叶酸联合VitB_(12)治疗对高血压合并高同型半胱氨酸血症患者血生化指标及颈动脉硬化的影响
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摘要
目的分析叶酸联合VitB12治疗对高血压合并高同型半胱氨酸血症患者血生化指标及颈动脉硬化的影响。方法将本院2015年1月至2016年8月收治的60例高血压合并高同型半胱氨酸血症患者纳入本次实验,采取随机抽签的方式将所有患者分为实验组与对照组,各30例。对照组给予常规治疗,实验组在对照组的基础上应用叶酸联合VitB12治疗,分析两种治疗方案对患者血生化指标及颈动脉硬化的影响。结果实验组患者NO和HDL-C较对照组更高,Hcy和LDL-C较对照组更低;实验组患者D0较对照组更低,FMD较对照组更高;实验组患者IMT、Dis、DC、PWV较对照组更低,CC较对照组更高,两组上述比较差异有统计学意义(P<0.05)。结论高血压合并高同型半胱氨酸血症患者给予叶酸联合VitB12治疗可显著改善其血生化指标,降低颈动脉硬化度,利于降低疾病风险,值得推广。
Objective To analyze the effects of folic acid combined with VitB12 on blood biochemical parameters and carotid atherosclerosis in patients with hypertension complicated with hyperhomocysteinemia. Methods 60 cases of hypertensive patients with hyperhomocysteinemia admitted to our hospital from January 2015 to August 2016 were included in this experiment. All patients were randomly divided into experimental group(30 cases) and control group(30 cases). The control group was given routine treatment, while the experimental group was treated with folic acid combined with VitB12 on the basis of the control group. The effects of the two treatment schemes on blood biochemical parameters and carotid atherosclerosis were analyzed. Results NO and HDL-C in the experimental group were higher than those in the control group, Hcy and LDL-C were lower than those in the control group; D0 in the experimental group was lower than that in the control group, and FMD was higher than that in the control group; IMT, Dis, DC and PWV in the experimental group were lower than those in the control group, and CC was higher than that in the control group, the difference between the two groups was statistically significant(P<0.05). Conclusion Folic acid combined with VitB12 can significantly improve the blood biochemical indexes, reduce the degree of carotid atherosclerosis and reduce the risk of disease in hypertensive patients with hyperhomocysteinemia, which is worthy of promotion.
Objective To analyze the effects of folic acid combined with VitB12 on blood biochemical parameters and carotid atherosclerosis in patients with hypertension complicated with hyperhomocysteinemia. Methods 60 cases of hypertensive patients with hyperhomocysteinemia admitted to our hospital from January 2015 to August 2016 were included in this experiment. All patients were randomly divided into experimental group(30 cases) and control group(30 cases). The control group was given routine treatment, while the experimental group was treated with folic acid combined with VitB12 on the basis of the control group. The effects of the two treatment schemes on blood biochemical parameters and carotid atherosclerosis were analyzed. Results NO and HDL-C in the experimental group were higher than those in the control group, Hcy and LDL-C were lower than those in the control group; D0 in the experimental group was lower than that in the control group, and FMD was higher than that in the control group; IMT, Dis, DC and PWV in the experimental group were lower than those in the control group, and CC was higher than that in the control group, the difference between the two groups was statistically significant(P<0.05). Conclusion Folic acid combined with VitB12 can significantly improve the blood biochemical indexes, reduce the degree of carotid atherosclerosis and reduce the risk of disease in hypertensive patients with hyperhomocysteinemia, which is worthy of promotion.
引文
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[5]孙飞,马向红,李广平,等.血浆同型半胱氨酸水平对原发性高血压患者发生冠心病的预测价值[J].中国全科医学,2012,15(13):1469-1471.
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[7]刘佳,徐援,高霞,等.高同型半胱氨酸血症对原发性高血压患者冠状动脉内皮功能的影响[J].中国循环杂志,2013,28(8):576-580.
[8]程王生.高同型半胱氨酸与冠心病的相关分析[J].当代医学,2016,22(32):54-55.
[9]彭慧,陈苏,王四坤,等.叶酸联合VitB12治疗对高血压合并高同型半胱氨酸血症患者血生化指标及颈动脉硬化的影响[J].海南医学院学报,2016,22(18):2205-2208.
[2]任春艳,刘文忠.叶酸联合依那普利治疗高同型半胱氨酸血症高血压的疗效分析[J].临床合理用药杂志,2017,10(22):13-14.
[3]李志玲,徐新伟,刘玉梅,等.缬沙坦联合叶酸对老年高血压肾病患者降压及降同型半胱氨酸的临床研究[J].中国实用医药,2012,7(22):1-4.
[4]王振宇,周静,张文谦,等.盐敏感性高血压合并高同型半胱氨酸血症的临床研究[J].中国心血管杂志,2017,22(2):90-97.
[5]孙飞,马向红,李广平,等.血浆同型半胱氨酸水平对原发性高血压患者发生冠心病的预测价值[J].中国全科医学,2012,15(13):1469-1471.
[6]刘慧华.H型高血压患者血清同型半胱氨酸水平与颈动脉硬化的关系[J].西部医学,2012,24(8):1539-1541.
[7]刘佳,徐援,高霞,等.高同型半胱氨酸血症对原发性高血压患者冠状动脉内皮功能的影响[J].中国循环杂志,2013,28(8):576-580.
[8]程王生.高同型半胱氨酸与冠心病的相关分析[J].当代医学,2016,22(32):54-55.
[9]彭慧,陈苏,王四坤,等.叶酸联合VitB12治疗对高血压合并高同型半胱氨酸血症患者血生化指标及颈动脉硬化的影响[J].海南医学院学报,2016,22(18):2205-2208.