葛根素注射液联合常规西药治疗早期急性前部缺血性视神经病变的疗效及对血液流变学的影响
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摘要
目的:观察葛根素注射液联合常规西药治疗早期急性前部缺血性视神经病变(AION)的疗效及对血液流变学的影响。方法:将AION早期患者88例(88眼)根据随机数字表法分为观察组和对照组。两组患者均给予口服泼尼松、降眼压等临床常规西药治疗,观察组在对照组基础上加用中药葛根素注射液治疗。比较两组患者治疗前后最佳矫正视力(BCVA)、视野及血液流变学指标水平。结果:观察组的总有效率为84.09%,高于对照组的59.09%,差异有统计学意义(P<0.05)。两组患者治疗前视力比较,差异无统计学意义(P>0.05);治疗后观察组患者的视力改善情况优于对照组,差异有统计学意义(P<0.05)。两组患者治疗前视野平均缺损(MD)和平均敏感度(MS)、等指标比较,差异无统计学意义(P>0.05);治疗后两组患者的MD和MS较治疗前均有改善,且观察组改善程度优于对照组,差异有统计学意义(P<0.05)。治疗前两组患者间全血黏度、血浆黏度、HCT、AI水平比较,差异均无统计学意义(P>0.05);观察组患者治疗后全血黏度、血浆黏度、HCT、AI水平均较治疗前下降,差异均有统计学意义(P<0.05);对照组患者治疗后全血黏度、血浆黏度、AI水平下降差异无统计学意义(P>0.05),但HCT水平下降差异有统计学意义(P<0.05)。结论:采用葛根素注射液联合常规西药治疗能有效提高早期AION的疗效,且改善血液流变学指标水平优于单纯常规西药治疗效果。
Objective: To observe efficacy of Puerarin injection combined with conventional western medicines on patients with early acute anterior ischemic optic neuropathy(AION) and its effects on hemorheology. Methods: 88 patients(88 eyes) were randomLy divided into two groups: observation group and control group. Both groups were given conventional clinical treatment such as oral Prednisone and intraocular pressure reduction. The observation group was treated with Puerarin injection additionally. The best corrected visual acuity(BCVA), visual field and hemorheology indexes before and after the treatment were compared between the two groups. Results: The total effective rate of the observation group was 84.09%, which was higher than that of the control group(59.09%), and the difference was statistically significant(P<0.05). There was no significant difference in the visual acuity between the two groups before the treatment(P>0.05); however, after the treatment, the visual acuity improvement of the observation group was better than that of the control group after treatment, and the difference was statistically significant(P<0.05). There were no significant differences in the mean visual field defect(MD) and mean sensitivity(MS) between the two groups before the treatment(P>0.05); however, after the treatment, the MD and MS of the two groups were significantly improved, the improvement of the observation group was better than that of the control group, and the differences were statistically significant(P<0.05). There were no significant differences in whole blood viscosity, plasma viscosity, HCT and AI between the two groups before the treatment(P>0.05); however, after the treatment, the whole blood viscosity, plasma viscosity, HCT and AI levels of the observation group were lower than those before the treatment, and the differences were statistically significant(P<0.05); at the same time, except the HCT, all the other indexes of the control group were reduced, but the differences were not statistically significant(P>0.05). Conclusions: For the patients with early AION, Puerarin injection combined with conventional western medicines is superior to single western medicine in the efficacy and effects on the hemorheology indexes.
Objective: To observe efficacy of Puerarin injection combined with conventional western medicines on patients with early acute anterior ischemic optic neuropathy(AION) and its effects on hemorheology. Methods: 88 patients(88 eyes) were randomLy divided into two groups: observation group and control group. Both groups were given conventional clinical treatment such as oral Prednisone and intraocular pressure reduction. The observation group was treated with Puerarin injection additionally. The best corrected visual acuity(BCVA), visual field and hemorheology indexes before and after the treatment were compared between the two groups. Results: The total effective rate of the observation group was 84.09%, which was higher than that of the control group(59.09%), and the difference was statistically significant(P<0.05). There was no significant difference in the visual acuity between the two groups before the treatment(P>0.05); however, after the treatment, the visual acuity improvement of the observation group was better than that of the control group after treatment, and the difference was statistically significant(P<0.05). There were no significant differences in the mean visual field defect(MD) and mean sensitivity(MS) between the two groups before the treatment(P>0.05); however, after the treatment, the MD and MS of the two groups were significantly improved, the improvement of the observation group was better than that of the control group, and the differences were statistically significant(P<0.05). There were no significant differences in whole blood viscosity, plasma viscosity, HCT and AI between the two groups before the treatment(P>0.05); however, after the treatment, the whole blood viscosity, plasma viscosity, HCT and AI levels of the observation group were lower than those before the treatment, and the differences were statistically significant(P<0.05); at the same time, except the HCT, all the other indexes of the control group were reduced, but the differences were not statistically significant(P>0.05). Conclusions: For the patients with early AION, Puerarin injection combined with conventional western medicines is superior to single western medicine in the efficacy and effects on the hemorheology indexes.
引文
[1]赵堪兴,杨培增.眼科学[M]. 8版.北京:人民卫生出版社,2013:234.
[2]中华医学会眼科学分会神经眼科学组.非动脉炎性急性前部缺血性视神经病变诊断和治疗专家共识[J].中华眼科杂志,2015,51(5):323-326.
[3]王志强,马志中.外伤性视神经病变预后相关因素分析[J].中华眼底病杂志,2002,18(2):98-100.
[4]宋琛.缺血性眼病治疗新概念[M].北京:人民军医出版社,2005:154-155.
[5]刘爱琴,王爽,张丽,等.非动脉炎性前部缺血性视神经病变患者血清孕酮水平的变化田[J].眼科新进展,2016,36(5):465-467.
[6]常永业,张铭连,冯娜,等.非动脉炎性前部缺血性视神经病变患者血液流变学指标观察[J].中华眼底病杂志,2012,28(2):178-179.
[7]于晨,范华英,于慧.葛根素抗凝血作用的研究[J].时珍国医国药,2011,22(11):2663-2664.
[8]罗芝宽,刘勇,李焕明.葛根素注射液治疗冠心病心绞痛的临床疗效和安全性研究[J].中华流行病学杂志,2012,33(6):614-616.
[9]刘俞佐,李若溪.中西医结合治疗缺血性视神经病变的研究进展[J].亚太传统医药,2017,13(6):69-72.
[2]中华医学会眼科学分会神经眼科学组.非动脉炎性急性前部缺血性视神经病变诊断和治疗专家共识[J].中华眼科杂志,2015,51(5):323-326.
[3]王志强,马志中.外伤性视神经病变预后相关因素分析[J].中华眼底病杂志,2002,18(2):98-100.
[4]宋琛.缺血性眼病治疗新概念[M].北京:人民军医出版社,2005:154-155.
[5]刘爱琴,王爽,张丽,等.非动脉炎性前部缺血性视神经病变患者血清孕酮水平的变化田[J].眼科新进展,2016,36(5):465-467.
[6]常永业,张铭连,冯娜,等.非动脉炎性前部缺血性视神经病变患者血液流变学指标观察[J].中华眼底病杂志,2012,28(2):178-179.
[7]于晨,范华英,于慧.葛根素抗凝血作用的研究[J].时珍国医国药,2011,22(11):2663-2664.
[8]罗芝宽,刘勇,李焕明.葛根素注射液治疗冠心病心绞痛的临床疗效和安全性研究[J].中华流行病学杂志,2012,33(6):614-616.
[9]刘俞佐,李若溪.中西医结合治疗缺血性视神经病变的研究进展[J].亚太传统医药,2017,13(6):69-72.