摘要
脓毒症是由于感染引起的免疫功能失调,最终导致的多脏器功能障碍综合征。巨噬细胞作为先天性免疫和适应性免疫的重要组成成分之一,当微环境变化时,可分化成具有不同功能的表型,称为巨噬细胞极化。巨噬细胞极化在脓毒症的免疫调节中发挥重要作用,调控巨噬细胞极化有望成为未来脓毒症治疗的新靶点。因此,本文就巨噬细胞极化及其在脓毒症免疫机制中的作用进行综述。
Sepsis is a syndrome of immune response caused by infection, resulting in multiple organ dysfunction. Macrophages, as one of the important components of innate and adaptive immunity, can differentiate into phenotypes with different functions when the microenvironment changes which is called macrophage polarization. Macrophage polarization plays an important role in the immunoregulation of sepsis.The regulation of macrophage polarization is expected to be one of the new targets for the treatment of sepsis in the future. Therefore, we review the role of macrophage polarization and its underlying mechanisms in the immunoregulation of sepsis.
引文
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