桂林市在职职工高尿酸血症患病率流行病学调查及影响因素分析
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摘要
目的以灵川县为例,了解桂林市在职职工高尿酸血症的患病率以及相关影响因素。方法以2018年1月～2018年7月在本院健康体检的1 500名在职职工为研究对象,其中男性1 335人,女性165人。截取健康体检资料,分析HUA患病率,并采用多因素logistics回归分析,以OR及其95%CIs评估HUA相关影响因素。结果结果显示,受检者HUA的患病率为41.2%,其中男性患病率明显高于女性(P <0.01)。按年龄组分析显示,20～40岁HUA的患病率为43.55%,40～60岁其患病率为46.12%,60～80岁,患病率为48.85%,80岁以上患病率为49.68%,患病率随年龄增长呈增高趋势。多因素logistic回归分析显示,肥胖、高血压、高尿酸、高总胆固醇为HUA发病的危险因素,而女性、较低腹围、低血糖、高水平LDLC等为HUA的保护因素(P <0.01)。结论桂林市灵川县在职职工的HUA患病率较高,性别、肥胖、腹围、高血压、总胆固醇、低密度脂蛋白等等因素与HUA发病密切相关。
Objective To understand the prevalence rate of hyperuricemia and its related influencing factors among employees in Guilin, taking Lingchuan County as an example. Methods A total of 1500 employees who underwent physical examination in our hospital from January 2018 to July 2018 were selected as the research subjects, including 1335 males and 165 females. The health examination data were intercepted to analyze the prevalence rate of HUA. Multivariate logistics regression analysis was used to evaluate the related influencing factors of HUA with OR and 95%CIs. Results The results showed that the prevalence rate of HUA was 41.2%, and the prevalence rate of male was significantly higher than that of female(P < 0.01).According to age group analysis, the prevalence rate of HUA is 43.55% for 20-40 years old, 46.12% for 40 ～ 60 years old,48.85% for 60 ～ 80 years old and 49.68% for over 80 years old. The prevalence rate increases with age. Multivariate logistic regression analysis showed that obesity, hypertension, high uric acid and high total cholesterol were risk factors for HUA, while women, lower abdominal circumference, hypoglycemia and high level LDLC were protective factors for HUA(P < 0.01).Conclusion The prevalence rate of HUA is relatively high among employees in Lingchuan County, Guangxi, Guilin. Sex,obesity, abdominal circumference, hypertension, total cholesterol, low density lipoprotein and other factors are closely related to the incidence of HUA.
Objective To understand the prevalence rate of hyperuricemia and its related influencing factors among employees in Guilin, taking Lingchuan County as an example. Methods A total of 1500 employees who underwent physical examination in our hospital from January 2018 to July 2018 were selected as the research subjects, including 1335 males and 165 females. The health examination data were intercepted to analyze the prevalence rate of HUA. Multivariate logistics regression analysis was used to evaluate the related influencing factors of HUA with OR and 95%CIs. Results The results showed that the prevalence rate of HUA was 41.2%, and the prevalence rate of male was significantly higher than that of female(P < 0.01).According to age group analysis, the prevalence rate of HUA is 43.55% for 20-40 years old, 46.12% for 40 ～ 60 years old,48.85% for 60 ～ 80 years old and 49.68% for over 80 years old. The prevalence rate increases with age. Multivariate logistic regression analysis showed that obesity, hypertension, high uric acid and high total cholesterol were risk factors for HUA, while women, lower abdominal circumference, hypoglycemia and high level LDLC were protective factors for HUA(P < 0.01).Conclusion The prevalence rate of HUA is relatively high among employees in Lingchuan County, Guangxi, Guilin. Sex,obesity, abdominal circumference, hypertension, total cholesterol, low density lipoprotein and other factors are closely related to the incidence of HUA.
引文
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[2]黄鲁,杨彦,曾洪利,等.广州市23585名体检公务员中高尿酸血症的相关影响因素[J].贵州医科大学学报,2018,43(8):1-5.
[3]Cui L, Meng L, Wang G, et al. Prevalence and risk factors of hyperuricemia:results of the Kailuan cohort study[J]. Mod Rheumatol,2017,27(6):1066-1071.
[4]中华医学会内分泌分会.高尿酸血症和痛风治疗的中国专家的共识[C].第十二次全国内分泌学学术会议,2013,8,22-24.
[5]闫瑞.《2014成人高血压管理指南》推荐意见[J].中国循证心血管医学杂志,2013,5(6):657.
[6]美国糖尿病学会(ADA).糖尿病医学诊疗指南[J].Diabetes Care,2018,8.
[7]柳洁,于翰,胡玲,等.太原市某医疗机构11620名体检人群高尿酸血症患病情况及相关因素分析[J].中华风湿病学杂志,2011,15(3):209-212.