超声弹性成像应变比鉴别肉芽肿性乳腺炎与乳腺癌的价值分析
摘要
目的探讨超声弹性成像应变比在鉴别诊断肉芽肿性乳腺炎与乳腺癌的价值研究。方法回顾性的分析2016年1月-2018年12月于我院就诊的33例肉芽肿性乳腺炎患者及55例乳腺癌患者,所有患者均行乳腺超声弹性成像检查,计算并比较两组的超声弹性成像应变比。绘制工作特征曲线(ROC)并计算灵敏度、特异度、诊断界值和曲线下面积(AUC)。结果肉芽肿性乳腺炎患者的病灶直径为19. 5±10. 4 mm,乳腺癌患者病灶直径为18. 8±12. 5 mm,两组间比较无统计学差异(P>0. 05);超声弹性成像的结果显示,肉芽肿性乳腺炎患者的应变比为1. 5±0. 9,明显低于乳腺癌患者的5. 6±4. 3,两组间比较差异有统计学意义(P<0. 05)。ROC曲线分析结果显示,区分肉芽肿性乳腺炎和乳腺癌的最佳应变比诊断界值为2. 5,诊断肉芽肿性乳腺炎的敏感性和特异性分别为87. 3%和96. 2%,曲线下面积为0. 939(95%CI:0. 885-0. 996; P<0. 001)。结论超声弹性应变比对于鉴别肉芽肿性乳腺炎与乳腺癌具有较好的应用价值,有助于临床上的下一步决策。
引文
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[3]KIM J Y,SHIN J K,Lee S H.The Breast Tumor Strain Ratio Is a Predictive Parameter for Axillary Lymph Node Metastasis in Patients With Invasive Breast Cancer[J].AJR Am J Roentgenol,2015,205(6):W630.
[4]FUJII M,MIZUTANI Y,SAKUMA T,et al.Corynebacterium kroppenstedtii in granulomatous mastitis:Analysis of formalin-fixed,paraffin-embedded biopsy specimens by immunostaining using low-specificity bacterial antisera and real-time polymerase chain reaction[J].Pathology International,2018,68(7):409.
[5]YAGCI B,ERDEM TOSLAK I,CEKIC B,et al.Differentiation between idiopathic granulomatous mastitis and malignant breast lesions using strain ratio on ultrasonic elastography[J].Diagnostic and Interventional Imaging,2017,98(10):685.
[6]XU Y,BAI X,CHEN Y,et al.Application of real-time elastography ultrasound in the diagnosis of axillary lymph node metastasis in breast cancer patients[J].Scientific reports,2018,8(1):102.