普拉洛芬联合玻璃酸钠治疗老年糖尿病白内障术后干眼症的疗效分析
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摘要
目的探讨分析为老年期糖尿病白内障术后干眼症患者实施普拉洛芬联合玻璃酸钠药物治疗的临床效果。方法 2016年2月-2018年3月,将124例老年期糖尿病白内障术后干眼症患者随机等分为两组,每组62例,为参照组行单纯性玻璃酸钠药物治疗,针对研究组实施普拉洛芬联合玻璃酸钠药物治疗,观察比较两组的治疗有效率指标测算值,以及接受治疗前后的泪膜破裂时间指标测算值、泪液分泌实验指标测算值和角膜荧光染色评分指标测算值。结果研究组的治疗有效率指标测算值(91.93%)高于参照组(70.96%),差异有统计学意义(χ~2=9.021,P<0.05)。治疗前,研究组的泪膜破裂时间指标测算值(4.79±1.14)分、泪液分泌实验指标测算值(2.84±0.89)分,以及角膜荧光染色评分指标测算值(6.51±1.04)分均与参照组(4.72±1.26)分、(2.67±0.96)分、(6.42±1.02)分大致相当,差异无统计学意义(t=0.325,1.023,0.486,P>0.05)。治疗后,研究组的泪膜破裂时间指标测算值(11.06±1.65)分和泪液分泌实验指标测算值(7.32±2.10)分高于参照组(7.49±1.01)分、(5.02±0.81)分,研究组的角膜荧光染色评分指标测算值(2.12±0.67)分低于参照组(4.21±0.66)分,差异有统计学意义(t=14.530,8.046,17.498,P<0.05)。结论为老年期糖尿病白内障术后干眼症患者实施普拉洛芬联合玻璃酸钠药物治疗,能获取较好效果,值得临床推广。
Objective To analyze the clinical effects of pranoprofen combined with sodium hyaluronate in the treatment of dry eye syn-drome in senile diabetic cataract patients. Methods From February 2016 to March 2018, 124 patients with dry eye syndrome after se-nile cataract surgery were randomly divided into two groups, 62 cases in each group. The patients in the reference group were treated with simple sodium hyaluronate. For the study group, pranoprofen combined with sodium hyaluronate was used to observe the thera-peutic efficiency index of the two groups, as well as the measurement of tear film rupture time index before and after treatment, the measurement index of tear secretion test index and corneal fluorescence staining score indicator. Results The therapeutic efficiency index of the study group(91.93%) was higher than that of the reference group(70.96%),the difference was statistically significant(χ~2=9.021, P<0.05). Before treatment, the study group's tear film rupture time index(4.79±1.14), tear secretion test index(2.84±0.89)points,and corneal fluorescence staining index(6.51±1.04)points were compared with the reference group(4.72±1.26)points,(2.67±0.96)points,and(6.42±1.02)points, roughly equivalent,the difference was statistically significant(t=0.325, 1.023, 0.486, P>0.05). After treatment,the calculated tear film rupture time index(11.06±1.65)points and the tear secretion test index(7.32±2.10)points were higher than the reference group(7.49±1.01)points,(5.02±0.81)points, the cornea calculated value of the fluorescence staining index of the study group(2.12±0.67)points was lower than that of the reference group(4.21±0.66)points,the difference was statistically significant(t=14.530,8.046, 17.498, P<0.05). Conclusion The treatment of laparoprofen combined with sodium hyaluronate in elderly patients with cataract surgery after cataract surgery can obtain better results and is worthy of clinical promotion.
Objective To analyze the clinical effects of pranoprofen combined with sodium hyaluronate in the treatment of dry eye syn-drome in senile diabetic cataract patients. Methods From February 2016 to March 2018, 124 patients with dry eye syndrome after se-nile cataract surgery were randomly divided into two groups, 62 cases in each group. The patients in the reference group were treated with simple sodium hyaluronate. For the study group, pranoprofen combined with sodium hyaluronate was used to observe the thera-peutic efficiency index of the two groups, as well as the measurement of tear film rupture time index before and after treatment, the measurement index of tear secretion test index and corneal fluorescence staining score indicator. Results The therapeutic efficiency index of the study group(91.93%) was higher than that of the reference group(70.96%),the difference was statistically significant(χ~2=9.021, P<0.05). Before treatment, the study group's tear film rupture time index(4.79±1.14), tear secretion test index(2.84±0.89)points,and corneal fluorescence staining index(6.51±1.04)points were compared with the reference group(4.72±1.26)points,(2.67±0.96)points,and(6.42±1.02)points, roughly equivalent,the difference was statistically significant(t=0.325, 1.023, 0.486, P>0.05). After treatment,the calculated tear film rupture time index(11.06±1.65)points and the tear secretion test index(7.32±2.10)points were higher than the reference group(7.49±1.01)points,(5.02±0.81)points, the cornea calculated value of the fluorescence staining index of the study group(2.12±0.67)points was lower than that of the reference group(4.21±0.66)points,the difference was statistically significant(t=14.530,8.046, 17.498, P<0.05). Conclusion The treatment of laparoprofen combined with sodium hyaluronate in elderly patients with cataract surgery after cataract surgery can obtain better results and is worthy of clinical promotion.
引文
[1]李孟石,乔军辉,武天坤.玻璃酸钠联合rhEGF滴眼液治疗白内障术后干眼症泪膜的效果及对泪液TNF-α、IL-6水平影响[J].现代诊断与治疗,2017,28(24):4533-4535.
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[3]林龙齐.0.3%玻璃酸钠滴眼液治疗白内障超声乳化联合人工晶体植入术后干眼症的疗效观察[J].临床医学工程,2018,25(7):867-868.
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[5]汪绍娟.玻璃酸钠滴眼液联合重组人表皮生长因子滴眼液治疗白内障术后干眼症的疗效分析[J].武警后勤学院学报:医学版,2018,27(4):311-313.
[6]何星光,龚兰兰,余才翰.玻璃酸钠对白内障超声乳化联合IOL植入术后眼部炎症反应和干眼症的影响[J].国际眼科杂志,2018,18(4):697-701.
[7]秦庆,杨建芳,唐云华.不同术式白内障超声乳化和人工晶体植入术联合对术后干眼症泪膜破裂时间、泪液分泌量及症状评分的影响[J].中外医学研究,2018,16(8):13-15.
[8]曾静燕.玻璃酸钠滴眼液联合重组人表皮生长因子衍生物滴眼液治疗白内障术后干眼症的临床观察[J].北方药学,2018,15(3):131.
[9]陆银萍.玻璃酸钠滴眼液配合七叶洋地黄双苷对白内障超声乳化术后干眼症的应用[J].临床医药文献电子杂志,2018,5(5):180-181.
[10]崔健怡,胡水清.普拉洛芬联合玻璃酸钠治疗白内障术后干眼症的临床疗效分析[J].中国药物经济学,2018(12):71-73.
[2]梁曼.探讨超声乳化白内障吸除联合人工晶体植入术后干眼症患者采取除风益损汤治疗的临床效果[J].中国社区医师,2018,34(22):90-91.
[3]林龙齐.0.3%玻璃酸钠滴眼液治疗白内障超声乳化联合人工晶体植入术后干眼症的疗效观察[J].临床医学工程,2018,25(7):867-868.
[4]赵霞,王英壮,占戈,等.玻璃酸钠联合重组人表皮生长因子滴眼液治疗白内障术后干眼症的临床效果[J].宁夏医科大学学报,2018,40(5):575-578.
[5]汪绍娟.玻璃酸钠滴眼液联合重组人表皮生长因子滴眼液治疗白内障术后干眼症的疗效分析[J].武警后勤学院学报:医学版,2018,27(4):311-313.
[6]何星光,龚兰兰,余才翰.玻璃酸钠对白内障超声乳化联合IOL植入术后眼部炎症反应和干眼症的影响[J].国际眼科杂志,2018,18(4):697-701.
[7]秦庆,杨建芳,唐云华.不同术式白内障超声乳化和人工晶体植入术联合对术后干眼症泪膜破裂时间、泪液分泌量及症状评分的影响[J].中外医学研究,2018,16(8):13-15.
[8]曾静燕.玻璃酸钠滴眼液联合重组人表皮生长因子衍生物滴眼液治疗白内障术后干眼症的临床观察[J].北方药学,2018,15(3):131.
[9]陆银萍.玻璃酸钠滴眼液配合七叶洋地黄双苷对白内障超声乳化术后干眼症的应用[J].临床医药文献电子杂志,2018,5(5):180-181.
[10]崔健怡,胡水清.普拉洛芬联合玻璃酸钠治疗白内障术后干眼症的临床疗效分析[J].中国药物经济学,2018(12):71-73.