血必净联合碱性成纤维细胞生长因子治疗Ⅱ、Ⅲ度烧伤残余创面的临床研究
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摘要
目的分析探究血必净联合碱性成纤维细胞生长因子对Ⅱ、Ⅲ度烧伤残余创面的治疗效果。方法选择我院烧伤科2015年4月至2018年4月,3年内收治的Ⅱ、Ⅲ度烧伤患者40例作为研究对象。将其按照治疗方法的不同分为对照组(20例,仅给予碱性成纤维细胞生长因子治疗)和观察组(20例,给予血必净联合碱性成纤维细胞生长因子治疗),对两组患者治疗效果、创面愈合时间、视觉模拟评分(VAS)及焦虑自评量表(SAS)评分,进行分析比较。结果相较于对照组,观察组的治疗总有效率明显更高,创面愈合时间明显更短,VAS及SAS评分均明显降低,差异均有统计学意义(P<0.05)。结论血必净联合碱性成纤维细胞生长因子治疗Ⅱ、Ⅲ度烧伤残余创面具有明显更佳的治疗效果,能够有效地提高细菌清除率,缩短创面愈合时间,同时也减少了患者的治疗费用,更好地改善患者的生活质量,具有较高的临床实用价值。
Objective To analyze the therapeutic effect of Xuebijing combined with basic fibroblast growth factor on residual burn wounds of Ⅱ and Ⅲ burns. Methods A total of 40 patients with grade Ⅱ and Ⅲ burns admitted to our hospital from April 2015 to April 2018 were enrolled. According to the different treatment methods, they were divided into control group(20 cases, only basic fibroblast growth factor treatment) and observation group(20 cases, given Xuebijing combined with basic fibroblast growth factor treatment), two The treatment effect, wound healing time, visual analog scale(VAS) and anxiety self-rating scale(SAS) scores were analyzed and compared. Results Compared with the control group, the total effective rate of the observation group was significantly higher, the wound healing time was significantly shorter, and the VAS and SAS scores were significantly lower, the difference was statistically significant(P<0.05). Conclusion Xuebijing combined with basic fibroblast growth factor has obvious better therapeutic effect on Ⅱ and Ⅲ burn residual wounds, which can effectively improve bacterial clearance rate, shorten wound healing time and better improve patients' quality of life, it has a high clinical practical value.
Objective To analyze the therapeutic effect of Xuebijing combined with basic fibroblast growth factor on residual burn wounds of Ⅱ and Ⅲ burns. Methods A total of 40 patients with grade Ⅱ and Ⅲ burns admitted to our hospital from April 2015 to April 2018 were enrolled. According to the different treatment methods, they were divided into control group(20 cases, only basic fibroblast growth factor treatment) and observation group(20 cases, given Xuebijing combined with basic fibroblast growth factor treatment), two The treatment effect, wound healing time, visual analog scale(VAS) and anxiety self-rating scale(SAS) scores were analyzed and compared. Results Compared with the control group, the total effective rate of the observation group was significantly higher, the wound healing time was significantly shorter, and the VAS and SAS scores were significantly lower, the difference was statistically significant(P<0.05). Conclusion Xuebijing combined with basic fibroblast growth factor has obvious better therapeutic effect on Ⅱ and Ⅲ burn residual wounds, which can effectively improve bacterial clearance rate, shorten wound healing time and better improve patients' quality of life, it has a high clinical practical value.
引文
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[11]申传安,柴家科,庹晓晔,等.应用负压治疗技术修复小儿浅Ⅱ度烫伤创面的效果观察[J].实用临床护理学电子杂志,2018,29(17):14-17.
[12]李传吉.难愈性创面研究新进展与临床治疗方法[J].宁夏医学杂志,2017,39(4):289-290.
[13]汪辉,彭静,牟世伟.深Ⅱ~Ⅲ度烧伤创面病人削痂植皮联合负压创面治疗技术的回顾性分析及临床可行性研究[J].内蒙古医科大学学报,2018,40(4):85-88.
[14]孙俊锋,涂家金,罗文跃.纳米银烧伤敷料与磺胺嘧啶银乳膏治疗深Ⅱ度烧伤患者创面感染的研究[J].当代医学,2018,24(3):111-112.
[15]周丽娜,张斌杰.深Ⅱ度烧伤创面伤后不同手术时期行切削痂植皮术的临床疗效比较[J].广西医科大学学报,2018,35(9):59-62.
[2]马启海.血必净注射液联合重组牛碱性成纤维细胞生长因子凝胶治疗深度烧伤残余创面的临床研究[J].现代药物与临床,2017,32(12):2469-2472.
[3]张立彦,张利鹏,王雪芳,等.血必净注射液在毛细血管渗漏综合征治疗中的临床研究[J].国际检验医学杂志,2017,38(7):919-920.
[4]张龙,张丽香,齐旭辉,等.浸浴、磺胺嘧啶银乳膏联合复方紫草油治疗烧伤残余创面的疗效探究[J].世界临床医学,2017,11(4):113-114.
[5]Miyanaga T,Haseda Y,Daizo H,et al.A Perifascial Areolar Tissue Graft With Topical Administration of Basic Fibroblast Growth Factor for Treatment of Complex Wounds With Exposed Tendons and/or Bones[J].Journal of Foot&Ankle Surgery,2018,57(1):104-110.
[6]冯建科,邢亮,魏伟,等.血必净对重度以上烧伤切痂植皮术后患者血清C反应蛋白与降钙素原的影响[J].检验医学与临床,2018,15(11):36-38,42.
[7]陈永强,杨昌卫,朱政,等.血必净注射液对肝癌TACE术后患者缺血/再灌注损伤以及血浆内毒素的影响[J].临床医学工程,2017,24(10):1423-1424.
[8]胡卫东.莫匹罗星联合重组牛碱性成纤维细胞生长因子治疗烧伤残余创面的疗效分析[J].上海医药,2017,38(4):26-28.
[9]邹有锋.莫匹罗星与贝复济联合治疗烧伤患者残余创面并MRSA感染的效果探讨[J].医学理论与实践,2017,30(15):2267-2269.
[10]慈海,熊伟.碱性成纤维细胞生长因子联合纳米银敷料促进烧伤残余创面愈合的效果观察[J].山东医药,2017,57(26):78-80.
[11]申传安,柴家科,庹晓晔,等.应用负压治疗技术修复小儿浅Ⅱ度烫伤创面的效果观察[J].实用临床护理学电子杂志,2018,29(17):14-17.
[12]李传吉.难愈性创面研究新进展与临床治疗方法[J].宁夏医学杂志,2017,39(4):289-290.
[13]汪辉,彭静,牟世伟.深Ⅱ~Ⅲ度烧伤创面病人削痂植皮联合负压创面治疗技术的回顾性分析及临床可行性研究[J].内蒙古医科大学学报,2018,40(4):85-88.
[14]孙俊锋,涂家金,罗文跃.纳米银烧伤敷料与磺胺嘧啶银乳膏治疗深Ⅱ度烧伤患者创面感染的研究[J].当代医学,2018,24(3):111-112.
[15]周丽娜,张斌杰.深Ⅱ度烧伤创面伤后不同手术时期行切削痂植皮术的临床疗效比较[J].广西医科大学学报,2018,35(9):59-62.