摘要
目的探讨血清髓过氧化物酶(MPO)水平与慢性乙型肝炎(CHB)患者乙型肝炎病毒DNA(HBVDNA)载量的相关性。方法选取2013年5月—2014年6月廊坊市人民医院收治的CHB患者124例为观察组,同时选取在本院体检中心体检健康者103例为对照组;将观察组患者按照HBV-DNA拷贝数分为低载量组(10~3 Copies/ml10~7 Copies/ml)25例。比较对照组、观察组以及3个亚组受试者肝功能指标〔丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)〕、血脂指标〔三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)〕及血清MPO、C反应蛋白(CRP)、甲胎蛋白(AFP)水平,并分析血清MPO水平与HBV-DNA载量的相关性。结果对照组与观察组受试者血清TC、HDL-C水平比较,差异无统计学意义(P>0.05);观察组患者血清ALT、AST、TG、LDL-C、MPO、CRP、AFP水平均高于对照组(P<0.05)。低载量组、中载量组、高载量组患者ALT、AST、TG、TC、LDL-C、HDL-C、MPO、CRP及AFP水平比较,差异无统计学意义(P>0.05)。Pearson相关性分析结果显示,血清MPO水平与HBV-DNA载量无直线相关性(r=0.254,P>0.05)。结论血清MPO水平与CHB患者HBV-DNA载量无直线相关性。
Objective To investigate the correlation between serum myeloperoxidase( MPO) level and HBV-DNA load of patients with chronic hepatitis B. Methods From May 2013 to June 2014 in the People's Hospital of Langfang,a total of 124 patients with chronic hepatitis B were selected as observation group,a total of 103 healthy people admitted to this hospital for physical examination were selected as case group; according to HBV-DNA load,patients of observation group were divided three subgroups: A group( 10~3 Copies / ml < HBV-DNA ≤ 10~5 Copies / ml, n = 51), B group( 10~5 Copies / ml < HBV-DNA ≤ 10~7 Copies / ml,n = 48),C group( HBV-DNA > 10~7 Copies / ml,n = 25). Liver function index( including ALT and AST),blood lipids index( including TG,TC,LDL-C and HDL-C),serum levels of MPO,CRP and AFP were compared between control group and observation group,among the three subgroups,and correlation between serum MPO level and HBV-DNA load was analyzed. Results No statistically significant differences of serum level of TC or HDL-C was found between control group and observation group,while serum levels of ALT,AST,TG,LDL-C,MPO, CRP, AFP of observation group were statistically significantly higher than those of control group( P < 0. 05). No statistically significant differences of serum level of ALT,AST,TG,TC, LDL-C, HDL-C, MPO, CRP or AFP was found among the three subgroups( P > 0. 05). Pearson correlation analysis showed that,serum MPO level was not linearly correlated with HBV-DNA load of patients with chronic hepatitis B( r =0. 254,P > 0. 05). Conclusion Serum MPO level is not linearly correlated with HBV-DNA load of patients with chronic hepatitis B.
引文
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