老年帕金森病患者血清同型半胱氨酸及血尿酸水平与认知功能障碍的相关性分析
|
摘要
目的探究老年帕金森病患者血清同型半胱氨酸及血尿酸水平与认知功能障碍的相关性。方法选取老年帕金森病患者50例为实验组,所选时间为2017年1月至2017年12月,同时选取老年健康体检者50例为对照组,其均接受血清Hcy(同型半胱氨酸)、UA(血尿酸)水平以及认知功能的检测,对其检测的结果进行分析。结果实验组PD患者的Hcy水平明显高于对照组健康体检者,其UA水平低于对照组,差异有统计学意义(P<0.05);伴认知功能障碍的PD患者,其Hcy水平明显高于不伴认知功能障碍者,其UA水平低于不伴认知功能障碍者,差异有统计学意义(P<0.05)。结论老年帕金森病患者,其血清同型半胱氨酸以及血尿酸水平与其认知功能障碍之间有着密切的联系。
Objective To explore the correlation between serum homocysteine and uric acid levels and cognitive impairment in elderly patients with Parkinson' s disease. Methods 50 elderly patients with Parkinson's disease were selected as the experimental group from January 2017 to December 2017, and 50 healthy elderly people were selected as the control group. They were all tested for the levels of serum Hcy(homocysteine), UA(blood uric acid) and cognitive function, and the results were analyzed. Results The Hcy level of PD patients in the experimental group was significantly higher than that of the healthy persons in the control group, and the UA level was lower than that of the control group(P<0.05). The Hcy level of PD patients with cognitive impairment was significantly higher than that of those without cognitive impairment, and the UA level of PD patients with cognitive impairment was lower than that of those without cognitive impairment(P<0.05). Conclusion Serum homocysteine and uric acid levels are closely related to cognitive impairment in elderly patients with Parkinson' s disease.
Objective To explore the correlation between serum homocysteine and uric acid levels and cognitive impairment in elderly patients with Parkinson' s disease. Methods 50 elderly patients with Parkinson's disease were selected as the experimental group from January 2017 to December 2017, and 50 healthy elderly people were selected as the control group. They were all tested for the levels of serum Hcy(homocysteine), UA(blood uric acid) and cognitive function, and the results were analyzed. Results The Hcy level of PD patients in the experimental group was significantly higher than that of the healthy persons in the control group, and the UA level was lower than that of the control group(P<0.05). The Hcy level of PD patients with cognitive impairment was significantly higher than that of those without cognitive impairment, and the UA level of PD patients with cognitive impairment was lower than that of those without cognitive impairment(P<0.05). Conclusion Serum homocysteine and uric acid levels are closely related to cognitive impairment in elderly patients with Parkinson' s disease.
引文
[1]张东亚,杨改清,张晓艺,等.血清胱抑素C、同型半胱氨酸、叶酸、血尿酸水平与帕金森病认知功能障碍的相关性[J].中国老年学杂志,2017,37(3):633-635.
[2]刘婷婷,宋立友,李宏岩,等.帕金森病伴认知功能障碍与血尿酸、同型半胱氨酸相关性的研究进展[J].国际老年医学杂志,2014,35(6):276-279.
[3] Agata Rozycka, Pawel P Jagodzinski, Wojciech Kozubski, et al. Homocysteine Level and Mechanisms of Injury in Parkinson's Disease as Related to Mthfr,MTR, and Mthfd1 Genes Polymorphisms and LDopa Treatment[J]. Current genomics, 2013,14(8):534-542.
[4]张雪,臧传龙,裴海涛,等.单唾液酸四己糖神经节苷酯钠对帕金森患者轻度认知功能障碍的临床疗效分析[J].当代医学,2018,24(10):103-104.
[5]李桂花,夏欢,李沛珊,等.新疆维吾尔族及汉族帕金森病患者认知功能比较[J].中国老年学杂志,2018,38(2):460-462.
[6] Shahrizaila N, Mahamad UA, Yap AC, et al. Is chronic levodopa therapy associated with distal symmetric polyneuropathy in Parkinson's disease?[J]. Parkinsonism, related disorders, 2013,19(3):391-393.
[7]陈爱春,舒化青,肖瑞,等.帕金森病患者出现认知功能障碍的危险因素Logistic回归分析[J].中国实用神经疾病杂志,2016,19(2):82-83.
[8]林亚琴,姜河,陈祥华,等.同型半胱氨酸(Hcy)水平与帕金森病(PD)伴发抑郁症状之间的关系[J].当代医学,2018,24(20):155-157.
[9]李周玲,吕雄胜.血尿酸、同型半胱氨酸在帕金森患者认知功能障碍中的临床意义[J].现代实用医学,2017,29(8):1018-1019.
[2]刘婷婷,宋立友,李宏岩,等.帕金森病伴认知功能障碍与血尿酸、同型半胱氨酸相关性的研究进展[J].国际老年医学杂志,2014,35(6):276-279.
[3] Agata Rozycka, Pawel P Jagodzinski, Wojciech Kozubski, et al. Homocysteine Level and Mechanisms of Injury in Parkinson's Disease as Related to Mthfr,MTR, and Mthfd1 Genes Polymorphisms and LDopa Treatment[J]. Current genomics, 2013,14(8):534-542.
[4]张雪,臧传龙,裴海涛,等.单唾液酸四己糖神经节苷酯钠对帕金森患者轻度认知功能障碍的临床疗效分析[J].当代医学,2018,24(10):103-104.
[5]李桂花,夏欢,李沛珊,等.新疆维吾尔族及汉族帕金森病患者认知功能比较[J].中国老年学杂志,2018,38(2):460-462.
[6] Shahrizaila N, Mahamad UA, Yap AC, et al. Is chronic levodopa therapy associated with distal symmetric polyneuropathy in Parkinson's disease?[J]. Parkinsonism, related disorders, 2013,19(3):391-393.
[7]陈爱春,舒化青,肖瑞,等.帕金森病患者出现认知功能障碍的危险因素Logistic回归分析[J].中国实用神经疾病杂志,2016,19(2):82-83.
[8]林亚琴,姜河,陈祥华,等.同型半胱氨酸(Hcy)水平与帕金森病(PD)伴发抑郁症状之间的关系[J].当代医学,2018,24(20):155-157.
[9]李周玲,吕雄胜.血尿酸、同型半胱氨酸在帕金森患者认知功能障碍中的临床意义[J].现代实用医学,2017,29(8):1018-1019.