前列地尔联合高频振荡通气治疗新生儿持续肺动脉高压疗效分析
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摘要
目的探讨分析前列地尔联合高频振荡通气(HFOV)治疗新生儿持续肺动脉高压(PPHN)疗效。方法选取我院2017年2月～2018年2月收治的72例PPHN作为研究对象,分为对照组和观察组,对照组给予常规治疗,观察组给予前列地尔联合HFOV治疗。对比分析两组患儿临床治疗效果。结果观察组患儿PH值、动脉氧分压(PaO_2)、血氧饱和度(SaO_2)明显高于对照组,且动脉二氧化碳分压(PaCO_2)、肺动脉压(PASP)明显低于对照组,差异有统计学意义(P <0.05),但两组患儿血压(BP)、心率(HR)差异无统计学意义(P> 0.05);观察组患儿的肺动脉压力(PV)、肺血管阻力(PVR)、体血管阻力(SVR)水平均低于对照组,差异有统计学意义(P <0.05);观察组患儿临床治疗有效率高于对照组,气胸发生率低于对照组,差异有统计学意义(P <0.05);观察组患儿呼吸机使用时间短于对照组患儿,差异有统计学意义(P <0.05)。结论对PPHN患儿采用前列地尔联合HFOV进行治疗,有效改善了患儿临床症状,降低了患儿的肺动脉压,改善了患儿血流动力学,减少了呼吸机使用时间,临床治疗效果显著,具有较高的临床推广价值。
Objective To investigate the effect of alprostadil combined with high-frequency oscillatory ventilation(HFOV) in the treatment of persistent pulmonary hypertension of the newborn(PPHN). Methods Seventytwo cases of PPHN admitted to our hospital from February 2017 to February 2018 were selected as the study subjects and divided into the control group and the observation group.The control group was given conventional treatment,while the observation group was given alprostadil combined with HFOV.The clinical therapeutic effects of the two groups were compared and analyzed. Results The PH value,arterial oxygen partial pressure(PaO_2) and blood oxygen saturation(SaO_2) of the observation group were significantly higher than those of the control group,and the arterial carbon dioxide partial pressure(PaCO_2) and pulmonary artery pressure(PASP) were significantly lower than those of the control group,the difference was statistically significant(P < 0.05).There was no significant difference in blood pressure(BP) and heart rate(HR) between the two groups(P > 0.05).The levels of pulmonary artery pressure(PV),pulmonary vascular resistance(PVR) and body vascular resistance(SVR) in the observation group were all lower than those in the control group,the differences were statistically significant(P < 0.05).The clinical treatment efficiency of the observation group was higher than that of the control group,the incidence of pneumothorax was lower than that of the control group,and the duration of ventilator use was shorter than that of the control group,the difference was statistically significant(P < 0.05). Conclusion The treatment of children with PPHN with alprostol combined with HFOV can effectively improve the clinical symptoms of children,reduce the pulmonary arterial pressure,improve the hemodynamics of children,and reduce the duration of ventilator use.The clinical treatment effect is significant and has high clinical promotion value.
Objective To investigate the effect of alprostadil combined with high-frequency oscillatory ventilation(HFOV) in the treatment of persistent pulmonary hypertension of the newborn(PPHN). Methods Seventytwo cases of PPHN admitted to our hospital from February 2017 to February 2018 were selected as the study subjects and divided into the control group and the observation group.The control group was given conventional treatment,while the observation group was given alprostadil combined with HFOV.The clinical therapeutic effects of the two groups were compared and analyzed. Results The PH value,arterial oxygen partial pressure(PaO_2) and blood oxygen saturation(SaO_2) of the observation group were significantly higher than those of the control group,and the arterial carbon dioxide partial pressure(PaCO_2) and pulmonary artery pressure(PASP) were significantly lower than those of the control group,the difference was statistically significant(P < 0.05).There was no significant difference in blood pressure(BP) and heart rate(HR) between the two groups(P > 0.05).The levels of pulmonary artery pressure(PV),pulmonary vascular resistance(PVR) and body vascular resistance(SVR) in the observation group were all lower than those in the control group,the differences were statistically significant(P < 0.05).The clinical treatment efficiency of the observation group was higher than that of the control group,the incidence of pneumothorax was lower than that of the control group,and the duration of ventilator use was shorter than that of the control group,the difference was statistically significant(P < 0.05). Conclusion The treatment of children with PPHN with alprostol combined with HFOV can effectively improve the clinical symptoms of children,reduce the pulmonary arterial pressure,improve the hemodynamics of children,and reduce the duration of ventilator use.The clinical treatment effect is significant and has high clinical promotion value.
引文
[1]王龙,林新宇,王丽娜,等.前列地尔联合高频振荡通气治疗新生儿持续肺动脉高压疗效分析[J].中国新生儿科杂志,2015,30(1):51-53.
[2]许全珍.前列地尔联合雾化吸入硝普钠治疗新生儿持续肺动脉高压30例疗效分析[J].中国民族民间医药,2013,22(5):90.
[3]梁春华,林春繁,谭海涛,等.前列地尔联合雾化吸入硝普钠治疗新生儿持续肺动脉高压的疗效观察[J].中国医药科学,2016,6(1):65-67,83.
[4]刘渝,易明,段娓.前列地尔治疗新生儿持续性肺动脉高压疗效观察[J].儿科药学杂志,2015,21(12):22-24.
[5]李晓艳,申孟平,宫红梅,等.高频振荡通气联合米力农对新生儿持续性肺动脉高压的效果观察[J].中国妇幼保健,2015,30(18):3096-3098.
[6]申孟平,李晓艳,贾冬梅.高频振荡通气联合西地那非治疗新生儿持续肺动脉高压疗效分析[J].中华实用诊断与治疗杂志,2013,27(1):74-75.
[7]徐慧香,关海山,宋妍妍.持续肺动脉高压新生儿行前列地尔联合雾化吸入硝普钠的临床疗效[J].中国药物经济学,2015,10(3):72-73.
[8]郭佳,王桂田,林莉,等.前列地尔联合硫酸镁治疗新生儿持续肺动脉高压的临床疗效观察[J].实用心脑肺血管病杂志,2015,23(1):85-87.
[9]张岚,刘艳,高琼,等.前列地尔对新生儿持续性肺动脉高压呼吸参数及血流动力学的影响[J].海南医学院学报,2017,23(19):2698-2700,2704.
[10]黄国盛,廖燕,毕雷,等.高频振荡叠加常频通气联合西地那非治疗新生儿持续性肺动脉高压的临床分析[J].中国妇幼保健,2014,29(36):6126-6128.
[11]肖燕燕,韩玲.新生儿持续肺动脉高压诊治[J].中国实用儿科杂志,2015,30(6):421-424.
[12]齐素梅.前列地尔在新生儿肺动脉高压治疗中的效果观察[J].中国医药科学,2013,3(24):78-79.
[13]杨红群.前列地尔联合肺表面活性物质治疗新生儿肺动脉高压的疗效观察[J].海南医学,2013,24(14):2082-2084.
[14]李伙德,苏绍雄,朱晓河.前列地尔与常频通气联合治疗新生儿持续肺动脉高压疗效观察[J].中外医学研究,2013,11(19):23-24.
[15]黄伟星.高频振荡通气联合前列地尔治疗新生儿持续肺动脉高压疗效分析[J].临床医学,2015,35(6):106,109.
[16]张素艳.前列地尔联合高频通气治疗新生儿持续性肺动脉高压效果观察[J].河南医学研究,2016,25(4):695-696.
[2]许全珍.前列地尔联合雾化吸入硝普钠治疗新生儿持续肺动脉高压30例疗效分析[J].中国民族民间医药,2013,22(5):90.
[3]梁春华,林春繁,谭海涛,等.前列地尔联合雾化吸入硝普钠治疗新生儿持续肺动脉高压的疗效观察[J].中国医药科学,2016,6(1):65-67,83.
[4]刘渝,易明,段娓.前列地尔治疗新生儿持续性肺动脉高压疗效观察[J].儿科药学杂志,2015,21(12):22-24.
[5]李晓艳,申孟平,宫红梅,等.高频振荡通气联合米力农对新生儿持续性肺动脉高压的效果观察[J].中国妇幼保健,2015,30(18):3096-3098.
[6]申孟平,李晓艳,贾冬梅.高频振荡通气联合西地那非治疗新生儿持续肺动脉高压疗效分析[J].中华实用诊断与治疗杂志,2013,27(1):74-75.
[7]徐慧香,关海山,宋妍妍.持续肺动脉高压新生儿行前列地尔联合雾化吸入硝普钠的临床疗效[J].中国药物经济学,2015,10(3):72-73.
[8]郭佳,王桂田,林莉,等.前列地尔联合硫酸镁治疗新生儿持续肺动脉高压的临床疗效观察[J].实用心脑肺血管病杂志,2015,23(1):85-87.
[9]张岚,刘艳,高琼,等.前列地尔对新生儿持续性肺动脉高压呼吸参数及血流动力学的影响[J].海南医学院学报,2017,23(19):2698-2700,2704.
[10]黄国盛,廖燕,毕雷,等.高频振荡叠加常频通气联合西地那非治疗新生儿持续性肺动脉高压的临床分析[J].中国妇幼保健,2014,29(36):6126-6128.
[11]肖燕燕,韩玲.新生儿持续肺动脉高压诊治[J].中国实用儿科杂志,2015,30(6):421-424.
[12]齐素梅.前列地尔在新生儿肺动脉高压治疗中的效果观察[J].中国医药科学,2013,3(24):78-79.
[13]杨红群.前列地尔联合肺表面活性物质治疗新生儿肺动脉高压的疗效观察[J].海南医学,2013,24(14):2082-2084.
[14]李伙德,苏绍雄,朱晓河.前列地尔与常频通气联合治疗新生儿持续肺动脉高压疗效观察[J].中外医学研究,2013,11(19):23-24.
[15]黄伟星.高频振荡通气联合前列地尔治疗新生儿持续肺动脉高压疗效分析[J].临床医学,2015,35(6):106,109.
[16]张素艳.前列地尔联合高频通气治疗新生儿持续性肺动脉高压效果观察[J].河南医学研究,2016,25(4):695-696.