固溶处理对NQZ310K生物镁合金力学与腐蚀性能的影响
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摘要
为调控心血管支架用可降解镁合金的屈强比,对具有高屈强比的挤压态生物镁合金Mg-3.0Nd-1.0Ag-0.2Zn-0.4Zr(NQZ310K)进行了固溶处理,研究了固溶温度对合金显微组织、力学性能和腐蚀性能的影响。结果表明:随着固溶处理温度的提高,晶粒逐渐长大,屈服强度降低,而抗拉强度仍然保持较高水平,屈强比明显降低,加工硬化明显;与挤压态的腐蚀性能相比,固溶处理态合金在模拟体液中的腐蚀速率随固溶温度的升高而逐渐加快,腐蚀方式由均匀腐蚀转变为点蚀。
In order to regulate the yield ratio of bio-magnesium alloy for cardiovascular stent application, the as-extruded Mg-3.0 Nd-1.0 Ag-0.2 Zn-0.4 Zr(NQZ310 K) bio-magnesium alloy with high yield ratio was treated by solution treatment, and the effects of solution temperature on microstructure, mechanical and corrosion properties of the alloy were studied. The results show that with the increase of solution treatment temperature, the grain of the alloy grows gradually, the yield strength decreases, but the ultimate tensile strength remains a high level, the yield ratio decreases obviously, and the work hardening is remarkable. Compared with the corrosion performance of the as-extruded alloy, the corrosion rate of the solution treated alloy in simulated body fluid increases with the increase of solution temperature and the corrosion mode changes from homogeneous corrosion to pitting corrosion.
In order to regulate the yield ratio of bio-magnesium alloy for cardiovascular stent application, the as-extruded Mg-3.0 Nd-1.0 Ag-0.2 Zn-0.4 Zr(NQZ310 K) bio-magnesium alloy with high yield ratio was treated by solution treatment, and the effects of solution temperature on microstructure, mechanical and corrosion properties of the alloy were studied. The results show that with the increase of solution treatment temperature, the grain of the alloy grows gradually, the yield strength decreases, but the ultimate tensile strength remains a high level, the yield ratio decreases obviously, and the work hardening is remarkable. Compared with the corrosion performance of the as-extruded alloy, the corrosion rate of the solution treated alloy in simulated body fluid increases with the increase of solution temperature and the corrosion mode changes from homogeneous corrosion to pitting corrosion.
引文
[1] 奚廷斐,魏利娜,刘婧,等.镁合金全降解血管支架研究进展[J].金属学报,2017,53(10):1153-1167.XI Ting-fei,WEI Li-na,LIU Jing,et al.Research progress in bioresorbable magnesium scaffolds[J].Acta Metallurgica Sinica,2017,53(10):1153-1167.
[2] Moravej M,Mantovani D.Biodegradable metals for cardiovascular stent application:interests and new opportunities[J].International Journal of Molecular Sciences,2011,12(7):4250-4270.
[3] Han Y L,Zhang L,Yang L X,et al.A new generation of biodegradable polymer-coated sirolimus-eluting stents for the treatment of coronary artery disease:final 5-year clinical outcomes from the CREATE study[J].Eurointervention,2012,8(7):815-822.
[4] Zhu S,Xu L,Huang N.Development of biodegradable magnesium-based biomaterials[J].Journal of Biomedical Engineering,2009,26(2):437-439.
[5] 殷俏,章晓波,王章忠,等.固溶温度对Mg-2Nd-2Gd-0.3Sr-0.2Zn-0.4Zr镁合金腐蚀性能的影响[J].材料热处理学报,2016,37(1):133-137.YIN Qiao,ZHANG Xiao-bo,WANG Zhang-zhong,et al.Effects of solution temperature on corrosion properties of Mg-2Nd-2Gd-0.3Sr-0.2Zn-0.4Zr magnesium alloy[J].Transactions of Materials and Heat Treatment,2016,37(1):133-137.
[6] 张小农,左敏超,张绍翔,等.医用可降解血管支架临床研究进展[J].金属学报,2017,53(10):1215-1226.ZHANG Xiao-nong,ZUO Min-chao,ZHANG Shao-xiang,et al.Advances in clinical research of biodegradable stents[J].Acta Metallurgica Sinica,2017,53(10):1215-1226.
[7] 袁广银,章晓波,牛佳林,等.新型可降解生物医用镁合金JDBM的研究进展[J].中国有色金属学报,2011,21(10):2476-2488.YUAN Guang-yin,ZHANG Xiao-bo,NIU Jia-lin,et al.Research progress of new type of degradable biomedical magnesium alloys JDBM[J].The Chinese Journal of Nonferrous Metals,2011,21(10):2476-2488.
[8] Haude M,Ince H,Abizaid A,et al.Safety and performance of the second- generation drug- eluting absorbable metal scaffold in patients with de- novo coronary artery lesions (BIOSOLVE- II):6 month results of a prospective,multicentre,non-randomised,first- in-man trial[J].Lancet,2016,387:31-39.
[9] Ikeo N,Nishioka M,Mukai T.Fabrication of biodegradable materials with high strength by grain refinement of Mg-0.3at%Ca alloys[J].Materials Letters,2018,223:65-68.
[10] Zhang B,Geng L,Huang L,et al.Enhanced mechanical properties in fine-grained Mg-1.0Zn-0.5Ca alloys prepared by extrusion at different temperatures[J].Scripta Materialia,2010,63:1024-1027.
[11] Zhang X,Yuan G,Niu J,et al.Microstructure,mechanical properties,biocorrosion behavior,and cytotoxicity of as-extruded Mg-Nd-Zn-Zr alloy with different extrusion ratios[J].Journal of the Mechanical Behavior of Biomedical Materials,2012,9:153-162.
[12] 白聿钦,赵丕峰,赵文波.Ag对Mg-Al-Zn系镁合金显微组织和力学性能的影响[J].铸造,2003,52(2):98-100.BAI Yu-qin,ZHAO Pi-feng,ZHAO Wen-bo.Influence of Ag on property and microstructure of magnesium alloy of Mg-Al-Zn[J].Foundry,2003,52(2):98-100.
[13] 林正捷,赵颖,张志雄,等.医用可降解镁合金抗菌性、溶血以及生物相容性的研究进展[J].稀有金属材料与工程,2018,47(1):403-408.LIN Zheng-jie,ZHAO Ying,ZHANG Zhi-xiong.et al.Antibacterial properties,hemolysis and biocompatibility of biodegradable medical magnesium alloys[J].Rare Metal Materials and Engineering,2018,47(1):403-408.
[14] Zhang X,Yuan G,Fang X,et al.Effects of solution treatment on yield ratio and biocorrosion behaviour of as-extruded Mg-2.7Nd-0.2Zn-0.4Zr alloy for cardiovascular stent application[J].Materials Technology,2013,28(3):155-158.
[15] 章晓波,毛琳,袁广银,等.心血管支架用Mg-Nd-Zn-Zr生物可降解镁合金的性能研究[J].稀有金属材料与工程,2013,42(6):1300-1305.ZHANG Xiao-bo,MAO Lin,YUAN Guang-yin,et al.Performances of biodegradable Mg-Nd-Zn-Zr magnesium alloy for cardiovascular stent[J].Rare Metal Materials and Engineering,2013,42(6):1300-1305.
[16] 刘庆.镁合金塑性变形机理研究进展[J].金属学报,2010,46(11):1458-1472.LIU Qing.Reasearch progress on plastic deformation mechanism of mg alloys[J].Acta Metallurgica Sinica,2010,46(11):1458-1472.
[17] Ben-Haroush M,Ben-Hamu G,Eliezer D,et al.The relation between microstructure and corrosion behaviour of AZ80 Mg alloy following different extrusion temperatures[J].Corrosion Science,2008,50(6):1766-1778.
[18] Azeem M,Tewari A,Mishra S,et a.Development of novel grain morphology during hot extrusion of magnesium AZ21 alloy[J].Acta Materialia,2010,58(5):1495-1502.
[19] Fei Y,Zhang X,Ba Z,et al.Effect of solution treatment on corrosion resistance of the biodegradable NZ20K alloy[J].Materials Science Forum,2016,849:196-202.
[20] 孙毅,张文鑫,许春香,等.固溶处理对Mg-Zn-Y-Zr-Ca生物镁合金组织及腐蚀性能的影响[J].材料热处理学报,2017,38(9):24-29.SUN Yi,ZHANG Wen-xin,XU Chun-xiang,et al.Effects of solution treatment on microstructure and corrosion properties of Mg-3.0Zn-0.6Y-0.5Zr-0.3Ca biological magnesium alloy[J].Transactions of Materials and Heat Treatment,2017,38(9):24-29.
[2] Moravej M,Mantovani D.Biodegradable metals for cardiovascular stent application:interests and new opportunities[J].International Journal of Molecular Sciences,2011,12(7):4250-4270.
[3] Han Y L,Zhang L,Yang L X,et al.A new generation of biodegradable polymer-coated sirolimus-eluting stents for the treatment of coronary artery disease:final 5-year clinical outcomes from the CREATE study[J].Eurointervention,2012,8(7):815-822.
[4] Zhu S,Xu L,Huang N.Development of biodegradable magnesium-based biomaterials[J].Journal of Biomedical Engineering,2009,26(2):437-439.
[5] 殷俏,章晓波,王章忠,等.固溶温度对Mg-2Nd-2Gd-0.3Sr-0.2Zn-0.4Zr镁合金腐蚀性能的影响[J].材料热处理学报,2016,37(1):133-137.YIN Qiao,ZHANG Xiao-bo,WANG Zhang-zhong,et al.Effects of solution temperature on corrosion properties of Mg-2Nd-2Gd-0.3Sr-0.2Zn-0.4Zr magnesium alloy[J].Transactions of Materials and Heat Treatment,2016,37(1):133-137.
[6] 张小农,左敏超,张绍翔,等.医用可降解血管支架临床研究进展[J].金属学报,2017,53(10):1215-1226.ZHANG Xiao-nong,ZUO Min-chao,ZHANG Shao-xiang,et al.Advances in clinical research of biodegradable stents[J].Acta Metallurgica Sinica,2017,53(10):1215-1226.
[7] 袁广银,章晓波,牛佳林,等.新型可降解生物医用镁合金JDBM的研究进展[J].中国有色金属学报,2011,21(10):2476-2488.YUAN Guang-yin,ZHANG Xiao-bo,NIU Jia-lin,et al.Research progress of new type of degradable biomedical magnesium alloys JDBM[J].The Chinese Journal of Nonferrous Metals,2011,21(10):2476-2488.
[8] Haude M,Ince H,Abizaid A,et al.Safety and performance of the second- generation drug- eluting absorbable metal scaffold in patients with de- novo coronary artery lesions (BIOSOLVE- II):6 month results of a prospective,multicentre,non-randomised,first- in-man trial[J].Lancet,2016,387:31-39.
[9] Ikeo N,Nishioka M,Mukai T.Fabrication of biodegradable materials with high strength by grain refinement of Mg-0.3at%Ca alloys[J].Materials Letters,2018,223:65-68.
[10] Zhang B,Geng L,Huang L,et al.Enhanced mechanical properties in fine-grained Mg-1.0Zn-0.5Ca alloys prepared by extrusion at different temperatures[J].Scripta Materialia,2010,63:1024-1027.
[11] Zhang X,Yuan G,Niu J,et al.Microstructure,mechanical properties,biocorrosion behavior,and cytotoxicity of as-extruded Mg-Nd-Zn-Zr alloy with different extrusion ratios[J].Journal of the Mechanical Behavior of Biomedical Materials,2012,9:153-162.
[12] 白聿钦,赵丕峰,赵文波.Ag对Mg-Al-Zn系镁合金显微组织和力学性能的影响[J].铸造,2003,52(2):98-100.BAI Yu-qin,ZHAO Pi-feng,ZHAO Wen-bo.Influence of Ag on property and microstructure of magnesium alloy of Mg-Al-Zn[J].Foundry,2003,52(2):98-100.
[13] 林正捷,赵颖,张志雄,等.医用可降解镁合金抗菌性、溶血以及生物相容性的研究进展[J].稀有金属材料与工程,2018,47(1):403-408.LIN Zheng-jie,ZHAO Ying,ZHANG Zhi-xiong.et al.Antibacterial properties,hemolysis and biocompatibility of biodegradable medical magnesium alloys[J].Rare Metal Materials and Engineering,2018,47(1):403-408.
[14] Zhang X,Yuan G,Fang X,et al.Effects of solution treatment on yield ratio and biocorrosion behaviour of as-extruded Mg-2.7Nd-0.2Zn-0.4Zr alloy for cardiovascular stent application[J].Materials Technology,2013,28(3):155-158.
[15] 章晓波,毛琳,袁广银,等.心血管支架用Mg-Nd-Zn-Zr生物可降解镁合金的性能研究[J].稀有金属材料与工程,2013,42(6):1300-1305.ZHANG Xiao-bo,MAO Lin,YUAN Guang-yin,et al.Performances of biodegradable Mg-Nd-Zn-Zr magnesium alloy for cardiovascular stent[J].Rare Metal Materials and Engineering,2013,42(6):1300-1305.
[16] 刘庆.镁合金塑性变形机理研究进展[J].金属学报,2010,46(11):1458-1472.LIU Qing.Reasearch progress on plastic deformation mechanism of mg alloys[J].Acta Metallurgica Sinica,2010,46(11):1458-1472.
[17] Ben-Haroush M,Ben-Hamu G,Eliezer D,et al.The relation between microstructure and corrosion behaviour of AZ80 Mg alloy following different extrusion temperatures[J].Corrosion Science,2008,50(6):1766-1778.
[18] Azeem M,Tewari A,Mishra S,et a.Development of novel grain morphology during hot extrusion of magnesium AZ21 alloy[J].Acta Materialia,2010,58(5):1495-1502.
[19] Fei Y,Zhang X,Ba Z,et al.Effect of solution treatment on corrosion resistance of the biodegradable NZ20K alloy[J].Materials Science Forum,2016,849:196-202.
[20] 孙毅,张文鑫,许春香,等.固溶处理对Mg-Zn-Y-Zr-Ca生物镁合金组织及腐蚀性能的影响[J].材料热处理学报,2017,38(9):24-29.SUN Yi,ZHANG Wen-xin,XU Chun-xiang,et al.Effects of solution treatment on microstructure and corrosion properties of Mg-3.0Zn-0.6Y-0.5Zr-0.3Ca biological magnesium alloy[J].Transactions of Materials and Heat Treatment,2017,38(9):24-29.