参麦注射液联合射频消融对肝癌微血管密度及血管内皮生长因子影响
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摘要
[目的]分析参麦注射液联合射频消融应用在肝癌中的治疗效果及临床应用价值。[方法]回顾性选取2016年1月～2017年12月我院治疗的肝癌患者150例,按照治疗方法不同分为观察组和对照组,对照组采取射频消融治疗,观察组联合参麦注射液治疗,对比2组临床治疗效果。[结果]观察组总有效率为46.67%,对照组总有效率为22.67%,组间对比差异有统计学意义(P<0.05)。观察组干预后微血管密度(28.57±1.51),血管内皮生长因子(278.38±17.58);对照组干预后微血管密度(33.28±2.42),血管内皮生长因子(355.84±32.52),组间对比差异有统计学意义(P<0.05)。观察组干预后疼痛评分(2.11±1.04)分,AFP(88.12±11.38)μg/ml;对照组干预后疼痛评分(3.52±1.54)分,AFP(176.85±22.07)μg/ml,组间对比差异有统计学意义(P<0.05)。[结论]参麦注射液联合射频消融应用在肝癌中可以提升治疗效果,抑制新生血管形成,减轻患者疼痛症状,值得在临床推广应用。
[Objective]To analyze the therapeutic effect and clinical value of shenmai injection combined with radiofrequency ablation in hepatocellular carcinoma.[Methods]Retrospective selection between January 2016 and December 2016,our hospital treatment of 150 cases of patients with liver cancer,according to the treatment method is divided into observation group and control group,control group treated with radiofrequency ablation,observation group joint injection treatment,compared two groups of clinical therapeutic effect.[Results]The total effective rate of the observation group was 46.67%,the total effective rate of the control group was 22.67%,and the difference between the groups was statistically significant(P<0.05).The microvascular density(28.57±1.51)and vascular endothelial growth factor(278.38±17.58)were observed in the observation group.In the control group,the microvascular density(33.28±2.42)and vascular endothelial growth factor(355.84±32.52)were statistically significant(P<0.05).After the intervention of the observation group,the pain score(2.11±1.04)was observed,and the AFP(88.12±11.38)was usedas a g/ml.In the control group,the pain score(3.52±1.54)was observed,and the AFP(176.85±22.07)was used in g/ml,and the difference between the groups was statistically significant(P <0.05).[Conclusion]The combined radiofrequency ablation of shenmai injection can improve the therapeutic effect in hepatocellular carcinoma,inhibit the formation of angiogenesis,relieve the pain symptoms of patients,and be worthy of clinical application.
[Objective]To analyze the therapeutic effect and clinical value of shenmai injection combined with radiofrequency ablation in hepatocellular carcinoma.[Methods]Retrospective selection between January 2016 and December 2016,our hospital treatment of 150 cases of patients with liver cancer,according to the treatment method is divided into observation group and control group,control group treated with radiofrequency ablation,observation group joint injection treatment,compared two groups of clinical therapeutic effect.[Results]The total effective rate of the observation group was 46.67%,the total effective rate of the control group was 22.67%,and the difference between the groups was statistically significant(P<0.05).The microvascular density(28.57±1.51)and vascular endothelial growth factor(278.38±17.58)were observed in the observation group.In the control group,the microvascular density(33.28±2.42)and vascular endothelial growth factor(355.84±32.52)were statistically significant(P<0.05).After the intervention of the observation group,the pain score(2.11±1.04)was observed,and the AFP(88.12±11.38)was usedas a g/ml.In the control group,the pain score(3.52±1.54)was observed,and the AFP(176.85±22.07)was used in g/ml,and the difference between the groups was statistically significant(P <0.05).[Conclusion]The combined radiofrequency ablation of shenmai injection can improve the therapeutic effect in hepatocellular carcinoma,inhibit the formation of angiogenesis,relieve the pain symptoms of patients,and be worthy of clinical application.
引文
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[6]王兰荣,王钖,曹旸,等.阿帕替尼联合动脉栓塞介入治疗肝癌的效果及对血管内皮生长因子和凋亡相关因子的影响[J].国际医药卫生导报,2017,23(7):1015-1017.
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[8]李燕,贾勋超,张希.鸦胆子油口服乳液联合肝动脉栓塞化疗治疗肝癌临床疗效以及对患者血浆内毒素及血管内皮生长因子水平影响研究[J].陕西医学杂志,2016,45(7):892-893.
[9]王任翔,黄崇亚.索拉菲尼联合射频消融治疗早期小肝癌的临床效果及相关机制探讨[J].中国临床医生杂志,2017,45(9):67-69.
[10]丰俊东,罗威,秦叔逵,等.剂量与时间因素对重组人血管内皮抑素联合放疗抑制小鼠肝癌移植瘤协同作用的影响[J].临床肿瘤学杂志,2017,22(4):289-297.
[11]郑侠,高舒,华海清,等.人参皂苷Rg3联合索拉非尼对裸鼠肝癌移植瘤生长和血管生成的调控作用[J].世界华人消化杂志,2016,14(5):670-677.
[12]李宁,苏芳,宁海丹,等.沙利度胺联合达那唑对子宫内膜异位症裸鼠异位组织血管生成及血管内皮生长因子的影响[J].广西医学,2016,38(9):1207-1210.
[13]李新彦,LIXin-yan.肝癌超声血流特点与微血管密度及血管内皮细胞生长因子的相关性研究[J].中国医学装备,2016,13(5):83-87.
[14]符黄德,罗起胜,邓元央,等.肝癌衍生生长因子和血管内皮生长因子在脑胶质瘤中的表达及其与肿瘤微血管密度的相关性研究[J].中国全科医学,2016,19(17):2019-2023.
[15]马英,孙韬,李玉苓,等.原发性肝癌TACE术后射频消融联合生物治疗对免疫功能及血管内皮生长因子的影响研究[J].河北医药,2016,38(12):1828-1832.
[2]王进,李森,张友朋,等.丹参酮ⅡA对人膀胱癌裸鼠移植瘤微血管密度、碱性成纤维细胞生长因子、血管内皮生长因子表达的影响[J].中华实验外科杂志,2016,33(5):1275-1277.
[3]克尤木·阿不来提,周应恩,布瓦扎尔·沙吾提.鸦胆子油乳剂辅助经导管肝动脉化疗栓塞术治疗肝癌患者临床疗效及对血浆内毒素、血管内皮生长因子水平影响[J].临床军医杂志,2017,45(8):851-853.
[4]高亭,蒋引娣,刘小伟,等.羟基红花黄色素A对Lewis肺癌移植瘤微血管密度及血管内皮生长因子mRNA表达的影响[J].中国呼吸与危重监护杂志,2016,18(5):461-464.
[5]李书征.十全大补汤对小鼠原发性肝癌的生长及血管生成的影响[J].当代医学,2016,22(25):3-5.
[6]王兰荣,王钖,曹旸,等.阿帕替尼联合动脉栓塞介入治疗肝癌的效果及对血管内皮生长因子和凋亡相关因子的影响[J].国际医药卫生导报,2017,23(7):1015-1017.
[7]梁慧,杨春,曾伟,等.肠复方对裸鼠肠癌微血管密度及血管内皮生长因子的影响[J].现代中西医结合杂志,2016,25(15):1604-1607.
[8]李燕,贾勋超,张希.鸦胆子油口服乳液联合肝动脉栓塞化疗治疗肝癌临床疗效以及对患者血浆内毒素及血管内皮生长因子水平影响研究[J].陕西医学杂志,2016,45(7):892-893.
[9]王任翔,黄崇亚.索拉菲尼联合射频消融治疗早期小肝癌的临床效果及相关机制探讨[J].中国临床医生杂志,2017,45(9):67-69.
[10]丰俊东,罗威,秦叔逵,等.剂量与时间因素对重组人血管内皮抑素联合放疗抑制小鼠肝癌移植瘤协同作用的影响[J].临床肿瘤学杂志,2017,22(4):289-297.
[11]郑侠,高舒,华海清,等.人参皂苷Rg3联合索拉非尼对裸鼠肝癌移植瘤生长和血管生成的调控作用[J].世界华人消化杂志,2016,14(5):670-677.
[12]李宁,苏芳,宁海丹,等.沙利度胺联合达那唑对子宫内膜异位症裸鼠异位组织血管生成及血管内皮生长因子的影响[J].广西医学,2016,38(9):1207-1210.
[13]李新彦,LIXin-yan.肝癌超声血流特点与微血管密度及血管内皮细胞生长因子的相关性研究[J].中国医学装备,2016,13(5):83-87.
[14]符黄德,罗起胜,邓元央,等.肝癌衍生生长因子和血管内皮生长因子在脑胶质瘤中的表达及其与肿瘤微血管密度的相关性研究[J].中国全科医学,2016,19(17):2019-2023.
[15]马英,孙韬,李玉苓,等.原发性肝癌TACE术后射频消融联合生物治疗对免疫功能及血管内皮生长因子的影响研究[J].河北医药,2016,38(12):1828-1832.