暖宫七味丸联合针刺治疗子宫肌瘤临床研究
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摘要
目的:观察暖宫七味丸联合针刺疗法保守治疗子宫肌瘤的临床疗效。方法:将120例行保守治疗的子宫肌瘤患者按随机数字表法分为2组各60例。对照组采用常规西医保守治疗,观察组在对照组治疗方案的基础上给予针刺联合暖宫七味丸口服治疗。观察比较2组临床疗效、中医证候评分、血液流变学、血清炎症因子、不良反应发生率等情况。结果:临床疗效总有效率观察组88.33%,对照组73.33%,差异有统计学意义(P <0.05)。治疗后,观察组中医证侯腹部包块、带下增多、月经紊乱、面色灰暗等评分均低于对照组,血液流变学指标包括血浆黏度、红细胞聚集指数均低于对照组,血清炎症因子指标包括血管内皮生长因子(VEGF)、肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)水平均低于对照组,组间比较,差异均有统计学意义(P <0.05)。不良反应发生率观察组16.67%,对照组11.67%,组间比较,差异无统计学意义(P> 0.05)。结论:暖宫七味丸联合针刺疗法保守治疗子宫肌瘤临床疗效显著,能改善患者的中医证候,降低患者的血液流变学和血清炎症因子水平,治疗安全性好。
Objective:To observe the clinical effect of Nuangong Qiwei pills combined with acupuncture in conservative treatment for uterine fibroids. Methods: Divided 120 cases of patients with uterine fibroids who underwent conservative treatment into two groups,60 cases in each group,according to random number table. The control group was treated with routine conservative treatment in western medicine,while the observation group was additionally given acupuncture combined with the oral administration of Nuangong Qiwei pills. Compared the clinical effect, Chinese medicine syndrome scores, hemorheology, serum inflammatory factors, and the incidence of adverse reactions in the two groups. Results:The total effective rate of clinical effect was 88.33% in the observation group and 73.33% in the control group, difference being significant(P < 0.05). After treatment, the scores of Chinese medicine syndromes such as the abdominal mass,abnormal vaginal discharge,the menstrual disorder and dullness of complexion in the observation group were lower than those in the control group;the hemorheology indexes,including plasma viscosity and erythrocyte aggregation,were lower than those in the control group; the serum inflammatory factors, including vascular endothelial growth factor(VEGF), tumor necrosis factor-α(TNF-α),and interleukin-1β(IL-1β)level,were all lower than those in the control group,differences being significant(P< 0.05). The incidence of adverse reactions was 16.67% in the observation group and 11.67% in the control group, no significant difference being found in the comparison between the groups(P > 0.05). Conclusion: The application of Nuangong Qiwei pills combined with acupuncture therapy in conservative treatment for uterine fibroidshas obvious clinical effect. It can improve the Chinese medicine symptoms of patients and reduceblood rheology and serum inflammatory factor levels in patients. It has better safety in the treatment.
Objective:To observe the clinical effect of Nuangong Qiwei pills combined with acupuncture in conservative treatment for uterine fibroids. Methods: Divided 120 cases of patients with uterine fibroids who underwent conservative treatment into two groups,60 cases in each group,according to random number table. The control group was treated with routine conservative treatment in western medicine,while the observation group was additionally given acupuncture combined with the oral administration of Nuangong Qiwei pills. Compared the clinical effect, Chinese medicine syndrome scores, hemorheology, serum inflammatory factors, and the incidence of adverse reactions in the two groups. Results:The total effective rate of clinical effect was 88.33% in the observation group and 73.33% in the control group, difference being significant(P < 0.05). After treatment, the scores of Chinese medicine syndromes such as the abdominal mass,abnormal vaginal discharge,the menstrual disorder and dullness of complexion in the observation group were lower than those in the control group;the hemorheology indexes,including plasma viscosity and erythrocyte aggregation,were lower than those in the control group; the serum inflammatory factors, including vascular endothelial growth factor(VEGF), tumor necrosis factor-α(TNF-α),and interleukin-1β(IL-1β)level,were all lower than those in the control group,differences being significant(P< 0.05). The incidence of adverse reactions was 16.67% in the observation group and 11.67% in the control group, no significant difference being found in the comparison between the groups(P > 0.05). Conclusion: The application of Nuangong Qiwei pills combined with acupuncture therapy in conservative treatment for uterine fibroidshas obvious clinical effect. It can improve the Chinese medicine symptoms of patients and reduceblood rheology and serum inflammatory factor levels in patients. It has better safety in the treatment.
引文
[1]王秋红,杜栩名,杜雅兰.针刺补泻配合温针刺治疗子宫肌瘤48例的临床效果评价[C]//中国医院药学杂志编辑部.中国医院药学杂志学术年会论文集,昆明:[出版者不详],2016.
[2] LIU H, ZHANG J, HAN Z Y, et al. Effectiveness of Ultrasound-guided Percutaneous Microwave Ablation for Symptomatic Uterine Fibroids:A Multicenter Study in China[J].International Journal of Hyperthermia, 2016, 32(8):876-880.
[3]子宫肌瘤的诊治中国专家共识专家组.子宫肌瘤的诊治中国专家共识[J].中华妇产科杂志,2017,52(12):793-800.
[4]赵纯.子宫肌瘤的中医辩证论治[J].南阳理工学院学报,2009,1(1):79-81.
[5]李晓岚,梁小娟,陈小宁.宫瘤消胶囊辅助米非司酮保守治疗子宫肌瘤患者的临床效果和安全性[J].临床合理用药杂志,2017,10(11):77-78.
[6] HARTMANN K E,VELEZ EDWARDS D R,SAVITZ D A,et al.Prospective Cohort Study of Uterine Fibroids and Miscarriage Risk[J].American Journal of Epidemiology,2017,186(10):1-9.
[7]达古拉.蒙药暖宫七味丸的研究进展[J].世界最新医学信息文摘,2015,23(19):122-122.
[8]康树宇.桂枝茯苓丸加减配合针灸治疗子宫肌瘤临床观察[J].中国民族民间医药,2012,21(11):96-96.
[9]赵宏艳.蒙药暖宫七味丸治疗痛经的总结[J].中国民族医药杂志,2014,20(5):20-21.
[10]包龙堂.蒙药暖宫七味丸治疗更年期综合征临床观察[J].中国保健营养,2015,25(8):116-117.
[11]孙艳红.氯米芬联合暖宫七味丸治疗不孕多囊卵巢综合征的前瞻性对照研究[J].现代医学,2016,34(4):483-487.
[12]宋长月.自拟痛经贴外敷配合口服中药治疗原发性痛经(寒凝血瘀证)的临床观察[D].长春:长春中医药大学,2016.
[13] DONNEZ J, DOLMANS M M.Uterine fibroid management:from the present to the future[J].Human Reproduction Update,2016,22(6):665-686.
[2] LIU H, ZHANG J, HAN Z Y, et al. Effectiveness of Ultrasound-guided Percutaneous Microwave Ablation for Symptomatic Uterine Fibroids:A Multicenter Study in China[J].International Journal of Hyperthermia, 2016, 32(8):876-880.
[3]子宫肌瘤的诊治中国专家共识专家组.子宫肌瘤的诊治中国专家共识[J].中华妇产科杂志,2017,52(12):793-800.
[4]赵纯.子宫肌瘤的中医辩证论治[J].南阳理工学院学报,2009,1(1):79-81.
[5]李晓岚,梁小娟,陈小宁.宫瘤消胶囊辅助米非司酮保守治疗子宫肌瘤患者的临床效果和安全性[J].临床合理用药杂志,2017,10(11):77-78.
[6] HARTMANN K E,VELEZ EDWARDS D R,SAVITZ D A,et al.Prospective Cohort Study of Uterine Fibroids and Miscarriage Risk[J].American Journal of Epidemiology,2017,186(10):1-9.
[7]达古拉.蒙药暖宫七味丸的研究进展[J].世界最新医学信息文摘,2015,23(19):122-122.
[8]康树宇.桂枝茯苓丸加减配合针灸治疗子宫肌瘤临床观察[J].中国民族民间医药,2012,21(11):96-96.
[9]赵宏艳.蒙药暖宫七味丸治疗痛经的总结[J].中国民族医药杂志,2014,20(5):20-21.
[10]包龙堂.蒙药暖宫七味丸治疗更年期综合征临床观察[J].中国保健营养,2015,25(8):116-117.
[11]孙艳红.氯米芬联合暖宫七味丸治疗不孕多囊卵巢综合征的前瞻性对照研究[J].现代医学,2016,34(4):483-487.
[12]宋长月.自拟痛经贴外敷配合口服中药治疗原发性痛经(寒凝血瘀证)的临床观察[D].长春:长春中医药大学,2016.
[13] DONNEZ J, DOLMANS M M.Uterine fibroid management:from the present to the future[J].Human Reproduction Update,2016,22(6):665-686.