高尿酸血症与中青年无症状性脑梗死的相关性分析
|
摘要
目的探讨血清尿酸与中青年无症状性脑梗死的关系。方法收集我院中青年患者300例,根据临床神经功能缺损症状及颅脑MRI或CT结果,分为无症状脑梗死组、有症状脑梗死组和对照组,每组100例。测定三组患者的血清尿酸、血脂、血糖水平。将高尿酸脑梗死患者分为口服苯溴马隆控制血尿酸组(控制组)和非控制尿酸组(非控制组)。控制组口服药物苯溴马隆片治疗,非控制组不接受药物治疗,两组每3个月进行随访。对高尿酸水平与中青年脑梗死进行Logistic多因素回归分析。结果无症状脑梗死组、有症状脑梗死组和对照组高尿酸患者分别为41例、57例和18例,差异有统计学意义(P<0.05)。无症状性脑梗死组41例尿酸升高,进展为有症状脑梗死17例,59例尿酸正常,进展为有症状脑梗死7例,差异有统计学意义(P<0.05)。98例高尿酸脑梗死患者中,控制组50例进展为有症状性脑梗死或复发有7例,非控制组48例进展为有症状性脑梗死或复发有17例,差异有统计学意义(P<0.05)。高尿酸水平与中青年脑梗死的发生及进展有相关性(OR=1.31,95%CI=1.003～1.918,P<0.01)。结论高尿酸水平与中青年脑梗死呈正相关,控制高尿酸可有效预防和降低中青年无症状脑梗死进展为急性脑梗死。
Objective To investigate the relationship between serum uric acid and asymptomatic cerebral infarction in young and middle-aged.Methods A total of 300 young and middle-aged patients in our hospital were enrolled. According to the clinical neurological deficit symptoms and brain MRI or CT results, they were divided into asymptomatic cerebral infarction group, symptomatic cerebral infarction group and control group, with 100 cases in each group. Serum uric acid, blood lipids, and blood glucose levels were measured in three groups of patients. Patients with hyperuricemia and cerebral infarction were divided into oral benzbromarone-controlled blood uric acid group(control group) and non-controlled uric acid group(non-control group). The control group received oral drug benzobromone tablets, the non-control group did not receive drug treatment, and the two groups were followed up every 3 months. Logistic multivariate regression analysis was performed on high uric acid level and middle-aged and young cerebral infarction. Results The asymptomatic cerebral infarction group, the symptomatic cerebral infarction group and the control group had41 cases, 57 cases and 18 cases of high uric acid, respectively,the difference was statistically significant( P <0.05). In the asymptomatic cerebral infarction group, 41 patients had elevated uric acid, and 17 patients had symptomatic cerebral infarction. 59 patients had normal uric acid and 7 patients had symptomatic cerebral infarction,the difference was statistically significant( P<0.05).In 98 patients with hyperuricemia cerebral infarction,there were 7 cases of symptomatic cerebral infarction or recurrence in control group(50 cases) and 17 cases of symptomatic cerebral infarction or recurrence in non-control group(48 cases),the difference was statistically significant(P<0.05). The level of high uric acid was correlated with the occurrence and progression of cerebral infarction in young and middle-aged patients(OR=1.31, 95%CI=1.003～1.918, P<0.01). Conclusion The level of high uric acid is positively correlated with cerebral infarction in young and middle-aged patients. Controlling high uric acid can effectively prevent and reduce the progression of asymptomatic cerebral infarction in young and middle-aged patients.
Objective To investigate the relationship between serum uric acid and asymptomatic cerebral infarction in young and middle-aged.Methods A total of 300 young and middle-aged patients in our hospital were enrolled. According to the clinical neurological deficit symptoms and brain MRI or CT results, they were divided into asymptomatic cerebral infarction group, symptomatic cerebral infarction group and control group, with 100 cases in each group. Serum uric acid, blood lipids, and blood glucose levels were measured in three groups of patients. Patients with hyperuricemia and cerebral infarction were divided into oral benzbromarone-controlled blood uric acid group(control group) and non-controlled uric acid group(non-control group). The control group received oral drug benzobromone tablets, the non-control group did not receive drug treatment, and the two groups were followed up every 3 months. Logistic multivariate regression analysis was performed on high uric acid level and middle-aged and young cerebral infarction. Results The asymptomatic cerebral infarction group, the symptomatic cerebral infarction group and the control group had41 cases, 57 cases and 18 cases of high uric acid, respectively,the difference was statistically significant( P <0.05). In the asymptomatic cerebral infarction group, 41 patients had elevated uric acid, and 17 patients had symptomatic cerebral infarction. 59 patients had normal uric acid and 7 patients had symptomatic cerebral infarction,the difference was statistically significant( P<0.05).In 98 patients with hyperuricemia cerebral infarction,there were 7 cases of symptomatic cerebral infarction or recurrence in control group(50 cases) and 17 cases of symptomatic cerebral infarction or recurrence in non-control group(48 cases),the difference was statistically significant(P<0.05). The level of high uric acid was correlated with the occurrence and progression of cerebral infarction in young and middle-aged patients(OR=1.31, 95%CI=1.003～1.918, P<0.01). Conclusion The level of high uric acid is positively correlated with cerebral infarction in young and middle-aged patients. Controlling high uric acid can effectively prevent and reduce the progression of asymptomatic cerebral infarction in young and middle-aged patients.
引文
[1]周青珍.中青年急性脑梗死发生的临床特点及危险因素分析[J].世界临床医学,2015,7(6):60-62.
[2]田野,车玉琴.中青年与老年缺血性卒中患者危险因素的对比研究[J].中国血液流变学杂志,2013,23(1):55-57,83.
[3]王瀚.中青年与老年脑梗死临床特点与危险因素分析[J].河北医学,2013(1):461-463.
[4]刘庆,李永光.血尿酸与急性脑梗死相关危险因素的临床研究[J].临床与病理杂志,2014,34(1):47-48.
[5]单敏,常燕燕,赵大鹏,等.急性前循环脑梗死患者梗死体积与血清NSE水平相关性研究[J].医学信息,2018,31(10):1-3.
[6]刘树杰,贺同页,陈长青.血尿酸水平与老年急性脑梗死发病及预后之间的关系[J].中国老年学杂志,2014,8(34):4475-4476.
[7]Takayama S,Kawamoto R,Kusunoki T,et al.Uric acid is an independent risk factor for carotid atherosclerosis in a Japaneseelderly population without metabolic syndrome[J].CardiovascDiabetol,2012,1(11):452-458.
[8]Longo-Mbenza B,Luila EL,Mbete P,et al.Is hyperuricemia arisk factor of stroke and coronary heart disease among Africans?[J].Int J Cardiol,2014,71(1):17-22.
[9]李江涛,秦志红,李佩宏.血尿酸水平与脑梗死的相关性分析[J].实用中西医结合临床,2013,13(2):81-82.
[10]陈雁斌.血清尿酸水平与急性脑硬死病情程度的关联性研究[J].中国实用神经疾病杂志,2014,17(9):84-85.
[11]Vigna GB,Bolzan M,Romagnoni F,et al.Lipids and other risk factors selected by discriminant analysis in symptomatic pa-tients with supraaortic and peripheral atherosclerosis[J].Circula-tion,1992,85(6):2205-2211.
[12]王荣,薛恒,焦岩,等.中青年急性脑梗死患者血尿酸水平的相关研究[J].中国实用神经疾病杂志,2014,17(19):52-53.
[13]杨燕,张临洪,熊莉君,等.中年脑梗死患者高尿酸血症与复发的关系[J].疑难病杂志,2014,13(7):674-675.
[2]田野,车玉琴.中青年与老年缺血性卒中患者危险因素的对比研究[J].中国血液流变学杂志,2013,23(1):55-57,83.
[3]王瀚.中青年与老年脑梗死临床特点与危险因素分析[J].河北医学,2013(1):461-463.
[4]刘庆,李永光.血尿酸与急性脑梗死相关危险因素的临床研究[J].临床与病理杂志,2014,34(1):47-48.
[5]单敏,常燕燕,赵大鹏,等.急性前循环脑梗死患者梗死体积与血清NSE水平相关性研究[J].医学信息,2018,31(10):1-3.
[6]刘树杰,贺同页,陈长青.血尿酸水平与老年急性脑梗死发病及预后之间的关系[J].中国老年学杂志,2014,8(34):4475-4476.
[7]Takayama S,Kawamoto R,Kusunoki T,et al.Uric acid is an independent risk factor for carotid atherosclerosis in a Japaneseelderly population without metabolic syndrome[J].CardiovascDiabetol,2012,1(11):452-458.
[8]Longo-Mbenza B,Luila EL,Mbete P,et al.Is hyperuricemia arisk factor of stroke and coronary heart disease among Africans?[J].Int J Cardiol,2014,71(1):17-22.
[9]李江涛,秦志红,李佩宏.血尿酸水平与脑梗死的相关性分析[J].实用中西医结合临床,2013,13(2):81-82.
[10]陈雁斌.血清尿酸水平与急性脑硬死病情程度的关联性研究[J].中国实用神经疾病杂志,2014,17(9):84-85.
[11]Vigna GB,Bolzan M,Romagnoni F,et al.Lipids and other risk factors selected by discriminant analysis in symptomatic pa-tients with supraaortic and peripheral atherosclerosis[J].Circula-tion,1992,85(6):2205-2211.
[12]王荣,薛恒,焦岩,等.中青年急性脑梗死患者血尿酸水平的相关研究[J].中国实用神经疾病杂志,2014,17(19):52-53.
[13]杨燕,张临洪,熊莉君,等.中年脑梗死患者高尿酸血症与复发的关系[J].疑难病杂志,2014,13(7):674-675.