新生儿急性泪囊炎治疗过程中血清超敏C-反应蛋白水平检测的临床意义
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摘要
目的探讨超敏C-反应蛋白(hs-CRP)检测在新生儿急性泪囊炎治疗过程中的临床意义。方法以本院收治的64例新生儿急性泪囊炎患儿作为研究对象,采用控制感染并及时行泪道冲洗和泪道探通法进行治疗,治疗过程中采用免疫比浊法检测患儿血清hs-CRP水平,并结合临床症状进行综合分析。结果64例患儿全部治愈。入院时患儿血清hs-CRP平均水平为(21.25±9.78)mg/L,显著高于正常参考范围的(0~8)mg/L;治疗3 d后血清hs-CRP平均水平为(13.46±4.55)mg/L,与入院时比较差异具有统计学意义(t=24.1,P<0.01);治愈后患儿血清hs-CRP平均水平为(2.60±1.88)mg/L,与治疗3 d后水平比较,差异具有统计学意义(t=19.2,P<0.01)。结论正规治疗急性泪囊炎新生患儿的同时检测其血清hs-CRP水平的变化对临床观察以及预后判断具有重要的临床意义。
Objective To investigate the clical significance of changes of serum hypersensitive C-reactive protein(hs-CRP) in patients with neonatal acute dacryocystitis(NAD).Methods The levels of serum hs-CRP(with immuno-turbidity) were detected in 64 patinets with NAD before treatment and treatments for 3 days and after cure.All clinical features were comprehensively analyzed.Results Total of64 children were all cured.The mean level of serum hs-CRP was(21.25 ± 9.78) mg/L on admission.It was significantly higher than the normal reference range(0-8 mg/L).After 3 days of treatment,the mean level of serum hs-CRP dropped down to(13.46 ± 4.55) mg/L,with significant difference compared with that of 3 days after treatment(t = 24.1,P < 0.01).After cure,the mean level of serum hs-CRP was(2.60± 1.88) mg/L,there were the significant difference compared with the previous level(t = 19.2,P < 0.01).Conclusions Measurement of the changes of serum hs-CRP levels in therapeutic process might be important for the outcome prediction in NAD.
Objective To investigate the clical significance of changes of serum hypersensitive C-reactive protein(hs-CRP) in patients with neonatal acute dacryocystitis(NAD).Methods The levels of serum hs-CRP(with immuno-turbidity) were detected in 64 patinets with NAD before treatment and treatments for 3 days and after cure.All clinical features were comprehensively analyzed.Results Total of64 children were all cured.The mean level of serum hs-CRP was(21.25 ± 9.78) mg/L on admission.It was significantly higher than the normal reference range(0-8 mg/L).After 3 days of treatment,the mean level of serum hs-CRP dropped down to(13.46 ± 4.55) mg/L,with significant difference compared with that of 3 days after treatment(t = 24.1,P < 0.01).After cure,the mean level of serum hs-CRP was(2.60± 1.88) mg/L,there were the significant difference compared with the previous level(t = 19.2,P < 0.01).Conclusions Measurement of the changes of serum hs-CRP levels in therapeutic process might be important for the outcome prediction in NAD.
引文
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2 Lin IS,Nar MK,Kua KE,et al.Congenital dacrypcystocele with acute dacrypcystitis:report of two cases[J].Acta Paediatr Taiwan,2006,47(1):38-42.
3肖志刚,郭燕,唐晓容.抗生素联合泪道冲洗及探通法治疗新生儿急性泪囊炎的疗效观察[J].国际眼科杂志,2009,9(4):788-789.
4林静萍.泪道探通术联合氧氟沙星凝胶填充治疗新生儿泪囊炎[J].河北联合大学学报(医学版),2013,15(2):228-229.
5李静.新生儿急性泪囊炎的治疗[J].中国医学创新,2012,9(18):38-39.
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7张宁,张春丽.双黄连行泪道冲洗结合探通术治疗泪囊炎的探讨[J].中国现代医生,2008,46(29):6-7.
8尹爱晚.婴幼儿泪囊炎的治疗及护理[J].中国现代医生2008,46(33):121,129.
9 Baskin DE,Reddy AK,Chu YI,et al.The timing of antibiotic administration in the nagement of infant dacryocystitis[J].J AAPOS,2008,12(5):456-459.
10薛青,宋颖,高彦娥,等,C-反应蛋白与白细胞计数联合检测在上呼吸道感染中的临床应用[J/CD].中华实验和临床感染病杂志:电子版,2014,8(3):356-359.
11刘罡,曾义岚,陈竹,等.179例手足口病合并神经系统损害患者的临床分析[J/CD].中华实验和临床感染病杂志:电子版,2014,8(4):510-513.
12黄鹤,马萍,武天石.C-反应蛋白与白细胞计数联合检测在儿科感染疾病中的应用[J/CD].中华实验和临床感染病杂志:电子版.2012,6(3):253-254.
13哈丽君,杨金翘,王宝珍.等.新生儿感染性疾病超敏C-反应蛋白检测及其意义[J].陕西医学杂志,2013,42(5):618-619.
14沈国森,徐致远.超敏C-反应蛋白联合白细胞检测在新生儿细菌感染性疾病中的应用价值分析[J].中国现代医生,2013,51(9):97-99.
15 Galletto-Lacou R,Zamora SA,Gervaix A.Bedside procalcitonin and C-reactive protein test in children with fever without localizing signs of infection seen in a referral center[J].Pediatrics,2002,112(5):1054-1060.
2 Lin IS,Nar MK,Kua KE,et al.Congenital dacrypcystocele with acute dacrypcystitis:report of two cases[J].Acta Paediatr Taiwan,2006,47(1):38-42.
3肖志刚,郭燕,唐晓容.抗生素联合泪道冲洗及探通法治疗新生儿急性泪囊炎的疗效观察[J].国际眼科杂志,2009,9(4):788-789.
4林静萍.泪道探通术联合氧氟沙星凝胶填充治疗新生儿泪囊炎[J].河北联合大学学报(医学版),2013,15(2):228-229.
5李静.新生儿急性泪囊炎的治疗[J].中国医学创新,2012,9(18):38-39.
6刘若琼,李慧丽,裴玉喜.新生儿泪囊炎治疗方法的探讨[J].中外医学研究,2013,11(14)101-101.
7张宁,张春丽.双黄连行泪道冲洗结合探通术治疗泪囊炎的探讨[J].中国现代医生,2008,46(29):6-7.
8尹爱晚.婴幼儿泪囊炎的治疗及护理[J].中国现代医生2008,46(33):121,129.
9 Baskin DE,Reddy AK,Chu YI,et al.The timing of antibiotic administration in the nagement of infant dacryocystitis[J].J AAPOS,2008,12(5):456-459.
10薛青,宋颖,高彦娥,等,C-反应蛋白与白细胞计数联合检测在上呼吸道感染中的临床应用[J/CD].中华实验和临床感染病杂志:电子版,2014,8(3):356-359.
11刘罡,曾义岚,陈竹,等.179例手足口病合并神经系统损害患者的临床分析[J/CD].中华实验和临床感染病杂志:电子版,2014,8(4):510-513.
12黄鹤,马萍,武天石.C-反应蛋白与白细胞计数联合检测在儿科感染疾病中的应用[J/CD].中华实验和临床感染病杂志:电子版.2012,6(3):253-254.
13哈丽君,杨金翘,王宝珍.等.新生儿感染性疾病超敏C-反应蛋白检测及其意义[J].陕西医学杂志,2013,42(5):618-619.
14沈国森,徐致远.超敏C-反应蛋白联合白细胞检测在新生儿细菌感染性疾病中的应用价值分析[J].中国现代医生,2013,51(9):97-99.
15 Galletto-Lacou R,Zamora SA,Gervaix A.Bedside procalcitonin and C-reactive protein test in children with fever without localizing signs of infection seen in a referral center[J].Pediatrics,2002,112(5):1054-1060.