冠心病患者血管内皮细胞生长因子水平与幽门螺杆菌感染情况的关系
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摘要
目的研究冠状动脉粥样硬化性心脏病(冠心病)患者血清中血管内皮细胞生长因子(VEGF)水平与幽门螺杆菌(Hp)感染情况的关系。方法选取郑州大学第一附属医院心内科于2017年9月至11月收治的80例冠心病患者及同期80名健康体检者作为研究对象,将其分为研究组和对照组,对比两组的VEGF水平和Hp感染情况。结果研究组的Hp-IgG阳性率>对照组,阴性率低于对照组(P<0.05);研究组的Hp-IgG检测阳性血清VEGF水平和Hp-IgG检测阴性血清VEGF水平均高于对照组(P<0.05)。结论冠心病患者血清VEGF水平与Hp感染情况具有密切的关系,冠心病患者的血清VEGF水平与Hp感染几率均高于正常人群,通过对VEGF水平与Hp-IgG进行检测,能够对冠心病的病情诊断及发展提供相关检测指标,对冠心病治疗具有积极的意义。
Objective To study the relationship between serum levels of vascular endothelial growth factor(VEGF) and Helicobacter pylori(Hp) infection in patients with coronary heart disease(CHD). Methods Eighty patients with coronary heart disease admitted to the Department of Cardiology, the First Affiliated Hospital of Zhengzhou University from September 2017 to November 2017, and 80 healthy physical examination subjects were selected as study subjects. They were divided into study group and control group. VEGF levels and Hp infection were compared between the two groups. Results The positive rate of Hp-IgG in the study group was significantly higher than that in the control group, and the negative rate was significantly lower than that of the control group(P<0.05). And the level of VEGF positive serum and the negative serum VEGF level of Hp-IgG detected in the study group were significantly higher than those in the control group(P<0.05). Conclusion The serum VEGF level of patients with coronary heart disease is closely related to the Hp infection. The serum VEGF level and the Hp infection rate of the patients with coronary heart disease are higher than those of the normal population. The detection of the VEGF level and the HpIgG can provide the related detection indexes for the diagnosis and development of the coronary heart disease, and it is positive for the treatment of coronary heart disease. The meaning of it.
Objective To study the relationship between serum levels of vascular endothelial growth factor(VEGF) and Helicobacter pylori(Hp) infection in patients with coronary heart disease(CHD). Methods Eighty patients with coronary heart disease admitted to the Department of Cardiology, the First Affiliated Hospital of Zhengzhou University from September 2017 to November 2017, and 80 healthy physical examination subjects were selected as study subjects. They were divided into study group and control group. VEGF levels and Hp infection were compared between the two groups. Results The positive rate of Hp-IgG in the study group was significantly higher than that in the control group, and the negative rate was significantly lower than that of the control group(P<0.05). And the level of VEGF positive serum and the negative serum VEGF level of Hp-IgG detected in the study group were significantly higher than those in the control group(P<0.05). Conclusion The serum VEGF level of patients with coronary heart disease is closely related to the Hp infection. The serum VEGF level and the Hp infection rate of the patients with coronary heart disease are higher than those of the normal population. The detection of the VEGF level and the HpIgG can provide the related detection indexes for the diagnosis and development of the coronary heart disease, and it is positive for the treatment of coronary heart disease. The meaning of it.
引文
[1]陈雷,张旗,祝黎东,等.冠心病患者血清中血管内皮细胞生长因子水平与幽门螺杆菌抗体相关性研究[J].中国微生态学杂志,2016,28(1):54-5.
[2]张智亮,唐艳,王梦洪,等.冠心病患者血清核转录因子κB与幽门螺杆菌感染的关系[J].山东医药,2016,56(34):53-4.
[3]高荣华,张韶辉.冠心病患者冠状动脉病变与免疫细胞的相关研究[J].中国循证心血管医学杂志,2017,9(6):727-9.
[4]徐春红,沈丽萍,吉春风.幽门螺杆菌感染对冠心病患者血清hs-CRP水平及其疾病进展的影响[J].标记免疫分析与临床,2016,23(8):867-9.
[5]刘平,霍建华,白玲,等.TG/HDL-C和HDL-C对不同体型冠心病患者的诊断价值[J].中国循证心血管医学杂志,2017,9(9):1037-9.
[6]孙晓臣,洪斌,汪自龙,等.抗幽门螺杆菌治疗对CHD心绞痛患者的疗效及血脂的影响研究[J].中国医疗设备,2016,14(s1):122-5.
[7]张鹏,钟诚,李佩.冠心病患者幽门螺杆菌感染与血清中氧化低密度脂蛋白水平及冠状动脉病变严重程度的相关性研究[J].实用临床医药杂志,2017,21(5):15-7.
[8]李喆,王亚萍,孟航.冠心病患者幽门螺杆菌感染的发生状况及其与血脂代谢的关系[J].中国心血管病研究,2017,15(4):339-42.
[9]李喆,王亚萍,孟航.冠心病病人HP感染的发生状况及其与血脂代谢的关系[J].中国心血管病研究,2017,15(4):116-9.
[10]褚爱娟,楼亚玲,翁丹丹.冠心病患者幽门螺杆菌感染与血清Ghrelin、同型半胱氨酸水平的相关性研究[J].中国微生态学杂志,2016,28(3):309-11.
[11]孙慧韦,阎蓉,林靓.幽门螺杆菌感染与冠心病患者血清指标的相关性分析[J].中国卫生检验杂志,2017,16(11):1577-9.
[12]刘宁宁,周利红,孙筱婷,等.健脾解毒方通过PTEN/PI3K/AKT信号通路抑制幽门螺杆菌诱导胃癌血管新生的研究[J].中华中医药杂志,2018,10(3):1052-6.
[13]马一铭,李丽,郭涛,等.体外心脏震波对冠心病患者外周血内皮祖细胞、血管内皮生长因子和IL-8的影响及疗效评价[J].医学研究生学报,2017,30(1):42-7.
[14]潘伟琦,胡荣,芦燕玲.幽门螺杆菌现症及既往感染与心脑血管疾病的关系[J].中国医药,2014,9(6):805-7.
[15]刘晨晨,李稳,汲书生.幽门螺杆菌感染与冠心病关系的研究进展[J].山东医药,2017,57(24):106-8.
[16]刘慧,李海剑,高传玉,等.替米沙坦联合瑞舒伐他汀对2型糖尿病合并冠心病患者肝细胞生长因子和过氧化物酶体增殖物激活受体γ的影响[J].中国糖尿病杂志,2016,24(4):335-8.
[17]邓立菊,刘庆,白焱,等.冠心病患者外周血单个核细胞EPC百分比及SDF-1、VEGF-2水平变化及意义[J].山东医药,2017,57(12):77-9.
[18]于汶,宗力群,胡荣,等.幽门螺杆菌感染与颈动脉斑块及心血管病危险因素的关系[J].中国医药,2016,11(10):1442-6.
[19]刘雯辉,刘韵,张喆,等.血清成纤维细胞生长因子21水平与冠心病的病例对照研究[J].实用医学杂志,2018,12(2):199-201.
[20]陈晶,刘明,晁艳茹,等.幽门螺杆菌感染对冠心病患者相关炎性因子的影响分析[J].中华医院感染学杂志,2016,26(15):3414-6.
[21]井立省,王德昭,邹爱春,等.幽门螺杆菌和血浆血红素加氧酶1与冠心病的相关性[J].中国动脉硬化杂志,2016,24(11):1133-7.
[22]陈晶,付娟,刘娜,等.幽门螺杆菌感染对冠心病患者相关指标及颈动脉硬化的影响[J].中华医院感染学杂志,2016,26(13):2972-4.
[2]张智亮,唐艳,王梦洪,等.冠心病患者血清核转录因子κB与幽门螺杆菌感染的关系[J].山东医药,2016,56(34):53-4.
[3]高荣华,张韶辉.冠心病患者冠状动脉病变与免疫细胞的相关研究[J].中国循证心血管医学杂志,2017,9(6):727-9.
[4]徐春红,沈丽萍,吉春风.幽门螺杆菌感染对冠心病患者血清hs-CRP水平及其疾病进展的影响[J].标记免疫分析与临床,2016,23(8):867-9.
[5]刘平,霍建华,白玲,等.TG/HDL-C和HDL-C对不同体型冠心病患者的诊断价值[J].中国循证心血管医学杂志,2017,9(9):1037-9.
[6]孙晓臣,洪斌,汪自龙,等.抗幽门螺杆菌治疗对CHD心绞痛患者的疗效及血脂的影响研究[J].中国医疗设备,2016,14(s1):122-5.
[7]张鹏,钟诚,李佩.冠心病患者幽门螺杆菌感染与血清中氧化低密度脂蛋白水平及冠状动脉病变严重程度的相关性研究[J].实用临床医药杂志,2017,21(5):15-7.
[8]李喆,王亚萍,孟航.冠心病患者幽门螺杆菌感染的发生状况及其与血脂代谢的关系[J].中国心血管病研究,2017,15(4):339-42.
[9]李喆,王亚萍,孟航.冠心病病人HP感染的发生状况及其与血脂代谢的关系[J].中国心血管病研究,2017,15(4):116-9.
[10]褚爱娟,楼亚玲,翁丹丹.冠心病患者幽门螺杆菌感染与血清Ghrelin、同型半胱氨酸水平的相关性研究[J].中国微生态学杂志,2016,28(3):309-11.
[11]孙慧韦,阎蓉,林靓.幽门螺杆菌感染与冠心病患者血清指标的相关性分析[J].中国卫生检验杂志,2017,16(11):1577-9.
[12]刘宁宁,周利红,孙筱婷,等.健脾解毒方通过PTEN/PI3K/AKT信号通路抑制幽门螺杆菌诱导胃癌血管新生的研究[J].中华中医药杂志,2018,10(3):1052-6.
[13]马一铭,李丽,郭涛,等.体外心脏震波对冠心病患者外周血内皮祖细胞、血管内皮生长因子和IL-8的影响及疗效评价[J].医学研究生学报,2017,30(1):42-7.
[14]潘伟琦,胡荣,芦燕玲.幽门螺杆菌现症及既往感染与心脑血管疾病的关系[J].中国医药,2014,9(6):805-7.
[15]刘晨晨,李稳,汲书生.幽门螺杆菌感染与冠心病关系的研究进展[J].山东医药,2017,57(24):106-8.
[16]刘慧,李海剑,高传玉,等.替米沙坦联合瑞舒伐他汀对2型糖尿病合并冠心病患者肝细胞生长因子和过氧化物酶体增殖物激活受体γ的影响[J].中国糖尿病杂志,2016,24(4):335-8.
[17]邓立菊,刘庆,白焱,等.冠心病患者外周血单个核细胞EPC百分比及SDF-1、VEGF-2水平变化及意义[J].山东医药,2017,57(12):77-9.
[18]于汶,宗力群,胡荣,等.幽门螺杆菌感染与颈动脉斑块及心血管病危险因素的关系[J].中国医药,2016,11(10):1442-6.
[19]刘雯辉,刘韵,张喆,等.血清成纤维细胞生长因子21水平与冠心病的病例对照研究[J].实用医学杂志,2018,12(2):199-201.
[20]陈晶,刘明,晁艳茹,等.幽门螺杆菌感染对冠心病患者相关炎性因子的影响分析[J].中华医院感染学杂志,2016,26(15):3414-6.
[21]井立省,王德昭,邹爱春,等.幽门螺杆菌和血浆血红素加氧酶1与冠心病的相关性[J].中国动脉硬化杂志,2016,24(11):1133-7.
[22]陈晶,付娟,刘娜,等.幽门螺杆菌感染对冠心病患者相关指标及颈动脉硬化的影响[J].中华医院感染学杂志,2016,26(13):2972-4.