血清髓过氧化物酶水平与慢性乙型肝炎患者乙型肝炎病毒DNA载量的相关性研究
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摘要
目的探讨血清髓过氧化物酶(MPO)水平与慢性乙型肝炎(CHB)患者乙型肝炎病毒DNA(HBVDNA)载量的相关性。方法选取2013年5月—2014年6月廊坊市人民医院收治的CHB患者124例为观察组,同时选取在本院体检中心体检健康者103例为对照组;将观察组患者按照HBV-DNA拷贝数分为低载量组(10~3 Copies/ml10~7 Copies/ml)25例。比较对照组、观察组以及3个亚组受试者肝功能指标〔丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)〕、血脂指标〔三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)〕及血清MPO、C反应蛋白(CRP)、甲胎蛋白(AFP)水平,并分析血清MPO水平与HBV-DNA载量的相关性。结果对照组与观察组受试者血清TC、HDL-C水平比较,差异无统计学意义(P>0.05);观察组患者血清ALT、AST、TG、LDL-C、MPO、CRP、AFP水平均高于对照组(P<0.05)。低载量组、中载量组、高载量组患者ALT、AST、TG、TC、LDL-C、HDL-C、MPO、CRP及AFP水平比较,差异无统计学意义(P>0.05)。Pearson相关性分析结果显示,血清MPO水平与HBV-DNA载量无直线相关性(r=0.254,P>0.05)。结论血清MPO水平与CHB患者HBV-DNA载量无直线相关性。
Objective To investigate the correlation between serum myeloperoxidase( MPO) level and HBV-DNA load of patients with chronic hepatitis B. Methods From May 2013 to June 2014 in the People's Hospital of Langfang,a total of 124 patients with chronic hepatitis B were selected as observation group,a total of 103 healthy people admitted to this hospital for physical examination were selected as case group; according to HBV-DNA load,patients of observation group were divided three subgroups: A group( 10~3 Copies / ml < HBV-DNA ≤ 10~5 Copies / ml, n = 51), B group( 10~5 Copies / ml < HBV-DNA ≤ 10~7 Copies / ml,n = 48),C group( HBV-DNA > 10~7 Copies / ml,n = 25). Liver function index( including ALT and AST),blood lipids index( including TG,TC,LDL-C and HDL-C),serum levels of MPO,CRP and AFP were compared between control group and observation group,among the three subgroups,and correlation between serum MPO level and HBV-DNA load was analyzed. Results No statistically significant differences of serum level of TC or HDL-C was found between control group and observation group,while serum levels of ALT,AST,TG,LDL-C,MPO, CRP, AFP of observation group were statistically significantly higher than those of control group( P < 0. 05). No statistically significant differences of serum level of ALT,AST,TG,TC, LDL-C, HDL-C, MPO, CRP or AFP was found among the three subgroups( P > 0. 05). Pearson correlation analysis showed that,serum MPO level was not linearly correlated with HBV-DNA load of patients with chronic hepatitis B( r =0. 254,P > 0. 05). Conclusion Serum MPO level is not linearly correlated with HBV-DNA load of patients with chronic hepatitis B.
Objective To investigate the correlation between serum myeloperoxidase( MPO) level and HBV-DNA load of patients with chronic hepatitis B. Methods From May 2013 to June 2014 in the People's Hospital of Langfang,a total of 124 patients with chronic hepatitis B were selected as observation group,a total of 103 healthy people admitted to this hospital for physical examination were selected as case group; according to HBV-DNA load,patients of observation group were divided three subgroups: A group( 10~3 Copies / ml < HBV-DNA ≤ 10~5 Copies / ml, n = 51), B group( 10~5 Copies / ml < HBV-DNA ≤ 10~7 Copies / ml,n = 48),C group( HBV-DNA > 10~7 Copies / ml,n = 25). Liver function index( including ALT and AST),blood lipids index( including TG,TC,LDL-C and HDL-C),serum levels of MPO,CRP and AFP were compared between control group and observation group,among the three subgroups,and correlation between serum MPO level and HBV-DNA load was analyzed. Results No statistically significant differences of serum level of TC or HDL-C was found between control group and observation group,while serum levels of ALT,AST,TG,LDL-C,MPO, CRP, AFP of observation group were statistically significantly higher than those of control group( P < 0. 05). No statistically significant differences of serum level of ALT,AST,TG,TC, LDL-C, HDL-C, MPO, CRP or AFP was found among the three subgroups( P > 0. 05). Pearson correlation analysis showed that,serum MPO level was not linearly correlated with HBV-DNA load of patients with chronic hepatitis B( r =0. 254,P > 0. 05). Conclusion Serum MPO level is not linearly correlated with HBV-DNA load of patients with chronic hepatitis B.
引文
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[14]潘棱,沈晓丽,郑乐民,等.探讨髓过氧化物酶与急性冠脉综合征的关系[J].心血管康复医学杂志,2012,21(6):579-581.
[15]刘迎迎,张玲.髓过氧化物酶在急性胰腺炎发病机制中的作用[J].临床肝胆病杂志,2010,26(5):493-495.
[16]徐萍,徐东升,陈江,等.髓过氧化物酶对炎症性肠病病情活动监测的临床价值[J].江西医药,2006,41(10):732-734.
[17]骆抗先.乙型肝炎基础和临床[M].第2版.北京:人民卫生出版社,2001:136-137.
[18]刘勇,周洲.抗中性粒细胞胞浆抗体在转氨酶升高的乙肝患者中的检测[J].大家健康,2013,7(6):42-43.
[19]李文卉,汪年松.抗中性粒细胞胞浆抗体相关性系统性血管炎发病机制研究进展[J].中国中西医结合肾病杂志,2009,10(4):366-369.
[2]马庆华,邓爱云,张钲,等.髓过氧化物酶对急性冠状动脉综合征患者的早期临床筛查价值[J].西安交通大学学报:医学版,2012,33(6):719-722.
[3]吴士礼,刘进军,邵杉,等.血浆髓过氧化物酶与冠状动脉斑块炎症反应及病变程度的相关性[J].实用医学杂志,2009,25(23):3971-3973.
[4]袁振兴,董博,顾小红.慢性乙型肝炎患者HBV病毒载量与髓过氧化物酶检测分析[J].肝胆外科杂志,2015,23(4):292-294.
[5]中华医学会肝病学分会.慢性乙型肝炎防治指南(2010年版)方案[J].中华内科杂志,2011,16(6):351-366.
[6]慢性乙型肝炎抗病毒治疗专家委员会.慢性乙型肝炎抗病毒治疗专家共识[J].中华实验和临床感染病杂志:电子版,2010,4(1):82-91.
[7]张秋红,张春瑞.慢性乙型病毒性肝炎患者病毒复制与肝组织损伤和肝纤维化的关系[J].广东医学,2010,31(19):2518-2520.
[8]李志方,林敏,黄思聪,等.血清HBV-DNA载量与转氨酶值及肝纤维化血清学指标相关性研究[J].检验医学与临床,2011,8(7):813-814,816.
[9]周萍,孙慧伶,朱肖鸿,等.慢性乙型肝炎患者血清HBV DNA载量与肝组织病理学变化关系研究[J].实用肝脏病杂志,2014,19(4):364-367.
[10]张春兰,石亚玲.肝纤维化指标与病毒含量及病理的关系[J].临床肝胆病杂志,2000,16(4):220-221.
[11]郭如意,余青,余雪平,等.HBeA g阳性慢性乙型肝炎患者血清HBeA g与肝组织病理的相关性研究[J].中国人兽共患病学报,2014,30(4):397-401,408.
[12]曹碧红,温帆渊,叶彩丽.慢性肝炎患者乙型肝炎病毒复制与肝纤维化标志物的关系[J].临床医学与临床,2008,5(7):398-399.
[13]马庆华,邓爱云,张钲,等.髓过氧化物酶对急性冠脉综合征患者的早期临床筛查价值[J].西安交通大学学报:医学版,2012,33(6):719-722.
[14]潘棱,沈晓丽,郑乐民,等.探讨髓过氧化物酶与急性冠脉综合征的关系[J].心血管康复医学杂志,2012,21(6):579-581.
[15]刘迎迎,张玲.髓过氧化物酶在急性胰腺炎发病机制中的作用[J].临床肝胆病杂志,2010,26(5):493-495.
[16]徐萍,徐东升,陈江,等.髓过氧化物酶对炎症性肠病病情活动监测的临床价值[J].江西医药,2006,41(10):732-734.
[17]骆抗先.乙型肝炎基础和临床[M].第2版.北京:人民卫生出版社,2001:136-137.
[18]刘勇,周洲.抗中性粒细胞胞浆抗体在转氨酶升高的乙肝患者中的检测[J].大家健康,2013,7(6):42-43.
[19]李文卉,汪年松.抗中性粒细胞胞浆抗体相关性系统性血管炎发病机制研究进展[J].中国中西医结合肾病杂志,2009,10(4):366-369.