~(125)I放射性粒子植入在口腔颌面部恶性肿瘤治疗中的应用
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摘要
如何提高口腔颌面部恶性肿瘤的治愈率、生存率和保持较高的生存质量,一直是学者们研究的焦点之一。彻底手术切除肿瘤组织,常会导致严重的面部畸形和功能障碍,故目前对其常采用以手术为主配合化疗或放射治疗的综合治疗方式。近年来研究结果表明,应用~(125)I放射性粒子植入的近距离放射治疗对缩小口腔颌面部恶性肿瘤的瘤体和减少复发都有较好的效果。本文对~(125)I粒子在口腔颌面部恶性肿瘤治疗中的的临床应用等方面进行总结,以期为临床提供治疗思路。
How to improve the cure rate and survival rate of oral and maxillofacial malignant tumor, and maintain a higher quality of life, have been one of the focus of the scholars study. Radical resection of oral and maxillofacial malignant tumor often leads to severe facial deformity and dysfunction, such as oral cavity, so now the chemotherapy or radiotherapy combined with surgical treatment is often used. In recent years, studies have shown that close range radiotherapy with ~(125)I radioactive seed implantation is effective in reducing tumor size and reducing recurrence of oral and maxillofacial malignant tumors. In this paper, the clinical application of ~(125)I radioactive seed in the treatment of oral and maxillofacial malignant tumors is described.
How to improve the cure rate and survival rate of oral and maxillofacial malignant tumor, and maintain a higher quality of life, have been one of the focus of the scholars study. Radical resection of oral and maxillofacial malignant tumor often leads to severe facial deformity and dysfunction, such as oral cavity, so now the chemotherapy or radiotherapy combined with surgical treatment is often used. In recent years, studies have shown that close range radiotherapy with ~(125)I radioactive seed implantation is effective in reducing tumor size and reducing recurrence of oral and maxillofacial malignant tumors. In this paper, the clinical application of ~(125)I radioactive seed in the treatment of oral and maxillofacial malignant tumors is described.
引文
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[23] Yao L,Jiang Y,Jiang P.CT-guided permanent 125I seed interstitial brachytherapy for recurrent retroperitoneal lymph node metastases after external beam radiotherapy [J].Brachytherapy,2015,14(5):662-669.
[24] Breen W,Kelly J,Park HS,et al.Permanent interstitial brachytherapy for previously irradiated head and neck cancer [J].Cureus,2018,10(4):e2517.
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[26] Rezk M,Nasr I,Ali I,et al.Comparative study between 18F FDG-PET/CT and whole body MRI DWIBS in assessment of recurrent breast cancer (prospective,comparative,cross-sectional study design) [J].Indian J Nucl Med,2019,34(1):1-9.
[27] 王兴,孟箭,顾倩平,等.PET-CT在晚期上颌骨恶性肿瘤放射性粒子植入治疗中的应用价值研究[J/CD].中华介入放射学电子杂志,2016,4(3):142-145.
[28] Kaye R,Goldstein T,Zeltsman D,et al.Three dimensional printing:A review on the utility within medicine and otolaryngology [J].Int J Pediatr Otorhinolaryngol,2016,89:145-148.
[29] Liu Y,Li H,Qin L,et al.Expert consensus workshop report:Guideline for three-dimensional printing template-assisted computed tomography-guided 125I seeds interstitial implantation brachytherapy [J].J Oral Maxillofac Surg,2017,75(7):1542-1548.
[30] 姜玉良,吉喆,郭福新,等.CT引导辅助3D打印个体化非共面模板引导125I粒子治疗头颈部复发/转移肿瘤剂量学研究[J].中华放射医学与防护杂志,2018,38(11):842-845.
[31] 姜玉良,吉喆,郭福新,等.CT引导3D打印非共面模板辅助125I粒子治疗头颈部复发转移癌不良反应研究[J].中华放射医学与防护杂志,2017,37(7):495-499.
[32] Jiang Y,Ji Z,Guo F,et al.Side effects of CT-guided implantation of 125I seeds for recurrent malignant tumors of the head and neck assisted by 3D printing non co-planar template [J].Radiat Oncol,2018,13(1):18.
[2] Georg D,Hopfgartner J,Gòra J.et al.Dosimetric considerations to determine the optimal technique for localized prostate cancer among external photon,proton,or carbon-ion therapy and high-dose-rate or low-dose-rate brachytherapyInt [J].Int J Radiat Oncol Biol Phys,2014,88(3):715-722.
[3] Tian Y,Xie Q,Tian Y,et al.Radioactive 125I seed inhibits the cell growth,migration,and invasion of nasopharyngeal carcinoma by triggering DNA damage and inactivating VEGF-A/ERK signaling [J].PLoS One,2013,8(9):e74038.
[4] Rodin J,Bar-Ad V,Cognetti D,et al.A systematic review of treating recurrent head and neck cancer:a reintroduction of brachytherapy with or without surgery [J].J Contemp Brachytherapy,2018,10(5):454-462.
[5] Liu SM,Wang HB,Sun Y,et al.The efficacy of iodine-125 permanent brachytherapy versus intensity-modulated radiation for inoperable salivary gland malignancies:study protocol of a randomised controlled trial [J].BMC Cancer,2016,16(1):193.
[6] 曹新颖,孟箭,王明玲,等.放射性粒子植入治疗晚期口腔颌面部恶性肿瘤临床效果及防辐射对策研究[J].临床军医杂志,2018,46(10):1247-1248.
[7] Palda F.Ropivacaine and bupivacaine for long-term epidural infusion in a small child [J].Br J Anaesth,1999,83(4):673.
[8] 申文江.放射性粒子植入的创新性临床研究[J].山东大学学报(医学版),2017,55(2):1-3.
[9] 李华福,谢群,叶啸,等.粒子植入近距离放射治疗与外放射治疗对局限性前列腺癌疗效比较的Meta分析[J].放射学实践,2018,33(9):950-955.
[10] Brun T,Bachaud JM,Graff-Cailleaud P,et al .New approach of ultra-focal brachytherapy for low- and intermediate-risk prostate cancer with custom-linked I-125 seeds:A feasibility study of optimal dose coverage [J].Brachytherapy,2018,17(3):544-555.
[11] Skowronek J.Current status of brachytherapy in cancer treatment-short overview [J].J Contemp Brachytherapy,2017,9(6):581-589.
[12] Gai B,Zhang F.Chinese expert consensus on radioactive 125I seeds interstitial implantation brachytherapy for pancreatic cancer [J].J Cancer Res Ther,2018,14(7):1455-1462.
[13] Vikram B,Mishra S.Permanent iodine-125 implants in postoperative radiotherapy for head and neck cancer with positive surgical margins [J].Head Neck,1994 ,16(2):155-157.
[14] Horwitz EM,Frazier AJ,Martinez AA,et al.Excellent functional outcome in patients with squamous cell carcinoma of the base of tongue treated with external irradiation and interstitial iodine 125 boost [J].Cancer,1996 ,78(5):948-957.
[15] Kestin LL,Jaffray DA ,Edmundson GK ,et al.Improving the dosimetric coverage of interstitial high-dose-rate breast implants [J].Int J Radiat Oncol Biol Phys,2000,46(1):35-43.
[16] Major T,Fodor J,Takácsi-Nagy Z,et al.Evaluation of HDR interstitial breast implants planned by conventional and optimized CT-based dosimetry systems with respect to dose homogeneity and conformality [J].Strahlenther Onkol,2005,181(2):89-96.
[17] Jiang YL,Meng N,Wang JJ,et al.CT-guided iodine-125 seed permanent implantation for recurrent head and neck cancers [J].Radiat Oncol,2010,5(1):68.
[18] Bansal A,Ghoshal S,Oinam AS,et al.High-dose-rate interstitial brachytherapy in early stage oral tongue cancer-15 year experience from a tertiary care institute [J].J Contemp Brachytherapy,2016,8(1):56-65.
[19] Ali K,Mohammad B,Marzieh L,et al.Adjuvant high-dose-rate brachytherapy in the management of oral cavity cancers:5 years of experience in Iran [J].J Contemp Brachytherapy,2017,9(4):323-329.
[20] 杨海波,黄定强,李琛.CT引导下125I放射性粒子植入治疗头颈部浅表恶性肿瘤近期疗效观察[J].中国介入影像与治疗学,2018,15(8):457-460.
[21] Tian Q,Zhu HH,Li H.Interstitial brachytherapy of oral squamous cell carcinoma with ultrasound-guided iodine-125 radioactive seed implantation [J].Eur Rev Med Pharmacol Sci,2018,22(6):1680-1685.
[22] 刘建国,钟龙,杨永杰,等.CT引导下125I粒子治疗头颈部复发恶性肿瘤近期疗效观察[J].医学临床研究,2015,32(10):1977-1980.
[23] Yao L,Jiang Y,Jiang P.CT-guided permanent 125I seed interstitial brachytherapy for recurrent retroperitoneal lymph node metastases after external beam radiotherapy [J].Brachytherapy,2015,14(5):662-669.
[24] Breen W,Kelly J,Park HS,et al.Permanent interstitial brachytherapy for previously irradiated head and neck cancer [J].Cureus,2018,10(4):e2517.
[25] 姜玉良,吉喆,田素青,等.CT引导下125I粒子挽救性治疗头颈部复发/转移癌的临床疗效[J].中华医学杂志,2018,98(45):3686-3691.
[26] Rezk M,Nasr I,Ali I,et al.Comparative study between 18F FDG-PET/CT and whole body MRI DWIBS in assessment of recurrent breast cancer (prospective,comparative,cross-sectional study design) [J].Indian J Nucl Med,2019,34(1):1-9.
[27] 王兴,孟箭,顾倩平,等.PET-CT在晚期上颌骨恶性肿瘤放射性粒子植入治疗中的应用价值研究[J/CD].中华介入放射学电子杂志,2016,4(3):142-145.
[28] Kaye R,Goldstein T,Zeltsman D,et al.Three dimensional printing:A review on the utility within medicine and otolaryngology [J].Int J Pediatr Otorhinolaryngol,2016,89:145-148.
[29] Liu Y,Li H,Qin L,et al.Expert consensus workshop report:Guideline for three-dimensional printing template-assisted computed tomography-guided 125I seeds interstitial implantation brachytherapy [J].J Oral Maxillofac Surg,2017,75(7):1542-1548.
[30] 姜玉良,吉喆,郭福新,等.CT引导辅助3D打印个体化非共面模板引导125I粒子治疗头颈部复发/转移肿瘤剂量学研究[J].中华放射医学与防护杂志,2018,38(11):842-845.
[31] 姜玉良,吉喆,郭福新,等.CT引导3D打印非共面模板辅助125I粒子治疗头颈部复发转移癌不良反应研究[J].中华放射医学与防护杂志,2017,37(7):495-499.
[32] Jiang Y,Ji Z,Guo F,et al.Side effects of CT-guided implantation of 125I seeds for recurrent malignant tumors of the head and neck assisted by 3D printing non co-planar template [J].Radiat Oncol,2018,13(1):18.