015,23(11):76-77,79.
[16]杨庆,应海燕,张冬梅,等.孕母O型血清ABO抗体效价对新生儿溶血的影响分析[J].陕西医学杂志,2015,44(12):1617-1619.
[17]梁结玲,曾月婷,莫水群,等.不规则抗体检测及血型抗体效价在多次妊娠中的意义[J].热带医学杂志,2017,17(10):1368-1370.
[18]潘小良,宋朝晖,梁巧米,等.凝聚胺法与微柱凝集法检测孕妇IgG血型抗体效价应用比较[J].中国医药导报,2014,11(8):85-87.
[2]杨冬梅,李志坚.不规则抗体致新生儿溶血病的检测结果分析[J].中国药物与临床,2016,16(3):438-439.
[3] Brooks S,Squires JE.Hemolytic disease of the fetus and newborn caused by anti-Lan[J].Transfusion,2014,54(5):1317-1320.
[4] Susanna S,Irmeli N,Malla K,et al.Diagnosis and treatment of severe hemolytic disease of the fetus and newborn:a 10-year nationwide retrospective study[J].Acta Obstetricia Et Gynecologica Scandinavica,2015,94(4):383-390.
[5]季相兰.茵栀黄口服液治疗母婴血型不合临床观察[J].陕西中医,2016,37(1):25-26.
[6]李长浩.微柱凝胶法检测不规则抗体的临床应用研究[J].检验医学与临床,2014,11(21):3040-3042.
[7]周雄飞,郑君,毛开新.ABO新生儿溶血病与O型血孕妇孕中期血清IgG抗A(B)抗体效价的关系分析[J].实用临床医药杂志,2015,19(1):85-88.
[8] Kumar R,Saini N,Kaur P,et al.Severe ABO Hemolytic Disease of Newborn with High Maternal Antibody Titres in a Direct Antiglobulin Test Negative Neonate[J].Indian Journal of Pediatrics,2016,83(7):740-741.
[9] Watchko JF,Triulzi D.Need to clarify the cause of hemolysis in case report of newborn with clinically significant hemolytic disease and passive transfer of anti-D from maternal RhIG[J].Transfusion,2014,54(11):3017-3018.
[10]马经琼,谢孝森.不同妊娠次数O型血孕妇新生儿ABO溶血病发生情况及其与体内抗体效价的相关性研究[J].解放军医药杂志,2017,29(4):95-98.
[11]支红霞,周优树,邹标.O型血孕妇血清IgG抗体效价与新生儿溶血病的相关性研究[J].中国当代医药,2016,23(15):127-129.
[12]袁洪斌,易平枝.不同剂量丙种球蛋白治疗新生儿ABO溶血病临床疗效对比观察[J].临床和实验医学杂志,2015,14(10):802-805.
[13]张丹,申晓环,张静蕊.孕妇IgG抗A或抗B效价与ABO系统新生儿溶血病的关系[J].临床军医杂志,2013,41(11):1182-1184.
[14]李江萍,廖国林,谢跃文,等.孕期血型抗体监测与医学干预对新生儿溶血病发病率的影响[J].中国妇幼保健,2016,31(4):871-872.
[15]房笃智,姚伟.O型血孕妇血清IgG抗体效价与新生儿ABO溶血的关系[J].中国优生与遗传杂志,2015,23(11):76-77,79.
[16]杨庆,应海燕,张冬梅,等.孕母O型血清ABO抗体效价对新生儿溶血的影响分析[J].陕西医学杂志,2015,44(12):1617-1619.
[17]梁结玲,曾月婷,莫水群,等.不规则抗体检测及血型抗体效价在多次妊娠中的意义[J].热带医学杂志,2017,17(10):1368-1370.
[18]潘小良,宋朝晖,梁巧米,等.凝聚胺法与微柱凝集法检测孕妇IgG血型抗体效价应用比较[J].中国医药导报,2014,11(8):85-87.