老年肺栓塞患者血清D二聚体、血小板平均体积和同型半胱氨酸检测的临床价值
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摘要
目的探讨血清D二聚体(D-D)、血小板平均体积(MPV)和同型半胱氨酸(Hcy)联合检测对老年肺栓塞(PE)患者的临床价值。方法选择2015年2月至2017年5月在航天中心医院确诊的116例PE患者作为研究组,同期100例健康体检者作为对照组,两组对象均进行血清D-D、MPV和Hcy检测,记录检测结果,并进行统计学分析。结果研究组患者D-D、MPV和Hcy水平显著高于对照组(P<0.05);且重度患者的D-D、MPV和Hcy水平显著高于轻度患者(P<0.05);两组单独检测D-D、MPV和Hcy检出率有显著差异,三组指标联合检测使PE诊断率提高达91.38%(P<0.05)。结论 PE患者血清D-D、MPV和Hcy水平显著高于健康人群,且与PE严重程度有关,三者联合检测对老年PE有较高的诊断价值。
Objective To investigate the clinical value of combined detection of the serum D-dimer( D-D),Mean platelet volume( MPV) and Homocysteine( Hcy) in elderly patients with pulmonary embolism. Methods Choice in February 2015 to May 2017 in our hospital 116 cases of patients with pulmonary embolism confirmed as a team,at the same time receive physical examination of 100 cases as control group,two groups of objects are serum D-D,MPV and Hcy detection,record test results,and statistical analysis. In 116 cases of elderly patients with pulmonary embolism as experimental group,100 healthy controls,from February 2015 to May 2017 in Aerospace Central Hospital,were studied in a case-control manner. Serum levels of serum D-D、MPV、Hcy were examined. Then we record the test results,and analyze them by statistics. Results The results showed that the levels of D-D,MPV and Hcy were significantly higher in the experimental group than in the control group( P < 0. 05). The levels of D-D,MPV and Hcy were significantly higher in patients with severe patients than those with mild( P < 0. 05). The levels of D-D,MPV and Hcy were significantly higher in severe patients than mild patients( P < 0. 05). The detection rates of DD,MPV and Hcy were significantly different in the two groups,and the detection rate of the three groups of indexes was significantly improved,up to 91. 38%( P < 0. 05).. Conclusion The levels of D-D,MPV and Hcy in patients with pulmonary embolism are significantly higher than those in the normal population,and related to the severity of the disease. The combined detection of the three has a higher diagnostic value for elderly pulmonary embolism.
Objective To investigate the clinical value of combined detection of the serum D-dimer( D-D),Mean platelet volume( MPV) and Homocysteine( Hcy) in elderly patients with pulmonary embolism. Methods Choice in February 2015 to May 2017 in our hospital 116 cases of patients with pulmonary embolism confirmed as a team,at the same time receive physical examination of 100 cases as control group,two groups of objects are serum D-D,MPV and Hcy detection,record test results,and statistical analysis. In 116 cases of elderly patients with pulmonary embolism as experimental group,100 healthy controls,from February 2015 to May 2017 in Aerospace Central Hospital,were studied in a case-control manner. Serum levels of serum D-D、MPV、Hcy were examined. Then we record the test results,and analyze them by statistics. Results The results showed that the levels of D-D,MPV and Hcy were significantly higher in the experimental group than in the control group( P < 0. 05). The levels of D-D,MPV and Hcy were significantly higher in patients with severe patients than those with mild( P < 0. 05). The levels of D-D,MPV and Hcy were significantly higher in severe patients than mild patients( P < 0. 05). The detection rates of DD,MPV and Hcy were significantly different in the two groups,and the detection rate of the three groups of indexes was significantly improved,up to 91. 38%( P < 0. 05).. Conclusion The levels of D-D,MPV and Hcy in patients with pulmonary embolism are significantly higher than those in the normal population,and related to the severity of the disease. The combined detection of the three has a higher diagnostic value for elderly pulmonary embolism.
引文
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[3]马婉蓉,宋艳丽,吴先正.急性肺栓塞诊断及预后生物标记物的研究进展[J].中华临床医师杂志(电子版),2015,9(10):1911-1915.
[4]黄建,吴刚.多层螺旋CT肺动脉成像右心室参数评估急性肺栓塞的临床研究[J].中国医学影像学杂志,2017,25(04):270-273.
[5]李家耀.D-D二聚体测定在肺栓塞与深静脉栓塞诊断中的应用价值[J].中外医学研究,2016,14(34):40-41.
[6]秦艳茹,张春芳.急性肺栓塞患者血小板动态变化与预后的相关性分析[J].临床肺科杂志,2016,21(07):1264-1267+1278.
[7]范文茂,张社兵,唐良秋,等.血小板平均体积及D二聚体检测在肺栓塞的价值[J].血栓与止血学,2017,23(03):421-423+427.
[8]吴越,袁开芬,赵国厚.同型半胱氨酸在老年肺栓塞早期诊断及病情评估中的意义[J].中国老年保健医学,2015,13(04):78-80.