中药自热帖敷穴位治疗儿童哮喘缓解期的临床观察
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摘要
目的:研究中药自热帖敷穴位治疗儿童哮喘缓解期的临床疗效。方法:选取2013年2月至2014年8月广西玉林市中医医院收治的哮喘缓解期患儿86例。以随机数字表法均分为观察组与对照组。对照组予以常规西医治疗,观察组则予以中药自热贴敷穴位治疗。分别比较2组临床疗效,治疗前后各项临床症状改善情况,治疗前后免疫功能指标水平,治疗前后血清白细胞介素-13(IL-13)、巨噬细胞炎性蛋白-1α(MIP-1α)及淀粉样蛋白A(SAA)水平。结果:观察组临床总有效率为95.35%(41/43),相比对照组的69.77%(30/43)更高(P<0.05)。治疗后观察组哮喘发作程度、哮喘发作频度、反复感冒以及自汗积分分别为(1.08±0.51)分、(1.09±0.42)分、(1.08±0.71)分、(0.94±0.61)分,均明显低于对照组的(1.78±0.74)分、(1.83±0.55)分、(1.53±0.74)分、(1.44±0.70)分(均P<0.05)。治疗后观察组IgM、IgG、IgA水平分别为(1.94±0.72)mg/mL、(16.12±0.74)mg/mL、(2.32±0.47)mg/mL,均明显高于对照组的(1.62±0.57)mg/mL、(13.49±0.68)mg/mL、(1.77±0.36)mg/mL(均P<0.05)。治疗后观察组与对照组血清IL-13、MIP-1α及SAA水平均明显低于治疗前,而观察组又明显低于对照组(均P<0.05)。结论:中药自热帖敷穴位治疗儿童哮喘缓解期的临床疗效显著,有利于改善患儿临床症状,提高免疫功能,同时有效改善血清IL-13、MIP-1α及SAA水平。
Objective: To study the curative effects of traditional Chinese medicine hot compress from acupoint in the treatment of children with asthma in remission stage.Methods: From February 2013 to August 2014 in our hospital,86 cases of children with asthma in remission stage were randomly divided into experimental group and control group.The control group received conventional western medicine treatment,and the experimental group was treated with traditional Chinese medicine hot compress acupuncture treatment.The efficacy,the improvement of clinical symptoms,the immune function indexes of serum interleukin-13( IL-13),macrophage inflammatory protein1α ( MIP-1α) and serum amyloid A protein( SAA) level of two groups before and after treatment were compared.Results: The total effective rate of treatment group was 95.35%( 41/43),which was higher than the control group 69.77%( 30/43)( P < 0.05).After the treatment,degree of asthma group,the frequency of asthma attacks,repeated colds and sweating score was( 1.08 ± 0.51),( 1.09 ± 0.42).( 1.08 ± 0.71),( 0.94 ± 0.61),which were significantly lower than the control group( 1.78 ± 0.74),( 1.83 ± 0.55),( 1.53 ± 0.74),( 1.44 ± 0.70)( P < 0.05).The experimental group of IgM,IgG,IgA after treatment were( 1.94 ± 0.72) mg/mL,( 16.12 ± 0.74) mg/mL,( 2.32 ± 0.47) mg/mL,which were significantly higher than those in control group( 1.62 ± 0.57) mg/mL,( 13.49 ± 0.68) mg/mL,( 1.77 ± 0.36) mg/mL( P < 0.05).The serum IL-13,MIP-1α and SAA levels of the experimental group and the control group were significantly lower than before treatment,while the experimental group was significantly lower than the control group( P < 0.05).Conclusion: The traditional Chinese medicine hot compress acupoint in the treatment of children with asthma in remission stage showed clinical curative effect,which is beneficial to improve the clinical symptoms,improve immune function,and effectively improve the level of serum IL-13,MIP-1αand SAA.
Objective: To study the curative effects of traditional Chinese medicine hot compress from acupoint in the treatment of children with asthma in remission stage.Methods: From February 2013 to August 2014 in our hospital,86 cases of children with asthma in remission stage were randomly divided into experimental group and control group.The control group received conventional western medicine treatment,and the experimental group was treated with traditional Chinese medicine hot compress acupuncture treatment.The efficacy,the improvement of clinical symptoms,the immune function indexes of serum interleukin-13( IL-13),macrophage inflammatory protein1α ( MIP-1α) and serum amyloid A protein( SAA) level of two groups before and after treatment were compared.Results: The total effective rate of treatment group was 95.35%( 41/43),which was higher than the control group 69.77%( 30/43)( P < 0.05).After the treatment,degree of asthma group,the frequency of asthma attacks,repeated colds and sweating score was( 1.08 ± 0.51),( 1.09 ± 0.42).( 1.08 ± 0.71),( 0.94 ± 0.61),which were significantly lower than the control group( 1.78 ± 0.74),( 1.83 ± 0.55),( 1.53 ± 0.74),( 1.44 ± 0.70)( P < 0.05).The experimental group of IgM,IgG,IgA after treatment were( 1.94 ± 0.72) mg/mL,( 16.12 ± 0.74) mg/mL,( 2.32 ± 0.47) mg/mL,which were significantly higher than those in control group( 1.62 ± 0.57) mg/mL,( 13.49 ± 0.68) mg/mL,( 1.77 ± 0.36) mg/mL( P < 0.05).The serum IL-13,MIP-1α and SAA levels of the experimental group and the control group were significantly lower than before treatment,while the experimental group was significantly lower than the control group( P < 0.05).Conclusion: The traditional Chinese medicine hot compress acupoint in the treatment of children with asthma in remission stage showed clinical curative effect,which is beneficial to improve the clinical symptoms,improve immune function,and effectively improve the level of serum IL-13,MIP-1αand SAA.
引文
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[4]卢丽艳,潘磊,季辉,等.院内协定方润肺合剂治疗感染后咳嗽78例临床观察[J].实用中西医结合临床,2013,13(4):68-68.
[5]李艳静,陈竹,唐玉温,等.推拿联合护理干预防治儿童哮喘缓解期的疗效观察[J].医学信息,2016,29(32):160-160.
[6]邢乃姣,孙晓娜,王梅,等.奥氮平治疗慢性阻塞性肺病呼吸衰竭伴精神兴奋症状临床探讨[J].精神医学杂志,2016,29(6):454-455.
[7]黄晗,张向峰,卢红霞.槐杞黄颗粒防治儿童支气管哮喘的效果及其对免疫功能的影响[J].中国医药,2016,11(9):1367-1371.
[8]Tang L,Chen Q,Meng Z,et al.Suppression of Sirtuin-1 Increases IL-6 Expression by Activation of the Akt Pathway During Allergic Asthma[J].Cell Physiol Biochem,2017,43(5):1950-1960.
[9]刘芳,张新光,伍亚辉,等.健益方治疗儿童哮喘缓解期肺脾气虚证疗效观察[J].中国中西医结合儿科学,2017,09(1):1-4.
[10]裘江瑜.伏九防喘贴穴位贴敷对哮喘缓解期患儿哮喘发作频次及肺功能的影响[J].中国中医药科技,2017,24(2):237-238.
[11]孙亚锋,何增洪,张建婷,等.自拟蝉龙固本汤对哮喘缓解期患儿免疫功能的影响[J].浙江中医杂志,2017,52(8):581-581.
[12]陈怡,何维.扶正蠲哮汤内服配合中药穴位敷贴治疗小儿哮喘缓解期临床研究[J].实用中医药杂志,2013,29(1):6-7.
[13]程颖琦.王学东教授运用穴位敷贴联合中药治疗支气管哮喘经验[J].中医药通报,2013,12(2):28-30.
[14]张秋萍,朱慧志,吕园园,等.中药穴位敷贴治疗支气管哮喘缓解期研究进展[J].湖南中医杂志,2015,31(4):198-200.
[15]李华,李颉.穴位敷贴疗法分期治疗儿童哮喘缓解期的临床观察[J].河北医学,2016,22(9):1549-1550.
[16]崔华.穴位敷贴及膏方治疗小儿哮喘缓解期的临床观察[J].湖北中医杂志,2016,38(6):5-7.
[17]杨丽霞,徐玲,顾国祥,等.冬病夏治穴位敷贴法结合中药膏方治疗小儿哮喘缓解期的临床研究[J].世界中西医结合杂志,2017,12(3):403-405.
[18]魏本松,王法红.探究哮喘患者血清IL-13、VEGF、TGF-β1与气道炎症反应的相关性[J].国际医药卫生导报,2016,22(7):928-930.
[2]黄璧璇,许新连,林苑琪,等.补肾纳气汤对儿童哮喘缓解期血清Ig E、IFN-γ、IL-4水平及肺功能的影响[J].海南医学,2015,26(4):484-485.
[3]苏小慰,赵长江.儿童支气管哮喘缓解期中医药治疗进展[J].江苏中医药,2016,48(7):83-85.
[4]卢丽艳,潘磊,季辉,等.院内协定方润肺合剂治疗感染后咳嗽78例临床观察[J].实用中西医结合临床,2013,13(4):68-68.
[5]李艳静,陈竹,唐玉温,等.推拿联合护理干预防治儿童哮喘缓解期的疗效观察[J].医学信息,2016,29(32):160-160.
[6]邢乃姣,孙晓娜,王梅,等.奥氮平治疗慢性阻塞性肺病呼吸衰竭伴精神兴奋症状临床探讨[J].精神医学杂志,2016,29(6):454-455.
[7]黄晗,张向峰,卢红霞.槐杞黄颗粒防治儿童支气管哮喘的效果及其对免疫功能的影响[J].中国医药,2016,11(9):1367-1371.
[8]Tang L,Chen Q,Meng Z,et al.Suppression of Sirtuin-1 Increases IL-6 Expression by Activation of the Akt Pathway During Allergic Asthma[J].Cell Physiol Biochem,2017,43(5):1950-1960.
[9]刘芳,张新光,伍亚辉,等.健益方治疗儿童哮喘缓解期肺脾气虚证疗效观察[J].中国中西医结合儿科学,2017,09(1):1-4.
[10]裘江瑜.伏九防喘贴穴位贴敷对哮喘缓解期患儿哮喘发作频次及肺功能的影响[J].中国中医药科技,2017,24(2):237-238.
[11]孙亚锋,何增洪,张建婷,等.自拟蝉龙固本汤对哮喘缓解期患儿免疫功能的影响[J].浙江中医杂志,2017,52(8):581-581.
[12]陈怡,何维.扶正蠲哮汤内服配合中药穴位敷贴治疗小儿哮喘缓解期临床研究[J].实用中医药杂志,2013,29(1):6-7.
[13]程颖琦.王学东教授运用穴位敷贴联合中药治疗支气管哮喘经验[J].中医药通报,2013,12(2):28-30.
[14]张秋萍,朱慧志,吕园园,等.中药穴位敷贴治疗支气管哮喘缓解期研究进展[J].湖南中医杂志,2015,31(4):198-200.
[15]李华,李颉.穴位敷贴疗法分期治疗儿童哮喘缓解期的临床观察[J].河北医学,2016,22(9):1549-1550.
[16]崔华.穴位敷贴及膏方治疗小儿哮喘缓解期的临床观察[J].湖北中医杂志,2016,38(6):5-7.
[17]杨丽霞,徐玲,顾国祥,等.冬病夏治穴位敷贴法结合中药膏方治疗小儿哮喘缓解期的临床研究[J].世界中西医结合杂志,2017,12(3):403-405.
[18]魏本松,王法红.探究哮喘患者血清IL-13、VEGF、TGF-β1与气道炎症反应的相关性[J].国际医药卫生导报,2016,22(7):928-930.