中老年原发性高血压患者血管紧张素Ⅱ、醛固酮、促肾上腺皮质激素及甲状腺激素的检测结果分析
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摘要
目的:分析中老年原发性高血压患者血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)、促肾上腺皮质激素(ACTH)及甲状腺激素的检测结果。方法:214例中老年(≥45岁)原发性高血压患者(EH组)进行血浆AngⅡ、ALD、ACTH、总三碘甲状腺原氨酸(TT3)、游离三碘甲状腺原氨酸(FT3)、甲状腺素(T4)、促甲状腺激素(TSH)检测,并与同期我院的135例中老年(≥45岁)健康者(对照组)检测结果对比。结果:EH组AngⅡ、ALD、ACTH含量显著高于对照组,TT3、FT3显著低于对照组,差异具有统计学意义;两组T4和TSH差异不显著;EH组45-59岁患者AngⅡ和ALD显著低于≥60岁者,差异具有统计学意义;EH组Ⅰ级、Ⅱ级、Ⅲ级AngⅡ、ALD、ACTH水平依次显著升高,TT3和FT3依次显著降低,差异具有统计学意义;治疗后EH组AngⅡ、ALD和ACTH水平显著降低,TT3、FT3水平显著增高,差异具有统计学意义。结论:AngⅡ、ALD、ACTH和甲状腺激素可作为中老年原发性高血压患者病情程度检测和预后指标,临床诊断意义重大。
Objective To analyze the detection results of angiotensin II(Ang II), aldosterone(ALD), adrenocorticotrophic hormone(ACTH) and thyroid hormone in elderly patients with essential hypertension. Methods A total of 214 middle-agedpatients(≥45 years old) with essential hypertension(EH group) receiveddetection of Ang II, ALD, ACTH, total triiodothyronine(TT3), free triiodothyronine(FT3), thyroxine(T4) and thyroid stimulating hormone(TSH), and the results were compared with those of 135 middle-aged(≥45 years) healthy subjects(control group). Results The levels of Ang II, ALD, ACTH in EH group were significantly higher than those in control group while levels of FT3 and TT3 were significantly lower. T4 and TSH showedno significant differences between the two groups. The levels of Ang II and ALD in patients aged 45-59 years old were significantly lower than those in patients ≥ 60 years old in RH group. The levels of Ang II, ALD and ACTHsignificantly increased successively from grade I, II to III in EH group while FT3 and TT3 significantly decreased successively. After treatment, the levels of Ang II, ALD and ACTH in EH group were significantly decreased, and the levels of FT3 and TT3 were significantly increased. Conclusion Ang II, ALD, ACTH and thyroid hormones can be used as the indicators for detecting the severity of essential hypertension and prognosis in middle-aged patients.
Objective To analyze the detection results of angiotensin II(Ang II), aldosterone(ALD), adrenocorticotrophic hormone(ACTH) and thyroid hormone in elderly patients with essential hypertension. Methods A total of 214 middle-agedpatients(≥45 years old) with essential hypertension(EH group) receiveddetection of Ang II, ALD, ACTH, total triiodothyronine(TT3), free triiodothyronine(FT3), thyroxine(T4) and thyroid stimulating hormone(TSH), and the results were compared with those of 135 middle-aged(≥45 years) healthy subjects(control group). Results The levels of Ang II, ALD, ACTH in EH group were significantly higher than those in control group while levels of FT3 and TT3 were significantly lower. T4 and TSH showedno significant differences between the two groups. The levels of Ang II and ALD in patients aged 45-59 years old were significantly lower than those in patients ≥ 60 years old in RH group. The levels of Ang II, ALD and ACTHsignificantly increased successively from grade I, II to III in EH group while FT3 and TT3 significantly decreased successively. After treatment, the levels of Ang II, ALD and ACTH in EH group were significantly decreased, and the levels of FT3 and TT3 were significantly increased. Conclusion Ang II, ALD, ACTH and thyroid hormones can be used as the indicators for detecting the severity of essential hypertension and prognosis in middle-aged patients.
引文
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[17]李朝金,张丽.高血压五联检在高血压患者中的应用价值研究[J].医学与社会,2015,28(B05):70-70.
[18]王静,郭金昊,季倩倩,等.中老年原发性高血压病人血压晨峰现象分析[J].中西医结合心脑血管病杂志,2016,14(13):1508-1509.
[19]黄雨晴,冯颖青,陈纪言,等.中老年原发性高血压患者脉压指数与颈动脉内膜中层厚度的关系[J].岭南心血管病杂志,2014,20(4):512-515.
[2]陈荣花,张瑞荣,宋巧凤,等.维生素D对原发性高血压患者左室肥厚影响的研究[J].湖南师范大学学报(医学版),2016,13(1):67-69.
[3]左开华.H型高血压患者冠状动脉病变诊断中冠状动脉CT技术应用的价值[J].中国CT和MRI杂志,2016,14(2):60-63.
[4]巫晓芳,吴雅莉.高血压长期服用氢氯噻嗪后RAAS活性与血糖变化的内在关联[J].西部医学,2012,24(2):340-342.
[5]顾朋颖,叶山东,康冬梅,等.甲状腺功能正常的中老年男性高血压患者促甲状腺激素水平与肥胖相关性[J].安徽医科大学学报,2016,51(3):453-456.
[6]刘滨菘,李强,崔璨,等.2型糖尿病合并非酒精性脂肪性肝病患者促甲状腺激素水平变化及其相关性分析[J].临床误诊误治,2016,29(7):91-94.
[7]戴芳,王丽,鞠海兵,等.垂体腺瘤继发库欣病病理分析[J].解放军医药杂志,2012,24(8):23-26.
[8]中国高血压防治指南修订委员会.中国高血压防治指南2010[J].中国医学前沿杂志电子版,2011,39(5):701-708.
[9]刘英,罗兴林.高血压急症患者AngⅡ与IL-6、IgG和补体C3的相关性研究[J].四川医学,2014,35(11):1405-1407.
[10]Kato H,Hou J,Chobanian AV,et al.Effects of angiotensin II infusion and inhibition of nitric oxide synthase on the rat aorta.[J].Hypertension,1996,28(28):153-158.
[11]龙旭东,徐敏.老年原发性高血压患者动态血压参数与部分体液因素的相关性研究[J].实用心脑肺血管病杂志,2011,19(1):1-2.
[12]褚强强,唐海沁,夏光云,等.社区老年高血压患者相关心血管危险因素和不良生活方式状况调查及干预[J].中国临床保健杂志,2014,17(2):134-136.
[13]吴泽刚,熊格,李艳.武汉地区原发性高血压患者高血压四项检测结果分析[J].微循环学杂志,2016,26(1):18-20.
[14]杨悦.联合检测血浆血管紧张素Ⅱ、醛固酮、肾素、血浆凝集素样氧化低密度脂蛋白受体-1、内皮素-1水平对原发性高血压的临床意义[J].中国卫生检验杂志,2016,26(15):2201-2203.
[15]闫杰,刁增利,苏鹏宇,等.原发性高血压患者血浆LOX-1和血管紧张素-Ⅱ、醛固酮的水平变化及相关性[J].中国煤炭工业医学杂志,2014,17(7):1045-1047.
[16]修双玲,王立.异位促肾上腺皮质激素综合征7例临床分析[J].山西医科大学学报,2014,45(9):842-844.
[17]李朝金,张丽.高血压五联检在高血压患者中的应用价值研究[J].医学与社会,2015,28(B05):70-70.
[18]王静,郭金昊,季倩倩,等.中老年原发性高血压病人血压晨峰现象分析[J].中西医结合心脑血管病杂志,2016,14(13):1508-1509.
[19]黄雨晴,冯颖青,陈纪言,等.中老年原发性高血压患者脉压指数与颈动脉内膜中层厚度的关系[J].岭南心血管病杂志,2014,20(4):512-515.