高危型HPV感染与宫颈癌前病变及宫颈癌的相关性研究
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摘要
目的研究宫颈病变和宫颈癌患者高危型HPV感染情况、年龄分布及亚型分布,分析高危型HPV感染与宫颈癌前病变及宫颈癌的相关性,为宫颈癌的预防筛查工作提供实验依据。方法按宫颈病变程度将313名宫颈病变患者分为CIN I、CINII、CINIII、宫颈癌4组,检测患者高危型HPV-DNA感染情况。结果 CINI组高危型HPVDNA的阳性率为16.67%,CINII组阳性率为60.38%,CINIII组阳性率为69.74%,宫颈癌组的阳性率最高,为75.42%;癌前病变(CINII-CINIII)和宫颈癌组均在41-60岁年龄区间感染率最高;癌前病变组中感染率较高的型别为HPV16(31.01%)、HPV58(14.73%)、HPV52(10.85%);宫颈癌组中感染率较高的型别依次为HPV16(47.46%),HPV18(16.69%),HPV58(11.86%),HPV52(5.93%)。结论随着宫颈病变的加重,阳性感染率也呈递增趋势;癌前病变和宫颈癌组的年龄感染高峰为41-60岁;HPV16、58、52是宫颈癌前病变的主要感染亚型;HPV16、18、58、52是宫颈癌的主要感染亚型。
Objective Research on high-risk human papillomavirus(HPV)infection in patients with cervical disease and cervical cancer,age distribution and strain distribution,analysis the correlation of high-risk HPV infection and cervical cancer disease,to provide theoretical basis for future work of cervical cancer prevention and screening.Methods According to the degree of cervical lesions,313 patients were divided into CIN I,CINⅡ,CINⅢ,and cerical cancer.Test the patients with high-risk HPV infection.Results CIN I group positive rate was 16.67%,CINⅡgroup positive rate was 60.38%,CINⅢ group positive rate was 69.74%,Cervical cancer group has the highest positive rate is 75.42%;CINⅡ group,CINⅢ group and cervical cancer group had the highest infection rates in the age of 41-60.There are 12 kinds of HPV in cervical lesions group high-risk type is checked out,the higher infection rate of type in the order were HPV16(31.01%)、HPV58(14.73%)、HPV52(10.85%).There are 12 kinds of HPV in cervical cancer group high-risk type is checked out,the higher infection rate of type in the order were HPV16(47.46%)、HPV18(16.69%)、HPV58(11.86%)、HPV52(5.93%).Conclusion As the cervical lesion is aggravating,positive rate is also increasing trend;CINⅡ,CINⅢ and cervical cancer had the peak age of 41-60 years old;H There are 12 kinds of HPV in cervical cancer group high-risk type is checked out,the higher infection rate of type in the order were HPV16(47.46%)、HPV18(16.69%)、HPV58(11.86%)、HPV52(5.93%).HPV16,58,52 are the major infection types of cervical precancerous lesions.HPV16,18,58,52 are the major infection types of cervical cancer.
Objective Research on high-risk human papillomavirus(HPV)infection in patients with cervical disease and cervical cancer,age distribution and strain distribution,analysis the correlation of high-risk HPV infection and cervical cancer disease,to provide theoretical basis for future work of cervical cancer prevention and screening.Methods According to the degree of cervical lesions,313 patients were divided into CIN I,CINⅡ,CINⅢ,and cerical cancer.Test the patients with high-risk HPV infection.Results CIN I group positive rate was 16.67%,CINⅡgroup positive rate was 60.38%,CINⅢ group positive rate was 69.74%,Cervical cancer group has the highest positive rate is 75.42%;CINⅡ group,CINⅢ group and cervical cancer group had the highest infection rates in the age of 41-60.There are 12 kinds of HPV in cervical lesions group high-risk type is checked out,the higher infection rate of type in the order were HPV16(31.01%)、HPV58(14.73%)、HPV52(10.85%).There are 12 kinds of HPV in cervical cancer group high-risk type is checked out,the higher infection rate of type in the order were HPV16(47.46%)、HPV18(16.69%)、HPV58(11.86%)、HPV52(5.93%).Conclusion As the cervical lesion is aggravating,positive rate is also increasing trend;CINⅡ,CINⅢ and cervical cancer had the peak age of 41-60 years old;H There are 12 kinds of HPV in cervical cancer group high-risk type is checked out,the higher infection rate of type in the order were HPV16(47.46%)、HPV18(16.69%)、HPV58(11.86%)、HPV52(5.93%).HPV16,58,52 are the major infection types of cervical precancerous lesions.HPV16,18,58,52 are the major infection types of cervical cancer.
引文
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[2]Ang KK,Harris J,Wheeler R,et al.Human Papillomavirus and survival of patients with oropharyngeal cancer[J].N Engl J Med,2010,363:24.
[3]Tommasion M.The human papillomavirus family and its role in carcinogene-sis[J].Semin Cancer Biol,2014,26(1):13.
[4]刘从容.HPV感染的宫颈病理学进展[J].现代妇产科进展,2011,20(5):337.
[5]徐亚萍,沈丽.高危型HPV检测在宫颈癌筛查中的应用价值[J].中外医疗杂志,2014,12(C):32.
[6]刘金凤.宫颈癌及高危型癌前病变HPV型别分布[J].中国妇幼保健,2010,25:2208.
[7]何秋玲,刘冬艳.TCT联合高危型HPV-DNA检测在宫颈病变筛查中的应用[J].中国卫生产业,2012,9(12):86.
[8]王海燕,廖雪义,余海忠,等.宫颈癌细胞中相关基因的研究概况[J].现代预防医学,2012,39(11):2693.
[9]周权,黄民主,黄霜,等.中国已婚妇女宫颈癌发病影响因素Meta分析[J].中国癌症杂志,2011,21(2):125.
[10]范洁琳.HPV感染与宫颈病变关系及相关危险因素的研究[D].湖南:中南大学湘雅三医院,2014.5.
[11]乌恩奇,赵焕虎,等.中国不同地区宫颈癌中HPV型别分布数据横向比较分析[J].中华肿瘤防治杂志,2013,20(23):1845.