LncRNA-ATB在肿瘤中的表达与意义
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摘要
长链非编码RNA(LncRNA)具有多种生物活性,参与了人体的细胞分化、组织发育并且在肿瘤的发生发展过程起重要作用。LncRNA-ATB作为最新发现的长链非编码RNA,在多种肿瘤中存在异常表达以及对肿瘤恶性生物学行为起调控作用,有望成为肿瘤潜在早期诊断标记物和治疗新靶点。然而LncRNA-ATB功能较为复杂,而且在不同肿瘤中通过不同生物学机制发挥致癌或抑癌作用。本文结合国内外文献报道,旨在对LncRNA-ATB在不同肿瘤中的表达水平及作用进行简要综述。
Objective The long non coding RNA(LncRNA) has a variety of biological activities and is involved in cell differentiation, tissue development,which plays an important role in the pathogenesis and development of tumor. As the last discovered long chain of noncoding RNA, LncRNA ATB is abnormally expressed in a variety of tumor,which has regulating effects on malignant tumor biology behavior, which is expected to become the markers for early diagnosis and potential new targets in treatment of tumor. However, the function of LncRNA ATB is comparatively complex, which plays a role of carcinogenesis or anticancer through different biological mechanisms in different tumors. Therefore, combining with domestic and foreign literature reports, this article aims to briefly review the expression levels and effects of LncRNA ATB in different tumors.
Objective The long non coding RNA(LncRNA) has a variety of biological activities and is involved in cell differentiation, tissue development,which plays an important role in the pathogenesis and development of tumor. As the last discovered long chain of noncoding RNA, LncRNA ATB is abnormally expressed in a variety of tumor,which has regulating effects on malignant tumor biology behavior, which is expected to become the markers for early diagnosis and potential new targets in treatment of tumor. However, the function of LncRNA ATB is comparatively complex, which plays a role of carcinogenesis or anticancer through different biological mechanisms in different tumors. Therefore, combining with domestic and foreign literature reports, this article aims to briefly review the expression levels and effects of LncRNA ATB in different tumors.
引文
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36 张欣,王洁,艾丽梅.783例淋巴瘤患者流行病学分析.现代预防医学,2013,40:3908-3912.
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38 赵伟,李晓明.被转化生长因子β活化的长链非编码RNA对人淋巴瘤Raji细胞增殖、周期及凋亡的影响.中国现代医学杂志,2017,27:18-23.
2 Ponting CP,OLiver PL,ReLk W.EvoLution and functions of Long noncoding RNAs.Cell,2009,136:629-641.
3 Spizzo R,Almeida MI,Colombatti A,et al.Long noncoding RNAs and cancer:a new frontier of translational research.Oncogene,2012,31:4577-4587.
4 Wapinski O,Chang HY.Non-coding RNAs and human disease.Trends in cell Biology,2011,21:354-361.
5 Liu YH,Sun SY,Lu CT.Expression of long non-coding RNA in breast cancer tissues and peripheral blood.Chinese J clinicians Electronic,2016,10:1710-1713.
6 Louis DN,Ohqaki H,Wiestler OD,et al.The 2007 WHO classification of tumours of the central nervous system.Acta Neuropathol,2007,114:97-109.
7 Brandsma D ,StaLpers L,TaaL W,et al.Clinical features,mechanisms,and management of pseudoprogression in malignant gliomas.Lancel Oncol,2008,9:453-461.
8 张新雨,马春春,卞尔保,等.敲减长链非编码RNA ATB抑制胶质瘤细胞增殖、迁移和侵袭.安徽医科大学学报,2017,52:1123-1127.
9 Siegel RL,Miller KD,Jemai A.Cancer statistics,2015.CA Cancer J CLin,2015,65:5-29.
10 Janowitz T,Welsh SJ,Zaki K,et al.Adjuvant therapy in renal cell carcinoma-past,present,and future.Semin Oncol,2013,40:482-491.
11 Xiong J,Liu Y,Jiang L,et al.High expression of long non-coding RNA LinRNA-ATB is corre lated with metastases and promotes cell migration and invasion in renal cell carcinoma.Jpn J Clin Oncol,2016,46:378-384.
12 Saito T,Kurashige J,Nambara S,et al.A lang non-coding RNA activated by transforming growth factor-β is an independent prognostic marker of gastric cancer.Ann Surg Oncol,2015,22 suppl 3:S915-922.
13 FerLay J,Shin HR,Bray F,et al.Estimates of worLdwide burden of cancer in 2008:GLOBOCAN 2008.Int J Cancer,2000,127:2893-2917.
14 Calvert PM,Frucht H.The genetics of colorectal cancer.Ann Intem Med,2002,137:603-612.
15 Rupnaraix C,Dlamini Z,Naicker S,et al.Colon cancer,genomics and apoptotic events,Biol Chem,2004,385:449-464.
16 Weitz J,Koch M,Debus J,et al.Colorectal cancer.Lancet,2005,365:153-165.
17 Iguchi T,Uchi R,Nainbara S,et al.A long noncoding RNA, LncRNA-ATB,is Involved in the progression and prognosis of colorectal cancer.Anticancer Res,2015,35:1385-1388.
18 李薇,孙峰,吴雪松,等.LncRNA-ATB促进结肠癌细胞侵袭与转移的机制研究 .中国现代医学杂志,2017,27:33-39.
19 Yang G,Wang Y,Zeng Y,et al.Rapid health transition in China,1990-2010:Findingings from the Global Bruden of Disease Study 2010.The Labcet,2013,381:1987-2015.
20 Nault JC.The end of almost 10 years of negative RCTs in advanced hepatocellular carcinoma.The Lancet,2017,389:4-6.
21 Chun JM,Kwon HJ,Sohn J,et al.Prognostic factors after early recurrence in patients who underwent curative resection for hepatocellular carcinoma.J Surg OncoL,2011,103:148-151.
22 Yuan JH,Yang F,Wang F,et al.A long noncoding RNA activated by TGF-b promotes the TGF-b promotes the invasion-metastasis cascade in hepatocellular carcinoma.Cancer Cell,2014,25:666-681.
23 姜峰,范庆,魏士博,等.LncRNA-ATB在人肝癌组织中的表达及意义.现代肿瘤医学,2017,25:2269-2272.
24 Song X,Yi XM,Tang CP,et al.Long non-coding RNA ATB promotes growth and epithelial-mesenchymal transition and predicts poor prognosis in human prostate carcinoma.Oncology Reports,2016,36:10-22.
25 Xu S,Yi XM,Tang CP,et al.Long non-coding RNA ATB promotes growth and epithelial-mesenchymal transition and predicts poor prognosis in human prostate carcinoma.Oncol Rep,2016,36:10-22.
26 Jennbacken K,Tesan T,Wang W,et al.N-cadherin increases after androgen deprivation and is associated with metases after androgen deprivation and is associated with metastasis in prostate cancer.Endocr Relat Cancer,2010,17:469-479.
27 Qu S,Yang X,Song W,et al.Downregulation of LncRNA-ATB correl- ates with clinical progression and unfavorable prognosis in pancreatic cancer.Tumor Biol,37:3933-3938.
28 Torre LA,Bray F,Siege LRL,et al.Global cancer statistics,2012.CA:a cancer.Journal for clinicians,2015,65:87-108.
29 徐丹,李军用.肺腺癌组织和血清中LncRNA-ATB表达及临床意义分析.临床肿瘤学杂志,2016,21:218-222.
30 Siegel R,Ma J,Zou Z,et al.Cancer statistics,2014.CA:A cancer Journal for Linicians,2014,64:9-29.
31 GonzaLez-Angulo AM,MoraLes-Vasquez F,Hortobagyi GN.Overview of resistance to systemic therapy in patients with breast cancer.Advances in Experimental Medicine and Biology,2007,608:1-22.
32 Slamon DJ,CLark GM,Wong SG,et al.Human breast cancer:correlation of relapse and survival with amplification of the HER-2/neu oncogene.Science,1987,235:177-182.
33 Vu T,CLaret FX.Trastuzumab:updated mechanisms of action and resistance in breast cancer.Frontiers in oncology,2012,2:62.
34 Paik S,Bryant J,Tan-Chiu E,et al.HER2 and choice of adjuvant chemotherapy for invasive breast cancer:national surgical adjuvant breast and bowel project protocoL B-15.JournaL of the National Cancer Institute,2000,92:1991-1998.
35 Shi SJ,Wang LJ,Yu B.LncRNA-ATB promotes trastuzumab resistance and invasionmetastasis cascade in breast cancer.Oncotarget,2015,6:11652-11663.
36 张欣,王洁,艾丽梅.783例淋巴瘤患者流行病学分析.现代预防医学,2013,40:3908-3912.
37 李小秋,李甘地,高子芬,等.中国淋巴瘤亚型分布:国内多中心性病理10002例分析.诊断学理论与实践,2012,11:111-115.
38 赵伟,李晓明.被转化生长因子β活化的长链非编码RNA对人淋巴瘤Raji细胞增殖、周期及凋亡的影响.中国现代医学杂志,2017,27:18-23.