清热解毒汤联合西医治疗对手足口病(普通型)患儿血清S100B蛋白及NSE表达的影响
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摘要
目的:分析清热解毒汤联合西医治疗对普通型手足口病患儿血清S100B蛋白及神经元特异性烯醇化酶(neuron-specific enolase,NSE)表达的影响。方法 :选取我院2016年3月—2018年3月收治的普通型手足口病患儿120例,根据随机数字表法分为两组,各60例。对照组接受常规西医治疗,观察组在对照组基础上联合使用清热解毒汤(1剂/d)治疗,比较两组治疗7 d后的疗效、安全性,比较两组治疗前后血清S100B蛋白、NSE表达水平。结果 :观察组治疗效果优于对照组,差异有统计学意义(P <0.05);两组治疗期间均无不良反应发生;治疗后,观察组血清S100B、NSE水平均较对照组降低,差异有统计学意义(P <0.05)。结论 :清热解毒汤联合西医治疗小儿普通型手足口病的疗效确切,利于降低患儿血清S100B蛋白及NSE表达,安全性高。
Objective: To analyze the effect of qingre jiedu decoction combined with Western medicine treatment on serum S100 B protein and neuron-specific enolase(NSE) expressions in children with common handfoot-and-mouth diseases. Methods: 120 children with common hand-foot-and-mouth diseases admitted to our hospital from March 2016 to March 2018 were selected and randomly divided into two groups, 60 cases each. The children in the control group received conventional Western medicine treatment, and the children in the observation group were treated with qingre jiedu decoction(1 dose/d) on the basis of the control group. The efficacy and safety after 7 days of treatment were compared between the two groups, and the expressions of serum S100 B protein and NSE before and after treatment were compared between the two groups. Results: The therapeutic effect in the observation group was better than that in the control group, and the difference was statistically significant(P<0.05). There was no adverse reaction during the treatment period in the two groups. After treatment, the levels of serum S100 B and NSE in the observation group were lower than those in the control group, and the differences were statistically significant(P<0.05). Conclusion: Qingre jiedu decoction combined with Western medicine treatment is effective in the treatment of common hand-foot-and-mouth diseases in children, which is beneficial to the decrease of serum S100 B protein and NSE expressions in children, and has high safety.
Objective: To analyze the effect of qingre jiedu decoction combined with Western medicine treatment on serum S100 B protein and neuron-specific enolase(NSE) expressions in children with common handfoot-and-mouth diseases. Methods: 120 children with common hand-foot-and-mouth diseases admitted to our hospital from March 2016 to March 2018 were selected and randomly divided into two groups, 60 cases each. The children in the control group received conventional Western medicine treatment, and the children in the observation group were treated with qingre jiedu decoction(1 dose/d) on the basis of the control group. The efficacy and safety after 7 days of treatment were compared between the two groups, and the expressions of serum S100 B protein and NSE before and after treatment were compared between the two groups. Results: The therapeutic effect in the observation group was better than that in the control group, and the difference was statistically significant(P<0.05). There was no adverse reaction during the treatment period in the two groups. After treatment, the levels of serum S100 B and NSE in the observation group were lower than those in the control group, and the differences were statistically significant(P<0.05). Conclusion: Qingre jiedu decoction combined with Western medicine treatment is effective in the treatment of common hand-foot-and-mouth diseases in children, which is beneficial to the decrease of serum S100 B protein and NSE expressions in children, and has high safety.
引文
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[10]黄月艳,柳国胜,韦叶生,等.重症手足口病患儿血清S100B和NSE水平与颅脑MRI的诊断[J].中华危重病急救医学,2016,28(11):1019-1022.
[2]张稚鲲,陈仁寿.手足口病的中医药治疗进展[J].中医药信息,2017,34(6):122-126.
[3]中华人民共和国卫生部.手足口病诊疗指南(2010版)[J].中国实用乡村医生杂志,2012,19(19):9-11.
[4]汪受传,王雷,尚莉丽.中医儿科临床诊疗指南·手足口病(修订)[J].世界中医药,2016,11(4):734-740.
[5]尹红,朱磊.硫酸镁辅助治疗儿童重症手足口病的有效性及安全性分析[J].中国合理用药探索,2018,15(11):137-139.
[6]张士卿,张弢.小儿手足口病中医辨治思路之我见[J].中国中西医结合儿科学,2011,3(1):21-22.
[7]胡燕,王孟清.小儿手足口病中医证候特征及演变规律的研究[J].中国中西医结合儿科学,2011,3(1):29-32.
[8]李后宾,黄贵莲.中药解毒汤治疗手足口病60例[J].河南中医,2017,37(12):2130-2132.
[9]李晶,刘瑞海,单若冰.血清S100B蛋白和神经元特异性烯醇化酶预测手足口病严重程度的价值[J].中国当代儿科杂志,2017,19(2):182-187.
[10]黄月艳,柳国胜,韦叶生,等.重症手足口病患儿血清S100B和NSE水平与颅脑MRI的诊断[J].中华危重病急救医学,2016,28(11):1019-1022.