系统性红斑狼疮患者外周血RDW-CV和PLT/NEUT%与相关免疫学指标及病情活动度的相关性
|
摘要
目的探讨红细胞分布宽度变异系数(RDW-CV)和血小板与中性粒细胞百分比比值(PLT/NEUT%)与系统性红斑狼疮(SLE)相关免疫学指标及病情活动度的相关性。方法回顾性分析128例SLE患者与128例健康对照的资料;比较两组RDW-CV和PLT/NEUT%水平,分析RDW-CV和PLT/NEUT%与CRP,ESR,C3,C4,IgG和SLEDAI-2000的相关性;评价RDW-CV,PLT/NEUT%及两者联合检测在诊断SLE疾病的价值。结果 SLE组PLT/NEUT%水平低于对照组,而RDW-CV水平高于对照组;PLT/NEUT%与CRP,ESR和IgG呈负相关(r=-0.258～-0.245,均P<0.01);与C3和C4呈正相关(r=0.507,0.309,均P<0.01);RDW-CV与CRP,ESR呈正相关(r=0.391,0.306,均P<0.01),与C3呈负相关(r=-0.236,P:0.07);RDW,PLT/NEUT%和C3与SLEDAI-2000有线性回归关系(t=-5.819～3.075,均P<0.01);两者联合预测值(AUC=0.879)>PLT/NEUT%(AUC=0.861)>RDW-CV(AUC=0.784)。结论 RDW-CV和PLT/NEUT%可作为SLE病情变化的辅助监测指标,与SLE疾病活动度有一定的相关性。
Objective To evaluate the correlation of coefficient of variation of red blood cell distribution width(RDW-CV),platelet(PLT) to proportion of neutrophils(NEUT%),related immunological indexes and disease activity in systemic lupus erythematosus patients.Methods The medical records of 128 SLE patients and 128 healthy controls were retrospectively reviewed.The level of RDW-CV and PLT/NEUT% were compared between two groups.The correlation among RDW-CV,PLT/NEUT%,CRP,ESR,C3,C4,IgG and SLEDAI-2000 were analyzed,and the value of RDW-CV,PLT/NEUT% and the both in diagnosis of SLE disease were evaluated.Results The level of PLT/NEUT% in SLE group was significantly lower than that in healthy controls,and the level of RDW-CV in SLE group was significantly higher than that in healthy controls;PLT/NEUT% was negatively correlated with CRP,ESR and IgG(r=-0.256,-0.258,-0.245,all P<0.01),but was positively correlated with C3 and C4.RDW-CV was positively correlated with CRP,ESR(r=0.391,0.306,all P<0.01),but was negatively correlated with C3(r=-0.236,P=0.07).RDW-CV,PLT/NEUT% and C3 had linear regression relation ship with SLEDAI-2000(t=5.819～3.075,P<0.01),and the predictive value of two combined(AUC=0.868)>PLT/NEUT%(AUC=0.858)>RDW-CV(AUC=0.787).Conclusion RDW-CV and PLT/NEUT% can be used as auxiliary monitoring indexes of SLE condition changed, has certain correlation with SLE disease activity.
Objective To evaluate the correlation of coefficient of variation of red blood cell distribution width(RDW-CV),platelet(PLT) to proportion of neutrophils(NEUT%),related immunological indexes and disease activity in systemic lupus erythematosus patients.Methods The medical records of 128 SLE patients and 128 healthy controls were retrospectively reviewed.The level of RDW-CV and PLT/NEUT% were compared between two groups.The correlation among RDW-CV,PLT/NEUT%,CRP,ESR,C3,C4,IgG and SLEDAI-2000 were analyzed,and the value of RDW-CV,PLT/NEUT% and the both in diagnosis of SLE disease were evaluated.Results The level of PLT/NEUT% in SLE group was significantly lower than that in healthy controls,and the level of RDW-CV in SLE group was significantly higher than that in healthy controls;PLT/NEUT% was negatively correlated with CRP,ESR and IgG(r=-0.256,-0.258,-0.245,all P<0.01),but was positively correlated with C3 and C4.RDW-CV was positively correlated with CRP,ESR(r=0.391,0.306,all P<0.01),but was negatively correlated with C3(r=-0.236,P=0.07).RDW-CV,PLT/NEUT% and C3 had linear regression relation ship with SLEDAI-2000(t=5.819～3.075,P<0.01),and the predictive value of two combined(AUC=0.868)>PLT/NEUT%(AUC=0.858)>RDW-CV(AUC=0.787).Conclusion RDW-CV and PLT/NEUT% can be used as auxiliary monitoring indexes of SLE condition changed, has certain correlation with SLE disease activity.
引文
[1] 钱成荣,田雪梅,李晗,等.红细胞分布宽度和中性粒细胞淋巴细胞比值对类风湿关节炎诊断值的评价[J].标记免疫分析与临床,2016,23(8):888-891.QIAN Chengrong,TIAN Xuemei,LI Han,et al.Evaluation of red blood cell distribution width and neutrophil to lymphocyte ratio in diagnosis of rheumatoid arthritis[J].Labeled Immunoassays and Clinical Medicine,2016,23(8):888-891.
[2] 常俊,谌蓉.中性粒细胞比例评估系统性红斑狼疮病情的应用价值[J].江苏医药,2017,43(23):1707-1710.CHANG Jun,CHEN Rong.Application value of proportion of neutrophils in evaluating illness staus of systemic lupus erythematosus[J].Jiangsu Medical Journal,2017,43(23):1707-1710.
[3] 邵从军,秦淑国.平均血小板体积/血小板比值与系统性红斑狼疮活动性的相关性分析[J].蚌埠医学院学报,2018,43(1),81-83.SHAO Congjun,QIN Shuguo.Correlation analysis be-tween mean platelet volume/platelet ratio and systemic lupus erythematosus activity[J].Journal of Bengbu Medical College,2018,43(1),81-83.
[4] 刘坤锋,吴洁.中性粒细胞胞外诱捕网在自身免疫性疾病中的研究进展[J].药物生物技术,2016,23(1),65-68.LIU Kunfeng,WU Jie.New advances of neutrophil extracellular traps on autoimmune diseases[J].Pharmaceutical Biotechnology,2016,23(1),65-68.
[5] 杨朝美,杨晏.血清淀粉样蛋白A(SAA)在系统性红斑狼疮(SLE)患者中的浓度水平研究[J].中国实验诊断学,2018,22(11):1918-1921.YANG Chaomei,YANG Yan.Study of concentration level of serum amyloid a in patients with SLE[J].Chinese Journal of Laboratory Diagnosis,2018,22(11):1918-1921.
[6] 林笑颖,周明倩,李海昌.中性粒细胞胞外诱捕网在系统性红斑狼疮发病机制中作用的研究进展[J].吉林大学学报(医学版),2018,44(4):886-890.LIN Xiaoying,ZHOU Mingqian,LI Haichang.Research progress in effects of neutrophil extracellular traps in pathogenesis of systemic lupus erythematosus[J].Journal of Jilin University(Medicine Edition),2018,44(4):886-890.
[7] 黄子平,罗朋立.系统性红斑狼疮伴血小板减少机制的研究进展[J].世界最新医学信息文摘,2017,17(32):29-30.HUANG Ziping,LUO Pengli.Research progress of mechanism of systemic lupus erythematosus combined with thrombocytopenia[J].World Latest Medicine Information,2017,17(32):29-30.
[8] JAROUDI S,ALAZZEH A,PEIRIS A N.Red cell width:an emerging and novel biomarker of systemic inflammation[J].South Med J,2017,110(11):744.
[9] 宋小莉,苏娟.红细胞分布宽度在自身免疫性疾病中的研究进展[J].中国全科医学,20017,20(35):4459-4463,4469.SONG Xiaoli,SU Juan.Recent developments in the value of red blood cell distribution width in autoimmune diseases[J].Chinese General Practice,2017,20(35):4459-4463,4469.
[10] HE Yujue,LIU Can,ZENG Zhiyong,et al.Red blo-od cell distribution with:a potential laboratory parameter for monitoring inflammation in rheumatoid arthritis[J].Clin Rheumatol,2018,37(1):161-167.
[11] 黄雅亮,周晓鸿,于秋爽,等.系统性红斑狼疮血液系统损害研究进展[J].皮肤病与性病,2016,38(3):176-181.HUANG Yaliang,ZHOU Xiaohong,YU Qiushuan-g,et al.Advance of haematological complications in systemic lupus erythematosus-A systematic literature[J].Journal of Dermatology and Venereology,2016,38(3):176-181.
[12] 刘晓庆,段亚男,石磊,等.红细胞分布宽度和中性粒细胞/淋巴细胞比值在系统性红斑狼疮中的应用价值[J].中国现代医生,2016,54(33):22-24,29.LIU Xiaoqing,DUAN Ya’nan,SHI Lei,et al.The value of red blood cell distribution width and neutrophil-lymphocyte ratio in systemic lupus erythematosus[J].China Modern Doctor,2016,54(33):22-24,29.
[2] 常俊,谌蓉.中性粒细胞比例评估系统性红斑狼疮病情的应用价值[J].江苏医药,2017,43(23):1707-1710.CHANG Jun,CHEN Rong.Application value of proportion of neutrophils in evaluating illness staus of systemic lupus erythematosus[J].Jiangsu Medical Journal,2017,43(23):1707-1710.
[3] 邵从军,秦淑国.平均血小板体积/血小板比值与系统性红斑狼疮活动性的相关性分析[J].蚌埠医学院学报,2018,43(1),81-83.SHAO Congjun,QIN Shuguo.Correlation analysis be-tween mean platelet volume/platelet ratio and systemic lupus erythematosus activity[J].Journal of Bengbu Medical College,2018,43(1),81-83.
[4] 刘坤锋,吴洁.中性粒细胞胞外诱捕网在自身免疫性疾病中的研究进展[J].药物生物技术,2016,23(1),65-68.LIU Kunfeng,WU Jie.New advances of neutrophil extracellular traps on autoimmune diseases[J].Pharmaceutical Biotechnology,2016,23(1),65-68.
[5] 杨朝美,杨晏.血清淀粉样蛋白A(SAA)在系统性红斑狼疮(SLE)患者中的浓度水平研究[J].中国实验诊断学,2018,22(11):1918-1921.YANG Chaomei,YANG Yan.Study of concentration level of serum amyloid a in patients with SLE[J].Chinese Journal of Laboratory Diagnosis,2018,22(11):1918-1921.
[6] 林笑颖,周明倩,李海昌.中性粒细胞胞外诱捕网在系统性红斑狼疮发病机制中作用的研究进展[J].吉林大学学报(医学版),2018,44(4):886-890.LIN Xiaoying,ZHOU Mingqian,LI Haichang.Research progress in effects of neutrophil extracellular traps in pathogenesis of systemic lupus erythematosus[J].Journal of Jilin University(Medicine Edition),2018,44(4):886-890.
[7] 黄子平,罗朋立.系统性红斑狼疮伴血小板减少机制的研究进展[J].世界最新医学信息文摘,2017,17(32):29-30.HUANG Ziping,LUO Pengli.Research progress of mechanism of systemic lupus erythematosus combined with thrombocytopenia[J].World Latest Medicine Information,2017,17(32):29-30.
[8] JAROUDI S,ALAZZEH A,PEIRIS A N.Red cell width:an emerging and novel biomarker of systemic inflammation[J].South Med J,2017,110(11):744.
[9] 宋小莉,苏娟.红细胞分布宽度在自身免疫性疾病中的研究进展[J].中国全科医学,20017,20(35):4459-4463,4469.SONG Xiaoli,SU Juan.Recent developments in the value of red blood cell distribution width in autoimmune diseases[J].Chinese General Practice,2017,20(35):4459-4463,4469.
[10] HE Yujue,LIU Can,ZENG Zhiyong,et al.Red blo-od cell distribution with:a potential laboratory parameter for monitoring inflammation in rheumatoid arthritis[J].Clin Rheumatol,2018,37(1):161-167.
[11] 黄雅亮,周晓鸿,于秋爽,等.系统性红斑狼疮血液系统损害研究进展[J].皮肤病与性病,2016,38(3):176-181.HUANG Yaliang,ZHOU Xiaohong,YU Qiushuan-g,et al.Advance of haematological complications in systemic lupus erythematosus-A systematic literature[J].Journal of Dermatology and Venereology,2016,38(3):176-181.
[12] 刘晓庆,段亚男,石磊,等.红细胞分布宽度和中性粒细胞/淋巴细胞比值在系统性红斑狼疮中的应用价值[J].中国现代医生,2016,54(33):22-24,29.LIU Xiaoqing,DUAN Ya’nan,SHI Lei,et al.The value of red blood cell distribution width and neutrophil-lymphocyte ratio in systemic lupus erythematosus[J].China Modern Doctor,2016,54(33):22-24,29.